Skin Cancer, Climate Change, and Opportunities for Dermatologists

Flynn, Michael Seth; Cooper, B.; Rundle, Chandler W.; Anderson, Jaclyn B.; Laughter, Melissa R.; Presley, Colby L.; Otchere, Elaine; Stamey, Christopher

doi:10.1007/s13671-023-00390-z

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…role of environmental components, including pollution, outdoor activities, radiation exposure, and climate changes, has been studied concerning skin cancer [12,13]. Wheeler et al (2013), examined the correlation between skin cancer rates and three factors: Radon, Arsenic, and sunshine hours in England.…”

Section: Geospatial Patterns Of Non-melanoma Skin Cancer In Relation ...mentioning

confidence: 99%

“…In this regard, various types of skin cancer are significantly linked to environmental conditions and the level of ultraviolet (UV) radiation exposure [ 11 ]. The role of environmental components, including pollution, outdoor activities, radiation exposure, and climate changes, has been studied concerning skin cancer [ 12 , 13 ]. Wheeler et al (2013), examined the correlation between skin cancer rates and three factors: Radon, Arsenic, and sunshine hours in England.…”

Section: Introductionmentioning

confidence: 99%

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Geospatial Patterns of Non-Melanoma Skin Cancer in Relation to Climate Changes in Iran

Aryan Kya

2024

Asian Pac J Cancer Prev

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Objective:The purpose of this study is to examine the impact of climate change factors on the incidence of skin cancer in Iran. Methods: The statistical population for this study comprises skin cancer patients in Iran. All other data used in this research were extracted from Remote Sensing imagery, including Ultraviolet ray, Relative humidity, Cloud cover, incoming short-wave flux, elevation, and total hours of sunshine. Initially, spatial autocorrelation analysis and cluster patterns were calculated using General G and Moran's I indices. Subsequently, a Geographically Weighted Regression Model was used to establish a regression relationship between the climate change data and the detection and forecasting rate of skin cancer. Finally, the model's accuracy was evaluated by estimating the detection coefficient between the reality map and the forecasting map. Results: The study found that UV radiation and relative humidity exhibit the highest positive and negative correlation, respectively, with the skin cancer rate in Iran. Geostatistical analysis revealed a clustered spatial distribution of skin cancer rates, and the proposed GWR model demonstrated high accuracy in predicting the skin cancer rate. The results indicate the highest positive correlation (+0.51) for UV ray and the most negative correlation (-0.43) for relative humidity. The Geostatistical analysis reveals spatial autocorrelation, cluster patterns, and non-randomness of the data. Conclusion: The detection rate of skin cancer increases from north to south and from west to east.

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Section: Geospatial Patterns Of Non-melanoma Skin Cancer In Relation ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Geospatial Patterns of Non-Melanoma Skin Cancer in Relation to Climate Changes in Iran

Aryan Kya

2024

Asian Pac J Cancer Prev

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Development of 5-fluorouracil/etoposide co-loaded electrospun nanofibrous scaffold for localized anti-melanoma therapy

Shojaei,

Doostan,

Mohammadi Motlagh

et al. 2024

Journal of Applied Biomaterials & Functional Materials

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Nanofibrous scaffolds have emerged as promising candidates for localized drug delivery systems in the treatment of cutaneous cancers. In this study, we prepared an electrospun nanofibrous scaffold incorporating 5-fluorouracil (5-FU) and etoposide (ETP) for chemotherapy targeting melanoma cutaneous cancer. The scaffold was composed of polyvinyl alcohol (PVA) and chitosan (CS), prepared via the electrospinning process and loaded with the chemotherapeutic agents. We conducted relevant physicochemical characterizations, assessed cytotoxicity, and evaluated apoptosis against melanoma A375 cells. The prepared 5-FU/ETP co-loaded PVA/CS scaffold exhibited nanofibers (NFs) with an average diameter of 321 ± 61 nm, defect-free and homogenous morphology. FTIR spectroscopy confirmed successful incorporation of chemotherapeutics into the scaffold. Additionally, the scaffold demonstrated a hydrophilic surface, proper mechanical strength, high porosity, and efficient liquid absorption capacity. Notably, sustained and controlled drug release was observed from the nanofibrous scaffold. Furthermore, the scaffold significantly increased cytotoxicity (95%) and apoptosis (74%) in A375 melanoma cells. Consequently, the prepared 5-FU/ETP co-loaded PVA/CS nanofibrous scaffold holds promise as a valuable system for localized eradication of cutaneous melanoma tumors and mitigation of adverse drug reactions associated with chemotherapy.

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Skin Cancer, Climate Change, and Opportunities for Dermatologists

Cited by 2 publications

References 30 publications

Geospatial Patterns of Non-Melanoma Skin Cancer in Relation to Climate Changes in Iran

Geospatial Patterns of Non-Melanoma Skin Cancer in Relation to Climate Changes in Iran

Development of 5-fluorouracil/etoposide co-loaded electrospun nanofibrous scaffold for localized anti-melanoma therapy

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