Skin Capillary Density and Microvascular Reactivity in Obese Subjects with and without Metabolic Syndrome

Francischetti, E. A.; Tibiriçá, Eduardo; Silva, Elizabete Goes da; Rodrigues, Elba; Celoria, Bruno Miguel Jorge; Abreu, Virgínia Genelhu de

doi:10.1016/j.mvr.2011.01.002

Cited by 54 publications

(47 citation statements)

References 28 publications

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“…To 16 or in vivo in the skin microcirculation. 5,15 These discrepancies could be explained by the inclusion of different tissues, or, a low number of participants in the first study. 16 In the other 2 studies, 5,15 the lack of insulin resistance or T2D among participants that was associated with the absence of cutaneous vascular dysfunction may have limited the capacity to describe smooth muscle dysfunction in MetS.…”

Section: Discussionmentioning

confidence: 99%

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Metabolic Syndrome Individuals With and Without Type 2 Diabetes Mellitus Present Generalized Vascular Dysfunction

Walther

Obert

Dutheil

et al. 2015

ATVB

110

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Objectives— The first objective of this study was to demonstrate differences within endothelial-dependent and endothelial-independent vasoreactivity in macro- and microcirculation beds among patients with metabolic syndrome (MetS) with and without type 2 diabetes mellitus (T2D) compared with healthy counterparts. The second objective was to determine relationships among the function of macro- and microvascular systems and abdominal adiposity, as well as inflammatory markers in the 3 groups. Approach and Results— Cross-sectional analyses of 53 patients with MetS without T2D and 25 with T2D, as well as aged 40 years and sex-matched healthy controls included microvascular (cutaneous blood flow measured with laser Doppler flowmetry in response to iontophoresis of acetylcholine and sodium nitroprusside), and macrovascular reactivity (flow-mediated dilation and nitrate-mediated dilation) along with anthropometric measures, plasma glucose, and insulin and inflammatory markers. Compared with controls, MetS participants showed depressed endothelial function of both micro- and macrocirculation beds. T2D in patients with MetS revealed an exacerbated vascular smooth muscle dysfunction in micro- and macrocirculation compared with MetS without T2D. Indices of micro- and macrocirculation were predominantly inversely related to abdominal fat and inflammatory markers. Conclusions— MetS was associated with endothelial-dependent and endothelial-independent dysfunction, affecting both the macro- and the microvascular systems. Participants with diabetes mellitus demonstrated the most severe smooth muscle dysfunction. The presence of central abdominal fat and systemic inflammation seems implicated in the pathogenesis of vascular dysfunctions in MetS.

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Section: Discussionmentioning

confidence: 99%

“…Skin microvascular abnormalities in response to ischemia have been observed in individuals with MetS. 12,13 More comprehensive studies have also observed endothelium-dependent dysfunction at a cutaneous 5,14,15 and subcutaneous levels. 16 However, only 1 study 14 has also reported smooth muscle cell dysfunction in the skin microcirculation.…”

mentioning

confidence: 99%

Metabolic Syndrome Individuals With and Without Type 2 Diabetes Mellitus Present Generalized Vascular Dysfunction

Walther

Obert

Dutheil

et al. 2015

ATVB

110

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“…Capillary density, i.e., the number of perfused capillaries per square millimeter of skin area, was assessed by high-resolution intra-vital color microscopy (Moritex, Cambridge, UK), as previously described and validated (Antonios et al, 1999c;Debbabi et al, 2006;Francischetti et al, 2011;Kaiser et al, 2013;Tibirica et al, 2007b). We used a video-microscopy system with an epi-illuminated fiberoptic microscope containing a 100-W mercury vapor lamp light source and an M200 objective with a final magnification of 200×.…”

Section: Capillaroscopy By Intra-vital Microscopymentioning

confidence: 99%

Reduced systemic microvascular density and reactivity in individuals with early onset coronary artery disease

Tibiriçá

Souza

Lorenzo

et al. 2015

Microvascular Research

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“…Apparently, waist circumference and body mass index do not affect microvascular function as assessed here. However, earlier reports have shown that microvascular vasomotion 78 , post-occlusive reactive hyperemia 79 , and insulin-mediated vasodilation 63 are indeed impaired in obese individuals. Mechanistically, higher waist circumference and/or body mass index may induce microvascular dysfunction systemically, via an increase in circulating adipose tissue-derived factors, such as tumor necrosis factor-α and free fatty acids, and/or a decrease in the anti-inflammatory adipokine adiponectin 63 , which may consequently impair insulin-mediated vasodilation 63 .…”

Section: Main Findings and Their Interpretationmentioning

confidence: 87%

“…The bold black arrows indicate directions of the associations as hypothesized in this dissertation. Note that the direction of the associations of hyperglycemia (including prediabetes and type 2 diabetes) 54 , low levels of physical activity 54 , and some of the other cardiovascular risk factors (such as hypertension 78 and dyslipidemia 79 ) with microvascular (endothelial) function can hypothetically also be reversed (bold gray arrows).…”

Section: Aims and Outline Of This Dissertationmentioning

confidence: 99%

Determinants of microvascular function in individuals with and without type 2 diabetes

Sörensen¹

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Citation for published version (APA):Sörensen, B. M. (2018). Determinants of microvascular function in individuals with and without type 2 diabetes: a population-based approach. https://doi.org/10.26481/dis.20180131bms Document status and date:Published: 01/01/2018 DOI:10.26481/dis.20180131bms Document Version:Publisher's PDF, also known as Version of record Please check the document version of this publication:• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:www.umlib.nl/taverne-license Take down policyIf you believe that this document breaches copyright please contact us at:repository@maastrichtuniversity.nl providing details and we will investigate your claim. Download date: 29 Mar. 2019Determinants of microvascular function in individuals with and without type 2 diabetes: a population-based approach © Ben Sörensen, Maastricht 2017 No part of this book may be reproduced or transmitted in any form or by any means, without prior permission in writing by the author, or when appropriate, by the publishers of the publications. ). Macrovascular and microvascular diseases impose a substantial burden on patients, their surroundings, and health care systems. Therefore, there is a need to understand their causes, in order to identify targets for treatment and prevention. Microvascular dysfunction has been shown to be associated with the aforementioned diseases of microvascular origin, and therefore may be an important underlying mechanism [5][6][7][8][9][10] . This dissertation will further focus on determinants of microvascular dysfunction in order to understand its pathophysiology better. Microvascular, as opposed to macrovascular research comprises a relatively new and growing field. This is predomi...

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Skin Capillary Density and Microvascular Reactivity in Obese Subjects with and without Metabolic Syndrome

Cited by 54 publications

References 28 publications

Metabolic Syndrome Individuals With and Without Type 2 Diabetes Mellitus Present Generalized Vascular Dysfunction

Metabolic Syndrome Individuals With and Without Type 2 Diabetes Mellitus Present Generalized Vascular Dysfunction

Reduced systemic microvascular density and reactivity in individuals with early onset coronary artery disease

Determinants of microvascular function in individuals with and without type 2 diabetes

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