2017
DOI: 10.1016/j.jid.2017.07.834
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Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy

Abstract: Atopic dermatitis (AD) has a well-established association with skin colonization or infection by Staphylococcus aureus, which can exacerbate the disease. However, a causal relationship between specific changes in skin colonization during the first years of life and AD development still remains unclear. In this prospective birth cohort study, we aimed to characterize the association between skin colonization and AD development in 149 white infants with or without a family history of atopy. We assessed infants c… Show more

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Cited by 206 publications
(179 citation statements)
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“…A prospective observational study of culturable skin bacteria of children from birth to age 2 has shown that S. aureus colonization precedes the onset of the disease (Meylan et al, 2017), while another recent bacterial metagenomic study before onset of AD has shown the bacterial community can be protective (Kennedy et al, 2017). Additionally, whole-genome sequencing of skin swabs from AD subjects has shown again that S. aureus is increased and clonal on AD skin and suggested these clones promote changes in the skin of mice (Byrd et al, 2017).…”
mentioning
confidence: 99%
“…A prospective observational study of culturable skin bacteria of children from birth to age 2 has shown that S. aureus colonization precedes the onset of the disease (Meylan et al, 2017), while another recent bacterial metagenomic study before onset of AD has shown the bacterial community can be protective (Kennedy et al, 2017). Additionally, whole-genome sequencing of skin swabs from AD subjects has shown again that S. aureus is increased and clonal on AD skin and suggested these clones promote changes in the skin of mice (Byrd et al, 2017).…”
mentioning
confidence: 99%
“…Colonization with toxigenic S. aureus has been found to lead to a shift in the intradermal T-cell receptor Vβ repertoire that corresponds to the respective superantigen-responsive T-cell subsets and correlates with disease severity in AD children [114]. In infants, the presence of S. aureus on the skin at 3 months has been found to correlate with later development of AD [115]. Notably, the prevalence of S. aureus has been found to be increased at the onset of AD and already 2 months before an outbreak [115].…”
Section: Pathogenenic Mechanismsmentioning
confidence: 99%
“…In infants, the presence of S. aureus on the skin at 3 months has been found to correlate with later development of AD [115]. Notably, the prevalence of S. aureus has been found to be increased at the onset of AD and already 2 months before an outbreak [115]. …”
Section: Pathogenenic Mechanismsmentioning
confidence: 99%
“…However, a potential causal association of AD with the microbiome was seen with other nonidentified members of the Staphylococcus genus, and their presence correlated with a better outcome of AD (Kennedy et al, 2017). Meylan et al (2017) now present a larger longitudinal study of 149 infants who were sampled in the axillae and the antecubital fossae seven times during the first 2 years of life. AD developed in 36 of these subjects.…”
Section: S Aureus Colonization In Longitudinal Studiesmentioning
confidence: 99%
“…This study detected S. aureus colonization before clinical onset of AD. Furthermore, another member of the Staphylococcus genus, Staphylococcus hominis , was observed to be statistically less abundant in AD and potentially protective (Meylan et al, 2017). …”
Section: S Aureus Colonization In Longitudinal Studiesmentioning
confidence: 99%