Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy

Brincat, M.; Versi, Eboo; Cf, Moniz

doi:10.1016/0378-5122(88)90119-3

Cited by 65 publications

(106 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are surprising; previous uncontrolled studies report higher levels of skin collagen when postmenopausal women take hormone replacement treatment for two to 10 years 15 , this could be occurring secondary to increased collagen synthesis 16 or inhibition of collagen loss 17 . Our study, analysing vaginal tissue, has shown the converse over a six-month treatment interval, with a significant drop in total vaginal collagen occurring after oestrogen therapy.…”

Section: Discussioncontrasting

confidence: 54%

The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence

Jackson¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Objective To determine whether oestrogen replacement will produce an improvement in the quantity, or quality, of pelvic collagen in postmenopausal women.Design A prospective double-blind placebo controlled trial of oestrogen therapy.Setting Southmead Hospital, Bristol, UK.Population Fifty-five postmenopausal women with a urodynamic diagnosis of genuine urinary stress incontinence.Methods Randomisation to a six-month, double-blind, placebo-controlled, trial of oestradiol valerate 2mg once daily. A 10mg -30mg periurethral biopsy was taken from the vaginal epithelium before and after treatment. Tissue was analysed for total collagen content, intermolecular cross-links, advanced glycation end-products, collagen type ratios and matrix metalloproteinase (MMP) activity.Results Forty-nine women completed the trial of whom 26 received oestrogen and 23 received placebo. When compared with placebo, oestrogen treatment resulted in significant decreases in total collagen ( P ¼ 0.0054), the mature cross-link HHL ( P ¼ 0.0009) and the advanced glycation end-product NFC-1 ( P ¼ 0.0009).There was a significant rise in the immature cross-link HLKNL ( P ¼ 0.0191). Oestrogen produced a significant increase in MMP-2 expression (Pro MMP-2, P ¼ 0.0017).Conclusions Six months treatment with oestrogen has profound effects upon pelvic collagen metabolism, stimulating collagen degradation via increased proteinase activity. While aged collagen is being lost, new collagen is synthesised as witnessed by the increase in the immature cross-links and the decrease in both mature cross-links and advanced glycation end-products. Collagen loss contradicts previous reports; perhaps aged collagen degradation is merely an early response to oestrogen stimulation. We have evidence of new collagen synthesis, and it may be that a longer treatment interval would show total collagen content increasing. Further studies within this field are warranted.

show abstract

Section: Discussioncontrasting

confidence: 54%

The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence

Jackson¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

show abstract

“…For women particularly in the post-menopausal years, acceleration of chronologic aging is enhanced by the loss of estrogen, which causes a rapid loss of collagen during the first 5 years after menopause (Brincat et al, 1983;Brincat et al, 1985;Brincat et al, 1987;Brincat, 2000). It is assumed that phytoestrogens such as soy isoflavones may mimic the effects of estrogen in skin and reduce skin changes in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Effect of a novel dietary supplement on skin aging in post-menopausal women

2006

View full text Add to dashboard Cite

Objective: The aim of the present study was to quantify the effects on skin in post-menopausal women of a novel dietary supplement (Imedeen Prime Renewalt) that contained soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract. Design: The study was a 6-month double blind, placebo controlled, randomized study on healthy post-menopausal females. Setting: The study was performed at a commercial Contract Research Organisation (TJ Stephens & Associates Inc., TX, USA). Interventions: Two tablets of Imedeen Prime Renewalt or placebo were given twice daily for 6 months. Subjects: Thirty-eight (active group) and 42 (placebo group) subjects completed the study out of 100. Results: Clinical grading showed that the active group had a significantly greater improvement (Po0.05) compared to placebo for the face after 6 months treatment for: forehead, periocular and perioral wrinkles, mottled pigmentation, laxity, sagging, under eye dark circles and overall apperance; skin on the décolletage after 2, 3 and 6 months treatment and skin on the hand after 3 and 6 months treatment. Photo evaluation showed that the active group had a significantly greater improvement (Po0.05) on the face after 3 and 6 months for several parameters. Ultrasound measurements showed that the active group had a significantly greater improvement (Po0.0001) for density measurements after 6 months treatment. Conclusion: In summary, this novel dietary supplement, Imedeen Prime Renewalt, provides improved condition, structure and firmness of the skin in post-menopausal women after 6 months.

show abstract

“…112, 113 Estrogen therapy (HRT) may prevent collagen loss and can stimulate synthesis of collagen in those that have lower initial collagen levels. 114, 115 There is also a relationship between estrogen deprivation and degenerative changes of dermal elastic tissue. 116, 117 There is some evidence M A N U S C R I P T A C C E P T E D …”

Section: Womenmentioning

confidence: 99%