AimTo conduct a quality evaluation of the literature for the prevention of skin damage caused by personal protective equipment among healthcare workers and to summarise the best‐evidence practice strategies to prevent it.DesignReview.MethodsTwo researchers retrieved the literature from Web of Science, Public Medicine, etc., from the establishment of the database until 24 June 2022. Appraisal of Guidelines, Research and Evaluation II was used to assess the methodological quality of the guidelines. Expert consensus was assessed by the 2016 version of the Australian Joanna Briggs Institute Evidence‐based Health Care Center corresponding evaluation standards. By tracking the original study, the quality of practice recommendations and best‐practice evidence information sheets were evaluated by the 2016 version of the Australian Joanna Briggs Institute Evidence‐based Health Care Center corresponding evaluation standards. The classification of evidence and recommendation level adopted the 2014 version of the Australian Joanna Briggs Institute evidence pre‐grading and recommending level system.ResultsA total of 5476 studies were retrieved after duplications were eliminated. After the quality evaluation, 10 qualified studies were finally included. All consisted of two guidelines, one best practice information sheet, five practice recommendations, and one expert consensus. The evaluation results of the guidelines were both B‐level recommendations. The consistency strength of expert consensus was moderate (Cohen's kappa coefficient = .571). Thirty best‐evidence practised strategies were compiled for four elements, including cleaning, moisturising, prophylactic dressings and others.ConclusionOur study evaluated the quality of the included studies and summarised the preventive measures of PPE‐related skin lesions according to the recommendation level. The main preventive measures were divided into 4 parts and 30 items. However, the associated literature was rare, and the quality was slightly low. More high‐quality research is needed to focus on healthcare workers' health and not just skin in the future.