Skin Biosensing and Bioanalysis: what the Future Holds

Ng, Keng Wooi; Moghimi, S. Moein

doi:10.33218/prnano1(2).180709.1

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…This practice paves the way for using microneedle diagnostic technologies to detect a host of other infectious diseases with known circulating-free DNA targets, including malaria and tuberculosis [33], [34]. Recent advances in other areas closely related to skin bi-osensing and bioanalysis, such as nanotechnology and 3D printing, will likely further enhance microneedle-based diagnostics [35].…”

Section: Microneedle Diagnostic Platformsmentioning

confidence: 97%

The diagnostic potential of microneedles in infectious diseases

Dixon

Lau

Moghimi

et al. 2020

Precision Nanomedicine

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The coronavirus disease 2019 (COVID-19) pandemic has taught us much about our weaknesses in the management of infectious disease outbreaks. A key lesson has been the need for more effective pointof-care diagnostic tools that produce not only rapid and reliable results but also facilitate decentralised testing to avoid overwhelming central test facilities when demand peaks in an outbreak. Microneedle devices can be inserted painlessly into the skin to detect biomolecules in the epidermal and dermal layers. They have been used to identify biomarkers in both the interstitial fluid and capillary blood. Importantly, they are amenable to self-administration. In this article, we provide an overview of existing microneedle-based diagnostic technologies and discuss how they may be built upon to provide effective diagnostic tools for infectious diseases.

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Section: Microneedle Diagnostic Platformsmentioning

confidence: 97%

The diagnostic potential of microneedles in infectious diseases

Dixon

Lau

Moghimi

et al. 2020

Precision Nanomedicine

Self Cite

View full text Add to dashboard Cite

show abstract

Microneedle-based devices for point-of-care infectious disease diagnostics

Dixon

Skaria

Lau

et al. 2021

Acta Pharmaceutica Sinica B

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Recent infectious disease outbreaks, such as COVID-19 and Ebola, have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission. Successful diagnostic strategies critically depend on the efficiency of biological sampling and timely analysis. However, current diagnostic techniques are invasive/intrusive and present a severe bottleneck by requiring specialist equipment and trained personnel. Moreover, centralised test facilities are poorly accessible and the requirement to travel may increase disease transmission. Self-administrable, point-of-care (PoC) microneedle diagnostic devices could provide a viable solution to these problems. These miniature needle arrays can detect biomarkers in/from the skin in a minimally invasive manner to provide (near-) real-time diagnosis. Few microneedle devices have been developed specifically for infectious disease diagnosis, though similar technologies are well established in other fields and generally adaptable for infectious disease diagnosis. These include microneedles for biofluid extraction, microneedle sensors and analyte-capturing microneedles, or combinations thereof. Analyte sampling/detection from both blood and dermal interstitial fluid is possible. These technologies are in their early stages of development for infectious disease diagnostics, and there is a vast scope for further development. In this review, we discuss the utility and future outlook of these microneedle technologies in infectious disease diagnosis.

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Precision Nanomedicine Volume 1 Issue 2 Table of Contents

2018

PRNANO

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Skin Biosensing and Bioanalysis: what the Future Holds

Cited by 3 publications

References 31 publications

The diagnostic potential of microneedles in infectious diseases

The diagnostic potential of microneedles in infectious diseases

Microneedle-based devices for point-of-care infectious disease diagnostics

Precision Nanomedicine Volume 1 Issue 2 Table of Contents

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