Skin Biopsy in Berger’s Disease: Is It Really Useful in the Diagnosis?

Ensari, Cüneyt; Ensarı, Arzu; Aylı, Deniz; Ekı̇m, Mesı̇ha; Yalçınkaya, Fatoş; Tümer, Necmiye

doi:10.1159/000045590

Cited by 2 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The value of cutaneous DIF in the study of renal diseases is controversial, because the presence of IgA deposits in cutaneous vessels of patients with mesangial glomerulonephritis (Berger disease) ranges from 0 to 100%. 20 However, IgA in cutaneous vessels has also been detected in other glomerulonephritis, including immunocomplex-mediated and nonimmunocomplex-mediated glomerulonephropathy, therefore limiting the usefulness of the test as a diagnostic aid. 21 The lack of or low positivity for IgA reported in early studies of LV may justify the still-existing controversy about the adequate interpretation of IgA deposits in classification of cutaneous vasculitis, especially Schönlein-Henoch vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic, prognostic and pathogenic value of the direct immunofluorescence test in cutaneous leukocytoclastic vasculitis

Barnadas¹,

Pérez²,

Gich³

et al. 2003

Int J Dermatology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnostic, prognostic and pathogenic value of the direct immunofluorescence test in cutaneous leukocytoclastic vasculitis

Barnadas¹,

Pérez²,

Gich³

et al. 2003

Int J Dermatology

View full text Add to dashboard Cite

show abstract

“…In other diseases, this approach has been less successful. For examples, dermal IgA staining has been proposed as a diagnostic tool for IgA nephropathy, but studies have failed to confirm its usefulness [24].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of skin immunofluorescence for distinguishing SLE from SLE-like renal lesions: a pilot study

et al. 2010

View full text Add to dashboard Cite

Lupus nephritis (LN) may represent a diagnostic problem, particularly in pediatric patients that present with typical histological lesions but do not fulfill the American Rheumatism Association (ARA) criteria for the diagnosis of systemic lupus erythematosus (SLE). Based on the well-described deposition of immunoglobulins (Ig) and complement at the dermoepithelial junction in SLE, we hypothesized that skin biopsies may help in the diagnosis of LN. To test this hypothesis, we carried out a pilot study, performing a skin biopsy in 22 patients with LN and 13 patients with lupus-like lesions, regardless of the time elapsed from onset of renal disease. The latter group of patients was further divided into a purely renal group, designated as isolated full-house nephropathy (FHN), and a dubious cases group, presenting with additional clinical and biological features consistent with SLE but insufficient for diagnosing SLE. None of the 6 isolated FHN patients had positive skin immunofluorescence. Conversely, 5/7 patients in the dubious cases group (p<0.02) and 13/22 in the LN group (p<0.002) had positive staining for C1q, and 5/7 patients in the dubious cases group (p<0.02) and 16/22 patients in the LN group (p<0.001) had positive staining for IgM. No correlation was observed with the time elapsed from the initial diagnosis. These data suggest that skin biopsies may help distinguishing LN from isolated FHN. In addition, they identify an intermediate group of patients with evidence of systemic involvement despite the absence of a sufficient number of ARA criteria to be labeled as SLE.

show abstract

Skin Biopsy in Berger’s Disease: Is It Really Useful in the Diagnosis?

Cited by 2 publications

References 9 publications

Diagnostic, prognostic and pathogenic value of the direct immunofluorescence test in cutaneous leukocytoclastic vasculitis

Diagnostic, prognostic and pathogenic value of the direct immunofluorescence test in cutaneous leukocytoclastic vasculitis

Usefulness of skin immunofluorescence for distinguishing SLE from SLE-like renal lesions: a pilot study

Contact Info

Product

Resources

About