Skin changes in the obese patient

Hirt, Penelope A.; Castillo, David; Yosipovitch, Gil; Keri, Jonette

doi:10.1016/j.jaad.2018.12.070

Cited by 130 publications

(121 citation statements)

References 231 publications

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“…A study conducted in the United States of America revealed a positive correlation between BMI and total IgE levels in children aged 2 to 19 years old [60]. Interestingly, this study showed a relationship between CRP and total IgE levels with age-adjustment, which was also confounded by BMI [60]. Since obesity is associated with atopy, reflecting an inflammatory state, it may be correlated with food allergies [62].…”

Section: Obesity and Allergymentioning

confidence: 60%

“…Obesity reportedly causes an increase in the levels of inflammatory mediators, potentially leading to immune disorders. In the obese state, the levels of plasma adiponectin, an anti-inflammatory adipokine, are low, thus enabling the natural onset of inflammation [60]. Leptin and adiponectin are adipokines secreted by white adipose tissue and are known to be related to obesity and involved in glucose and lipid metabolism.…”

Section: Obesity and Allergymentioning

confidence: 99%

“…Leptin and adiponectin are adipokines secreted by white adipose tissue and are known to be related to obesity and involved in glucose and lipid metabolism. Leptin, a hunger-inhibiting hormone predominantly made by adipocytes, is a mitogen factor for keratinocytes that also promotes fibroblast proliferation and positively correlates with body fat and body fat mass [60,61]. A study conducted in the United States of America revealed a positive correlation between BMI and total IgE levels in children aged 2 to 19 years old [60].…”

Section: Obesity and Allergymentioning

confidence: 99%

“…Leptin, a hunger-inhibiting hormone predominantly made by adipocytes, is a mitogen factor for keratinocytes that also promotes fibroblast proliferation and positively correlates with body fat and body fat mass [60,61]. A study conducted in the United States of America revealed a positive correlation between BMI and total IgE levels in children aged 2 to 19 years old [60]. Interestingly, this study showed a relationship between CRP and total IgE levels with age-adjustment, which was also confounded by BMI [60].…”

Section: Obesity and Allergymentioning

confidence: 99%

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Crosstalk Among Circadian Rhythm, Obesity and Allergy

Orihara

Haraguchi

Shibata

2020

IJMS

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The circadian clock system works not only as a cellular time-keeper but also as a coordinator for almost all physiological functions essential to maintaining human health. Therefore, disruptions or malfunctions of this system can cause many diseases and pre-symptomatic conditions. Indeed, previous studies have indicated that disrupted clock gene expression rhythm is closely related to obesity, and that allergic diseases can be regulated by controlling peripheral clocks in organs and tissues. Moreover, recent studies have found that obesity can lead to immune disorders. Accordingly, in this review, we assess the connection between obesity and allergy from the point of view of the circadian clock system anew and summarize the relationships among the circadian clock system, obesity, and allergy.

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Section: Obesity and Allergymentioning

confidence: 60%

Section: Obesity and Allergymentioning

confidence: 99%

Section: Obesity and Allergymentioning

confidence: 99%

Section: Obesity and Allergymentioning

confidence: 99%

See 2 more Smart Citations

Crosstalk Among Circadian Rhythm, Obesity and Allergy

Orihara

Haraguchi

Shibata

2020

IJMS

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“…Although this requires experimental confirmation by measuring inactive and active forms of VitD locally, and VitD-activating enzymes in immune cells, our results of tolDC and Treg induction (Figures 2, 4) and atheroprotection (Figure 7) are consistent with the idea of local activation of cholecalciferol upon sc administration. This is of translational relevance, since obesity associates to skin inflammatory conditions (55) and also to poor VitD status due to liver dysfunction (56). Thus, sc administration of cholecalciferol under inflammatory environments could assure sufficient 25-hydroxy and 1,25-hydroxy VitD local availability for tolDC-conditioning and Treg induction.…”

Section: Discussionmentioning

confidence: 99%

Reformulating Small Molecules for Cardiovascular Disease Immune Intervention: Low-Dose Combined Vitamin D/Dexamethasone Promotes IL-10 Production and Atheroprotection in Dyslipidemic Mice

et al. 2020

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Ospina-Quintero et al. Regulatory Cell-Inducing Small Molecule Formulation non-immunosuppressive, low-dose of VitD/Dexa, administered subcutaneously and repetitively, exerts atheroprotective effects in dyslipidemic mice, apparently due to the induction of an IL-10-producing network of lymphoid and myeloid immune cells. These well known, widely available, and inexpensive small molecules can be easily coformulated into a simple and accessible agent with a potential use as a prophylactic or therapeutic immune intervention for CVD and other chronic inflammatory diseases.

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Pulsed electromagnetic fields used in regenerative medicine: An in vitro study of the skin wound healing proliferative phase

Bedja‐Iacona,

Scorretti,

Ducrot

et al. 2024

Bioelectromagnetics

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Numerous studies have demonstrated the efficacy of extremely low frequency‐pulsed electromagnetic fields (ELF‐PEMF) in accelerating the wound healing process in vitro and in vivo. Our study focuses specifically on ELF‐PEMF applied with the Magnomega® device and aims to assess their effect during the main stages of the proliferative phase of dermal wound closure, in vitro. Thus, after the characterization of the EMFs delivered by the Magnomega® unit, primary culture of human dermal fibroblasts (HDFs) were exposed, or not for the control culture, to 10–12 and 100 Hz ELF‐PEMF. These parameters are used in clinical practice by physiotherapists in order to enhance healing of dermal lesions in patients. HDFs proliferation was first assessed and revealed an increase in the expression of one of the two genetic markers of cell proliferation tested (PCNA and MKI67), after initial exposure of the cells to 10–12 Hz PEMF. Next, migration of HDFs was investigated by performing scratch assays on HDF layers. The observed wound closure kinetics corroborate the early organization of actin stress fibers that was revealed in the cytoplasm of HDFs exposed to 100 Hz ELF‐PEMF. Also, maturation of HDFs into myofibroblasts was significantly increased in cells exposed to 10–12 or to 100 Hz PEMF. The present study is the first to demonstrate, in vitro, an early stimulation of HDFs, after their exposure to ELF‐PEMF delivered by the Magnomega® device, which could contribute to an acceleration of the wound healing process.

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Skin changes in the obese patient

Cited by 130 publications

References 231 publications

Crosstalk Among Circadian Rhythm, Obesity and Allergy

Crosstalk Among Circadian Rhythm, Obesity and Allergy

Reformulating Small Molecules for Cardiovascular Disease Immune Intervention: Low-Dose Combined Vitamin D/Dexamethasone Promotes IL-10 Production and Atheroprotection in Dyslipidemic Mice

Pulsed electromagnetic fields used in regenerative medicine: An in vitro study of the skin wound healing proliferative phase

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