Skin and soft tissue infections

Leong, Clare; Gouliouris, Theodore

doi:10.1016/j.mpmed.2021.08.007

Cited by 5 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Good in vivo Gram-selective antibacterial properties have been demonstrated by treating wound mouse models with these AMP hydrogels; the results suggest that the hydrogels promote wound healing. We believe that these Gram-selective AMP hydrogels could have potentially important applications in treating common recurring infections such as urinary tract infections, [62][63][64] abscesses, [65][66][67] or skin and soft tissue infections, [68][69][70] as well as other non-lifethreatening infections.…”

Section: Introductionmentioning

confidence: 99%

Gram-selective antibacterial peptide hydrogels

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Gram-selective antibacterial peptide hydrogels

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It plays an immunological role, as it acts as a mechanical, physical and chemical barrier, protecting internal structures against infections and injuries of different nature, such as cuts, traumas, burns and ulcers [ 57 ]. In addition to functioning as an “envelope” for the body, the skin regulates moisture loss and changes in body temperature while also acting as natural mechanism to promote the reconstitution of its structure when damaged, which makes up the wound healing cascade [ 6 , 58 ].…”

Section: Soft Tissues Engineeringmentioning

confidence: 99%

“…An intrinsic characteristic of soft and hard tissues is the ability to induce regeneration mechanisms [ 5 , 6 ]. In bone, osteoblastic cells initiate the process from the secretion of collagen and, subsequently, the crystallization of hydroxyapatite [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Barreto

Medeiros

Shearer

et al. 2022

JFB

View full text Add to dashboard Cite

Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on biopolymers and BG particles have been developed with various state-of-the-art techniques for tissue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydrogels, fibers, films, and scaffolds. Searching “bioactive glass gelatin” in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, including the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic responses in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined.

show abstract

“…It plays an immunological role, as it acts as a mechanical, physical and chemical barrier, protecting internal structures against infections and injuries of different nature, such as cuts, traumas, burns and ulcers [51]. In addition to functioning as an "envelope" for the body, the skin regulates moisture loss and changes in body temperature while also acting as natural mechanism to promote the reconstitution of its structure when damaged, which makes up the wound healing cascade [6,52].…”

Section: Soft Tissues Engineeringmentioning

confidence: 99%

“…An intrinsic characteristic of soft and hard tissues is the ability to induce, on their own, regeneration mechanisms [5,6]. In bone, osteoblastic cells initiate the process from the secretion of collagen and, subsequently the crystallization of hydroxyapatite [7].…”

Section: Introductionmentioning

confidence: 99%

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Barreto¹,

Medeiros²,

Shearer³

et al. 2022

Preprint

View full text Add to dashboard Cite

Nano/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique an-ti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on bi-opolymers and BG particles have been developed with various state-of-the-art techniques for tis-sue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydro-gels, fibers, films, scaffolds, etc. Searching "bioactive glass gelatin" in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, in-cluding the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic respons-es in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined.

show abstract

Skin and soft tissue infections

Cited by 5 publications

References 5 publications

Gram-selective antibacterial peptide hydrogels

Gram-selective antibacterial peptide hydrogels

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Contact Info

Product

Resources

About