Skin Barrier Defects in Atopic Dermatitis

Agrawal, Rachana; Woodfolk, Judith A.

doi:10.1007/s11882-014-0433-9

Cited by 174 publications

(131 citation statements)

References 116 publications

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“…As a result, the whole process of terminal differentiation of the keratinocytes (cytoplasmic compaction, cornification and the release of lipids) necessary for the establishment of the barrier function is defective [37]. Furthermore, the reduction in the antimicrobial activity makes the patient susceptible to skin infections, sensitivity to allergens and a state of constant inflammation [38].…”

Section: Discussionmentioning

confidence: 99%

Bacterial Derivatives of Lactococcus lactis and Ectoin for Atopic Dermatitis: Dermal Compatibility and Cosmetic Acceptability

Crespo¹

2017

PPIJ

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Section: Discussionmentioning

confidence: 99%

Bacterial Derivatives of Lactococcus lactis and Ectoin for Atopic Dermatitis: Dermal Compatibility and Cosmetic Acceptability

Crespo¹

2017

PPIJ

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“…The epidermal barrier plays a key role in immune surveillance and homeostasis, in preventing the penetration of the products of microorganisms and allergens [21].…”

Section: Discussionmentioning

confidence: 99%

The frequency of polymorphic variants of filaggrin gene and clinical atopic dermatitis

Filipowska-Grońska

Weryńska-Kalemba

Bożek

et al. 2016

pdia

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A b s t r a c tIntroduction: As far as pathogenesis of the atopic dermatitis (AD) is concerned, the roles of an impaired epidermal barrier and cornified cell envelope are widely emphasized. Aim: The assessment of mutations of the filaggrin gene and their connection with the clinical picture of AD as well as selected allergological and environmental indicators. Material and methods: 105 patients with diagnosed AD on the basis of diagnostic criteria were included. For every patient of the examined group, quantitative determination of the total concentration of IgE and the concentration of IgE antibodies to selected allergens were examined. For all patients, studies were performed by means of analysis of two genomic gene variants of profilaggrin (FLG) -R501X and 2282del4. Results: Loss-of-function mutations in the filaggrin gene were shown in 12 (11.4%) patients in the examined group. All patients in the study group who developed one of the tested loss-of-function mutations in the filaggrin gene demonstrated an extrinsic, allergic form of atopic dermatitis. A significant association (p = 0.0002) between the presence of one of the tested loss-of-function mutations in the filaggrin gene and elevated levels of total concentration of immunoglobulin E was shown. Conclusions: Patients with AD of null mutations in the filaggrin gene demonstrate a relationship with the total and specific concentration of immunoglobulin E, specifically higher concentrations of IgE against aeroallergens and alimentary allergens as well as elevated levels of total immunoglobulin E.

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“…Interestingly, the few studies evaluating the effect of antihistamines, including H4 blockers, have failed to report a beneficial effect [28,29]. In a subset of human patients with AD, genetically inherited skin barrier defects are demonstrable and further skin barrier impairment occurs once sensitization develops and inflammation is triggered [30]. Thus, skin barrier impairment can be both primary and secondary and it plays some role in all patients at some point during the course of the disease.…”

Section: Atopic Dermatitis: Comparative Observationsmentioning

confidence: 99%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

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Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

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Skin Barrier Defects in Atopic Dermatitis

Cited by 174 publications

References 116 publications

Bacterial Derivatives of Lactococcus lactis and Ectoin for Atopic Dermatitis: Dermal Compatibility and Cosmetic Acceptability

Bacterial Derivatives of Lactococcus lactis and Ectoin for Atopic Dermatitis: Dermal Compatibility and Cosmetic Acceptability

The frequency of polymorphic variants of filaggrin gene and clinical atopic dermatitis

Animal Models of Allergic Diseases

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