Skin and mucosal fluorescence diagnosis with different light sources

Liutkevičiūtė-Navickienė, Jurgita; Mordas, A.; Rutkovskiene, L.; Bloznelyte-Plesniene, Laima

doi:10.1684/ejd.2008.0612

Cited by 11 publications

(6 citation statements)

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“…Metabolized to fluorescent protoporphyrin-IX, 5-aminolevulinic acid (5-ALA) has been investigated to discriminate cancer using fluorescence. 5-ALA demonstrated pooled 90-95.4% sensitivity and 80-88.6% specificity in KC detection (21,22). However, subclinical extension common to high-risk cutaneous SCC often goes undetected with 5-ALA.…”

Section: Introductionmentioning

confidence: 98%

A Protease-Activated Fluorescent Probe Allows Rapid Visualization of Keratinocyte Carcinoma during Excision

et al. 2020

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Section: Introductionmentioning

confidence: 98%

A Protease-Activated Fluorescent Probe Allows Rapid Visualization of Keratinocyte Carcinoma during Excision

et al. 2020

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“…Recently, remarkable advances have been made in PDD. In human medicine, the clinical use of 5‐ALA for PDD has been reported in numerous areas including dermatology, urology and neurosurgery . PDD is achieved by a photon‐induced physicochemical reaction induced by excitation of PpIX following its exposure to light.…”

Section: Discussionmentioning

confidence: 99%

“…PpIX preferentially accumulates in tumour cells compared with normal tissue and, therefore, 5‐ALA has been widely used in PDD and PDT in human medicine . The use of 5‐ALA in PDD has previously been shown to facilitate visualisation of the bladder, and malignant brain tumours as well as other neoplasms . Furthermore, 5‐ALA PDT has been successfully used in the treatment of a variety of neoplastic and non‐neoplastic diseases .…”

Section: Introductionmentioning

confidence: 99%

Photodynamic detection of canine mammary gland tumours after oral administration of 5‐aminolevulinic acid

Osaki

Yokoe

Ogura

et al. 2016

Vet Comparative Oncology

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5-Aminolevulinic acid (5-ALA) is widely used in photodynamic detection (PDD) and therapy. We evaluated the pharmacokinetics of 5-ALA-induced porphyrins and its effectiveness in PDD in dogs with mammary gland tumours (MGTs) following oral administration. Healthy dogs and those with MGTs (nine each) were orally administered 4 mg kg 5-ALA. Protoporphyrin IX (PpIX) was not detected in the plasma of healthy dogs but it peaked in dogs with MGT at 2 h after 5-ALA administration. In the PDD study, 16 dogs with MGT were orally administered 40 mg kg 5-ALA, and MGT but not normal tissue showed red fluorescence after 2-4 h. Photon counts were 6635-63 890 and 59-4011 (median, 19 943 and 919) for MGT and non-tumour tissues, respectively. Cell density strongly correlated with PpIX photon counts of MGT tissue of the dogs (R = 0.743, P = 0.0009). We suggest that 5-ALA-PDD might be an effective diagnostic tool for MGTs.

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“…A blue‐near‐UV‐light source (370–405 nm), that is, Wood's lamp activates the red fluorescence of the (pre)malignant area. Even though we admit that fluorescence diagnosis using Woods light is outdated, it has shown high accuracy in detection of skin (pre)malignancies .…”

Section: Introductionmentioning

confidence: 99%