Skin cancer and papillomaviruses in cattle

Spradbrow, P. B.; Samuel, J.L.; Kelly, W. R.; Wood, Anne

doi:10.1016/0021-9975(87)90025-9

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…At least 6 different types of bovine papillomavirus (BPV) have been identified; BPV1; BPV2 and BPV5 cause cutaneous fibropapilloma, while BPV3, 4, 6 cause squamous papillomas of the skin and esophagus (Yager et al, 1993 andGoldshmidt &Hendrick, 2002). Spradbrow et al, (1987) suggested that cutaneous tumours may be the outcome of a complex series of interactions of the epidermal and adenexal cells with papillomavirus, ultraviolet rays and other factors such as immunosuppressive or photosensitizing agents. Solar radiation is predisposing factor in SCC in the ears and nose of white cats, on the perineum and ears of Angora goats in Africa and on the eyelids of cattle.…”

Section: Introductionmentioning

confidence: 99%

A survey of tumors affecting cattle, buffaloes and sheep, in El-Dakahlyia Governorate

Moharram

Awadin²,

hamed

et al. 2019

Mansoura Veterinary Medical Journal

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In a 2-year survey of tumors occurring in ruminants reared in El-Dakahlyia Governorate, Egypt during the period from October 2016 to October 2018. 66 tumor masses were collected: 60 from cattle, 2 from buffaloes and 4 from sheep. According to histopathology of cattle tumors, 15 neoplasms were diagnosed as cutaneous papilloma, 5 neoplasms were diagnosed as cutaneous fibropapillomas, 25 neoplasms were diagnosed as squamous-cell carcinoma (SCC) of the eye; 8 neoplasms were diagnosed as SCC of perineum, 1 neoplasm was diagnosed as SCC in skin of muzzle, 2 neoplasms were diagnosed as epulis in dental pad, 2 neoplasms were diagnosed as vaginal leiomyoma, 1 neoplasm was diagnosed as fibroma and 1 neoplasm was diagnosed as liposarcoma. Histopathology of buffalo tumors revealed SCC in head skin (1 case) and buccal cavity (1 case). Histopathology of sheep tumors revealed SCC in skin under the tail (2 cases), skin of groin (1 case) and skin of abdomen (1 case). In conclusion, cattle (60/66) were more susceptible to tumors than buffaloes (2/66) and sheep (4/66). Females accounted for a higher percentage of the neoplasms (47/66) than males (19/66). Adult animals aged above 2 years were more frequently affected than young. The occurrence of epithelial tumors (60/66) was greater than the mesenchymal tumors (6/66). The most common epithelial tumors were ocular SCC and cutaneous papilloma. Number of malignant tumors (41/66) was higher than number of benign tumors (25/66). Variable degrees of bovine SCC differentiation were detected. Meanwhile ovine SCC appeared only well differentiated.

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Section: Introductionmentioning

confidence: 99%

A survey of tumors affecting cattle, buffaloes and sheep, in El-Dakahlyia Governorate

Moharram

Awadin²,

hamed

et al. 2019

Mansoura Veterinary Medical Journal

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“…10 However, the variable presence of papillomavirus DNA in penile SCC may suggest that the precursor lesions (papillomas) are initiated by the virus, but subsequent promotion and progression to malignancy is not directly associated with the virus. 16 Future studies will investigate the presence of EcPV-2 in non-SCC penile diseases.…”

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confidence: 99%

Detection of papillomavirus in equine periocular and penile squamous cell carcinoma

et al. 2013

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Squamous cell carcinoma (SCC) is the most common tumor arising in the periocular and penile areas of horses. Both ultraviolet radiation and papillomaviruses have been implicated in the pathogenesis of SCC in various species, including the horse. This retrospective study used polymerase chain reaction (PCR) to detect papillomavirus DNA in archival biopsy samples from equine periocular and penile SCC from 3 different geographic areas (northeast, southeast, and central United States). Forty-two periocular SCCs were tested; none contained papillomavirus DNA. Twenty-two penile SCCs were tested, and papillomavirus DNA was identified in 10 (43%) cases. Sequencing of the PCR products revealed homology with Equus caballus papillomavirus 2 (EcPV-2). No geographic distribution in the detection of papillomavirus was identified. Penile SCCs were significantly more likely to be papillomavirus positive than the periocular SCCs ( P < 0.001). The role of papillomavirus in the development of penile SCC requires further investigation. The differing pathogeneses of periocular and penile SCC suggest that the tumors may respond differently to treatment.

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“…4,18 These¯ndings suggest a possibility of di®erent pathogeneses in the development of equine penile papilloma and PSCC, wherein EcPV2 may serve as the initiator, but subsequent tumor promotion and progression to malignancy can vary and are not necessarily associated with EcPV2. 4,19 It is also likely that EcPV2 may be eliminated by the host responses before the development of cancerous lesions and thus be undetected intralesionally.…”

Section: Discussionmentioning

confidence: 99%

A Penile Squamous Cell Carcinoma With Systemic Metastasis in a Thoroughbred Horse

Chen

Jeng

et al. 2017

Taiwan Vet J

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A 22-year-old gelding Thoroughbred horse had been in poor physical condition with a prolapsed penis. On necropsy, numerous white nodules/plaques were found on the lungs, omentum, and multiple lymph nodes, as well as several ulcerations and cauli°ower-like growths throughout the glans penis to the internal fold. Histologically, the white nodules/plaques were composed of similar neoplastic squamous cells, which were immunostained positive for cytokeratin (CK), CK 5/6, and P63. The cauli°ower-like growths were diagnosed as squamous papilloma, inverted papilloma, and penile squamous cell carcinoma (PSCC). It is speculated that the lung metastasis and peritoneal carcinomatosis in this case are derived from the PSCC. The lesion tissues from the penis and omentum were characterized negative, by polymerase chain reaction, for Equus caballus papillomavirus 2 (EcPV2). This¯nding suggests that the penile lesions may have been irrelevant to the EcPV2, further implying that multiple pathogeneses exist for the development of an equine PSCC.

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Skin cancer and papillomaviruses in cattle

Cited by 9 publications

References 18 publications

A survey of tumors affecting cattle, buffaloes and sheep, in El-Dakahlyia Governorate

A survey of tumors affecting cattle, buffaloes and sheep, in El-Dakahlyia Governorate

Detection of papillomavirus in equine periocular and penile squamous cell carcinoma

A Penile Squamous Cell Carcinoma With Systemic Metastasis in a Thoroughbred Horse

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