Skin barrier damaging and repairing process: A new application field of dermoscopy

Ye, Congxiu; Yi, Jing; Wei, Lai; Zheng, Yue

doi:10.1111/jocd.13643

Cited by 5 publications

(7 citation statements)

References 39 publications

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“…Optical coherence tomography (OCT) shows uneven epidermal surface, significant light attenuation, and reduced papillary layer in the dermis (collagen degeneration) during aging (Mamalis et al, 2015). Dermatoscopic features of skin aging include severe xerosis, surface irregularity, atrophy, uneven pigmentation, telangiectasia, miniaturized HFs, and hair graying (Hu et al, 2019a;Ye et al, 2021). As observed by high-frequency ultrasound imaging, the echogenicity of the aged skin is diminished and its thickness decreases; besides, the aged dermis shows more irregularities in the subdermal interface (Vergilio et al, 2021).…”

Section: Imaging Traitsmentioning

confidence: 99%

Biomarkers of aging

Bao

Cao

Chen

et al. 2023

Sci. China Life Sci.

153

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Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant. Supporting Information The supporting information is available online at 10.1007/s11427-023-2305-0. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Section: Imaging Traitsmentioning

confidence: 99%

Biomarkers of aging

Bao

Cao

Chen

et al. 2023

Sci. China Life Sci.

153

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“…Moreover, cleaning hands with soap and water removes skin lipids as they are rinsed off, whereas they remain on the skin when using ABHS 30 . Lipids may be also potentially wiped off when using disinfectant wipes, 32 explaining their higher epidermal disruption compared with ABHS. Furthermore, the type of hand hygiene product was found to be an independent predictor for change in TEWL after adjusting for other variables, namely, gender and age, whose influence on TEWL is controversial 32 .…”

Section: Discussionmentioning

confidence: 99%

“…Lipids may be also potentially wiped off when using disinfectant wipes, 32 explaining their higher epidermal disruption compared with ABHS. Furthermore, the type of hand hygiene product was found to be an independent predictor for change in TEWL after adjusting for other variables, namely, gender and age, whose influence on TEWL is controversial 32 . Other factors, including the number of hand hygiene procedures and skin temperatures, which may have an impact on TEWL, 13 were similar in the three groups.…”

Section: Discussionmentioning

confidence: 99%

Assessment of hand hygiene strategies on skin barrier function during COVID‐19 pandemic: A randomized clinical trial

et al. 2022

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Introduction Coronavirus disease 2019 (COVID‐19) has increased the frequency of handwashing. There is scarce evidence regarding the impact of different hand hygiene procedures on skin barrier function in clinical practice. Objective To compare the impact on skin barrier function of different hand hygiene measures in healthcare workers in daily practice. Methods A randomized controlled clinical trial was conducted. Participants were randomized to sanitize their hands with water and soap, alcohol‐based hand sanitizers (ABHSs), or disinfectant wipes during their 8‐hour working shift. Epidermal barrier functional parameters, such as transepidermal water loss (TEWL), and the microbial load were assessed before and immediately after the working day. Tolerance and acceptability of each product were recorded after work. Results Sixty‐two participants were included and 20, 21, and 21 were randomized to use water and soap, ABHS, and disinfectant wipes, respectively. After the 8‐hour shift, TEWL increase was higher with disinfectant wipes than with soaps or ABHS (+5.45 vs +3.87 vs −1.46 g h−1 m−2, respectively; P = .023). Bacteria and fungi colony‐forming unit (CFU) count reductions were lower for the water and soap group than for ABHS and disinfectant wipes. Disinfectant wipes were considered more difficult to use (P = .013) compared with water and soap and ABHS. Conclusion Daily hand hygiene with ABHS showed the lowest rates of skin barrier disruption and the highest reduction of CFU.

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“…At each visit, all volunteers were asked to prepare their face following the procedures described in the previous report 13 …”

Section: Methodsmentioning

confidence: 99%

A new product of multi‐plant extracts improved skin photoaging: An oral intake in vivo study

Xie

Zhu

et al. 2021

J of Cosmetic Dermatology

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Background Besides the topical application of cosmetics, nutraceuticals represent a promising strategy for preventing skin photoaging and skin cancers. Methods To determine the effect of a new multi‐plant extracts product containing Cucumis melo extract, acerola extract, olive fruit, aloe vera gel, grape seed extract, and lycopene, a randomized, placebo‐controlled, double‐blind clinical trial and an ultraviolet (UV)‐induced murine photoaging model were deployed. 55 healthy subjects aged 45–60 were enrolled and randomized to take the product or placebo orally for 12 weeks. Skin aging and whitening indexes were measured with non‐invasive techniques. 90 Balb/c mice aged 7–8 weeks were randomly divided into six groups: normal, UV, UV+vehicle, UV+different doses of the product (0.500 g/kg.BW, 0.250 g/kg.BW, 0.125 g/kg.BW, respectively). Except the normal group, mid‐dorsal regions were irradiated with UVA+UVB for 8 weeks. Factors of oxidative stress, tyrosinase, and histological analysis of the mid‐dorsal skin were determined. Results In the clinical trial, the TEWL, hydration, sebum, elasticity, and the L*, a*, melanin index change from baseline, ITA° were significantly improved in the experiment group. In the animal experiment, compared to the UV+vehicle group, UV+high dose group showed significantly lower malondialdehyde (MDA) and tyrosinase, but higher superoxide dismutase (SOD), total antioxidant capacity (T‐AOC), and glutathione peroxidase (GSH‐Px). The UV+moderate dose group showed significant improvement of MDA and GSH‐Px, and the UV+low dose group only showed improvement of GSH‐Px. Histological photoaging manifestations were attenuated in the UV+high and moderate dose groups. Conclusions The multi‐plant extracts product improved skin photoaging possibly via antioxidant and anti‐tyrosinase ways.

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Skin barrier damaging and repairing process: A new application field of dermoscopy

Cited by 5 publications

References 39 publications

Biomarkers of aging

Biomarkers of aging

Assessment of hand hygiene strategies on skin barrier function during COVID‐19 pandemic: A randomized clinical trial

A new product of multi‐plant extracts improved skin photoaging: An oral intake in vivo study

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