Skin Barrier in Atopic Dermatitis

Schmuth, Matthias; Eckmann, Sonja; Moosbrugger-Martinz, Verena; Ortner-Tobider, Daniela; Blunder, Stefan; Trafoier, Thomas; Gruber, Robert; Elias, Peter M.

doi:10.1016/j.jid.2024.03.006

Journal of Investigative Dermatology

2024

DOI: 10.1016/j.jid.2024.03.006

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Skin Barrier in Atopic Dermatitis

Matthias Schmuth,

Sonja Eckmann,

Verena Moosbrugger-Martinz

et al.

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Cited by 6 publications

References 189 publications

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Atopic dermatitis: pathogenesis and therapeutic intervention

Yue,

Zhou,

Wang

et al. 2024

MedComm

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The skin serves as the first protective barrier for nonspecific immunity and encompasses a vast network of skin‐associated immune cells. Atopic dermatitis (AD) is a prevalent inflammatory skin disease that affects individuals of all ages and races, with a complex pathogenesis intricately linked to genetic, environmental factors, skin barrier dysfunction as well as immune dysfunction. Individuals diagnosed with AD frequently exhibit genetic predispositions, characterized by mutations that impact the structural integrity of the skin barrier. This barrier dysfunction leads to the release of alarmins, activating the type 2 immune pathway and recruiting various immune cells to the skin, where they coordinate cutaneous immune responses. In this review, we summarize experimental models of AD and provide an overview of its pathogenesis and the therapeutic interventions. We focus on elucidating the intricate interplay between the immune system of the skin and the complex regulatory mechanisms, as well as commonly used treatments for AD, aiming to systematically understand the cellular and molecular crosstalk in AD‐affected skin. Our overarching objective is to provide novel insights and inform potential clinical interventions to reduce the incidence and impact of AD.

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Atopic dermatitis: pathogenesis and therapeutic intervention

Yue,

Zhou,

Wang

et al. 2024

MedComm

View full text Add to dashboard Cite

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From stimuli-responsive polymers to nanosystems and electrocircuits: An update on the current state of polymeric hydrogel microneedles for wound healing

Pires,

Renca,

Amaro

et al. 2024

Journal of Drug Delivery Science and Technology

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Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding

Brown,

Gudjonsson

2024

Journal of Investigative Dermatology

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Skin Barrier in Atopic Dermatitis

Cited by 6 publications

References 189 publications

Atopic dermatitis: pathogenesis and therapeutic intervention

Atopic dermatitis: pathogenesis and therapeutic intervention

From stimuli-responsive polymers to nanosystems and electrocircuits: An update on the current state of polymeric hydrogel microneedles for wound healing

Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding

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