Skin autofluorescence is elevated in acute myocardial infarction and is associated with the one-year incidence of major adverse cardiac events

Abstract

BACKGROUND.: ST-elevation myocardial infarction (STEMI) is associated with increased inflammation and oxidative stress, enhancing the formation of advanced glycation endproducts (AGEs). These encompass a characteristic fluorescence pattern, which can be non-invasively measured as skin autofluorescence (AF). In this study we investigate whether skin AF is elevated in STEMI, its association with inflammatory and glycaemic stress and its predictive value for future events. METHODS.: Skin AF was measured in 88 STEMI patients (mean age 64+/-13 years) within 72 hours and around six months after discharge, in 81 stable coronary artery disease (sCAD) patients (64+/-10 years), and in 32 healthy controls (63+/-11 years). The cumulative one-year incidence of all-cause mortality and hospitalisation for myocardial infarction or heart failure was documented. RESULTS.: Skin AF was significantly higher in STEMI compared with sCAD and controls, irrespective of confounders, and was associated with HbA1c and C-reactive protein. Skin AF decreased significantly in STEMI patients, when measured >200 days after discharge. In STEMI patients, skin AF above the median was predictive of future events (hazard ratio 11.6, 95% CI 1.5 to 90.8, p=0.019). CONCLUSION.: Skin AF is elevated in STEMI, is associated with inflammation and glycaemic stress, and predicts future major adverse cardiac events. (Neth Heart J 2009;17:162-8.Neth Heart J 2009;17:162-8.).

Skin Autofluorescence–Indicated Advanced Glycation End Products as Predictors of Cardiovascular and All‐Cause Mortality in High‐Risk Subjects: A Systematic Review and Meta‐analysis

“…SAF‐indicated AGE levels are elevated in diabetes mellitus and end stage renal disease, and some studies suggest that they are associated with CVD independent of known CVD risk factors 13, 14, 15. In fact, recent reviews have pointed out a role for SAF levels as new biomarkers of CVD and diabetes mellitus complications 16, 17…”

Skin Autofluorescence Is Associated With 5-Year Mortality and Cardiovascular Events in Patients With Peripheral Artery Disease

“…8,13,14 Recently, we have shown that SAF is increased in patients with PAD independent of conventional cardiovascular risk factors and cardiovascular morbidity. 10 The aim of the present study was to establish whether SAF, as a measure of tissue AGEs deposition, is associated with all-cause mortality and with fatal or nonfatal major adverse cardiovascular events (MACE) in patients with PAD.…”

Mathematical model of power characteristics of the diagnostic fluorimeter

“…Excitation of fluorescence of AGE which are contained in skin -a research object 5, is carried out by the radiation of a short-range ultra-violet or violet LED or the junction laser 1 which passes through the collimating optics 2 and the clearing light filter 3. The range of radiation of excitation of AFR of 350 -415 nanometers is caused by the AGE fluorescent properties [1][2]17], and in the specified range noticeable spectral non-uniformity efficiency of AFR excitation isn't marked that causes a designer level of freedom in a radiator choice. Fig.…”

“…[8], by means of which researches [1][2][3] are conducted. The instruments AGE Reader have the sizes of the netbook and are easy-to-work.…”

“…Fluorescence of AGE is excited by the mercury lamp, and is elastic dispersed by skin and fluorescent the radiations reaching an input end face of receiving optical fiber are transferred to them to a compact spectrometer. Diagnostic parameter in the instruments AGE Reader the integral criterion of the AFR [1,2] …”