Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

Capasso, Anna; Bilancio, Giancarlo; Lee, Michael W.; Palladino, Giuseppe; Pollastro, Rosa Maria; Simeoni, Mariadelina; Secondulfo, Carmine; Ronchi, Andrea; Caputo, Alessandro; Franco, Renato; Zeppa, Pio; Capasso, Giovambattista; Viggiano, Davide

doi:10.21873/anticanres.14396

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…However, patients with locally advanced or metastatic disease have worse prognoses. Considerable research has been performed in recent years to better understand the pathophysiology of cSCC and improve treatment (12)(13)(14). Unresectable lesions are generally treated with curative radiotherapy alone, which includes high total and biologically effective doses and generally takes several weeks.…”

Section: Discussionmentioning

confidence: 99%

Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region

Staackmann

Schild

Rades

2021

In Vivo

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Background/Aim: Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer. Options for palliative treatment include systemic agents and radiotherapy. Selection of a radiation regimen should consider the patient's survival prognosis. This study aimed to identify prognostic factors of survival after palliative radiotherapy for cSCC of the head-and-neck. Patients and Methods: Ten factors were analyzed for survival in 12 patients including age, gender, tumor site, histological grade, primary tumor stage, lymph node involvement, distant metastases, upfront surgery, radiation dose and completion of radiotherapy. Results: On univariate analysis, improved survival was significantly associated with lower histological grade (better differentiation) (p=0.022), no distant metastases (p=0.040) and completion of radiotherapy (p=0.014). In the multivariate analysis, lower histological grade (risk ratio=6.05, p=0.100) and completion of radiotherapy (risk ratio=4.87, p=0.115) showed trends. Conclusion: Predictors of survival were identified that can help design individual treatments. Patients require optimal supportive care as completion of radiotherapy was associated with better survival.

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Section: Discussionmentioning

confidence: 99%

Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region

Staackmann

Schild

Rades

2021

In Vivo

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“…35 However, when examining the intact skin close to the BCC or SCC site, a more intense inflammatory reaction can be observed. 36,37 Conversely, the peritumoral inflammatory infiltrate was increased in BCC and decreased in SCC in KT patients compared to their non-transplanted controls. 36…”

Section: Inflammation In Non-melanoma Skin Cancer Of Kt Patientsmentioning

confidence: 94%

“…36,37 Conversely, the peritumoral inflammatory infiltrate was increased in BCC and decreased in SCC in KT patients compared to their non-transplanted controls. 36…”

Section: Inflammation In Non-melanoma Skin Cancer Of Kt Patientsmentioning

confidence: 94%

“…44 The additional observation that topical use of calcineurin inhibitors does not change the risk of non-melanoma skin cancer 38 further confirm that CNI increases the risk of non-melanoma skin cancer through a direct effect on the skin (which is not present in HIV patients) but a complementary permissive tumoral inflammatory microenvironment must be present. 36 The additional role of chronic kidney disease should also be taken into consideration, although the correct evaluation of kidney function in these patients may be tricky. 45 Thus, when taken together, further study is needed to validate our hypothesis and determine the precise mechanism underlying the putative interaction between immunosuppressants and epidermal cells that could lead to malignant transformation.…”

Section: The Relationship Between Immunosuppression and The Developmementioning

confidence: 99%

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A new hypothesis to explain skin cancer risk in kidney allograft recipients

Viggiano

Lee

Simeoni

et al. 2020

Journal of Onco-Nephrology

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Kidney transplant (KT) recipients have an increased risk for specific types of cancer. Some forms of incident cancer are similarly present in other diseases where T-cells are depleted, such as HIV-infection: specifically, non-Hodgkin lymphoma and Kaposi’s sarcoma. Conversely, other forms of highly incident cancers in KT patients, primarily non-melanoma skin cancer (squamous cell carcinoma and basal cell carcinoma), are specific to this condition. By comparing HIV-related cancers, general cancer incidence, and the association of immunotherapy with cancer incidence, we suggest that the high incidence of non-melanoma skin cancer seen in KT patients is mediated by off-target effects of calcineurin inhibitors in the skin, combined with a “permissive” cancer microinflammatory environment.

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Gut mucosa alterations after kidney transplantation: a cross sectional study

Joshi,

Secondulfo,

Caputo

et al. 2024

J Nephrol

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Background Kidney transplant recipients (KTRs) rely on immunosuppressants like mycophenolate to prevent organ rejection. However, mycophenolate often causes intestinal symptoms and inflammation in various organs, including the skin and the colon. While KTRs have an increased risk for skin cancer, the risk of colorectal cancer is not increased. Elucidating the histological alterations in the colon of KTRs and comparing these changes with known skin alterations would help understand how immunosuppressants influence cancer development and progression. Methods Whole slide images from gut biopsies (Non-transplanted subjects n = 35, KTRs n = 49) were analyzed using the ImageJ and R programming environment. A total of 22,035 epithelial cells, 38,870 interstitial cells, 3465 epithelial cell mitoses, and 7477 endothelial cells, each characterized by multiple microscopy parameters, from a total of 1788 glands were analyzed. The large database was subsequently analyzed to verify the changes of inflammatory milieu in KTRs and in cancer. Results KTRs without colon-cancer showed a significantly higher density of interstitial cells in the colon compared to non-transplanted patients. Moreover, the increase in interstitial cell number was accompanied by subtle modifications in the architecture of the colon glands, without altering the epithelial cell density. We could not identify significant structural modifications in cancer samples between KTRs and non-transplanted patients. Conclusions Our findings demonstrate an increased number of resident interstitial cells in the colon of KTRs, as in other patients treated with mycophenolate. These changes are associated with subtle alterations in the architecture of colon glands. Graphical abstract

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Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

Cited by 3 publications

References 23 publications

Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region

Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region

A new hypothesis to explain skin cancer risk in kidney allograft recipients

Gut mucosa alterations after kidney transplantation: a cross sectional study

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