Objective. This study intends to analyze the difference in the efficacy of drainage skin-bridge sparing surgery combined fistulotomy (DSCF) and fistulotomy alone. Methods. 125 patients with anal fistula were enrolled as study subjects and randomly divided into control group (CG) and observation group (OG) by double-blind lottery. The CG received drainage skin-bridge sparing surgery with fistulotomy and the OG received fistulotomy only. Results. The VAS scores of the trauma in the OG were lower than those in the CG on 1st day of surgery and 7 days after surgery (
P
<
0.05
). The length of hospital stay and time to wound healing were shorter in the OG than in the CG (
P
<
0.05
). The incidence of postoperative bleeding in the OG was 9.52%, which was lower than 22.58% in the CG (
P
<
0.05
). The rectal examination scores were lower in the OG than in the CG at 3 and 5 days postoperatively (
P
<
0.05
). The Wexner scores of solid incontinence (0 to 4), liquid incontinence (0 to 4), gas incontinence (0 to 4), pad wearing (0 to 4), and lifestyle alteration (0 to 4) in the OG were lower than those of the CG at 5 days postoperatively (
P
<
0.05
). Voiding function scores were lower in the OG than in the CG at 2 and 3 days postoperatively (
P
<
0.05
). Conclusions. The efficacy of drainage skin-bridge sparing surgery combined fistulotomy is better than that of fistulotomy alone, which can accelerate postoperative healing, enhance urinary function, reduce postoperative bleeding, and improve anal function.