Skin contamination by radiopharmaceuticals and decontamination strategies

Bolzinger, Marie‐Alexandrine; Bolot, C.; Galy, G.; Chabanel, A.; Pelletier, Jocelyne; Briançon, Stéphanie

doi:10.1016/j.ijpharm.2010.09.027

Cited by 26 publications

(26 citation statements)

References 48 publications

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“…). This is in agreement with several authors who reported the permeation of these inorganic cations in spite of their unfavourable physicochemical properties . Both Mg 2+ and Ca 2+ are considered hard metal ions of low polarizability because they retain valence electrons close to their nucleus.…”

Section: Resultssupporting

confidence: 92%

The effect of vehicle on skin absorption of Mg²⁺ and Ca²⁺ from thermal spring water

Tarnowska

Briançon

Azevedo

et al. 2020

Intern J of Cosmetic Sci

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OBJECTIVE: Thermal spring waters (TSW) are commonly used as active ingredients in cosmetics. Their biological activities directly depend on the ionic composition of the spring. However, in order to exhibit beneficial properties, the minerals need to reach viable skin layers. The present study addresses the incorporation of marketed TSW in model cosmetic formulations and the impact of the formulation on skin absorption of magnesium and calcium ions that are known to improve skin barrier function. METHODS: Marketed TSW was introduced into five formulations. Liposomes were prepared using saturated or unsaturated phospholipids mixed with cholesterol by the thin layer evaporation technique. Emulsions water-in-oil (W/O), oil-in-water (O/W) or double: water-in-oil-in-water (W/O/W) were prepared by high-shear mixing. Skin absorption of Mg 2+ and Ca 2+ from those formulations was studied in vitro using static Franz diffusion cells under infinite dose condition and under occlusion of the apparatus. RESULTS: Mg 2+ and Ca 2+ penetrate skin samples from TSW. Encapsulating TSW into double emulsion (TSW/O/W) increased skin absorption of both cations of interest and kept the Ca 2+ /Mg 2+ ratio equal to that of TSW in each skin layer. The dermal absorption of Mg 2+ from the double emulsion departs from both single emulsions. Application of liposome suspension improved the skin absorption of Ca 2+ while keeping constant that of Mg 2+ , leading to unbalanced Ca 2+ /Mg 2+ ratio inside skin. CONCLUSION: The beneficial effects of TSW are not only due to their action on the skin surface. Their active components, especially Ca 2+ and Mg 2+ cations, reach viable skin layers in a formulation-dependent manner. The distribution of ions inside skin depends on the type of formulation. 248

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Section: Resultssupporting

confidence: 92%

The effect of vehicle on skin absorption of Mg²⁺ and Ca²⁺ from thermal spring water

Tarnowska

Briançon

Azevedo

et al. 2020

Intern J of Cosmetic Sci

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“…Additional Monte Carlo simulations show that at this depth the skin dose rate is reduced by 80% for 99m Tc and by 35% for 18 F. However, one should not jump to conclusions by reducing the values in Fig. 5 significantly, as the poor efficacy of decontamination found in this study and other skin permeation studies [15,16] suggest a shorter distance between the source and the basal layer of the epidermis. P values for differences between Na 99m TcO 4 and 99m Tc-HDP, 99m Tc-tetrofosmin and 18 F-FDG, respectively, using the same decontamination agent.…”

Section: Discussionmentioning

confidence: 48%

“…The latter study reported values for the remaining activity of Na 99m TcO 4 , which are comparable to the values in Table 4, whereas no improvement could be found when applying Radiacwash. Bolzinger et al [15] evaluated the percutaneous penetration of different radiopharmaceuticals and found that Na 99m TcO 4 permeates very well because of its oxidation state and that the skin has a poor affinity for the 99m TcO 4 -ion. They also concluded that the role of dedicated contamination agents is unclear and that more research is needed in this field.…”

Section: First Decontaminationmentioning

confidence: 99%

Skin contamination of nuclear medicine technologists

Covens

Berus

Caveliers³

et al. 2012

Nuclear Medicine Communications

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Skin contamination can be found in large doses on the skin among nuclear medicine technologists. Single contaminations can result in local skin doses exceeding the yearly dose limit because of the contribution of electrons at shallow depths and should therefore be prevented at any time. The use of a neutral hand soap should generally be preferred during decontamination. A general simplified method is proposed to assess the skin dose after a contamination with 99mTc-labelled radiopharmaceuticals or 18F-fluorodeoxyglucose.

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“…The contaminated area was either outlined completely or the corners were marked with permanent markers to indicate the area of contamination. The experimental models were then allowed to air dry at room temperature at a predefined time period (5,15,30,45, and 60 minutes), as applicable. Each contaminant was applied separately.…”

Section: Contamination Of the Experimental Modelsmentioning

confidence: 99%

Scintigraphic Evaluation of Decontamination Lotion for Removal of Radioactive Contamination From Skin

Rana

Dutta

Sharma

et al. 2014

Disaster med. public health prep.

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The formulated lotion assisted in the effective removal of radiocontaminants by decontaminating the radionuclides. Moreover, minimal and easily manageable radioactive waste was generated by this process. Further investigation regarding the infusion of formulated lotion into ready-to-use skin wipes for self-decontamination may be useful for mass casualty scenarios. (Disaster Med Public Health Preparedness. 2014;0:-).

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Skin contamination by radiopharmaceuticals and decontamination strategies

Cited by 26 publications

References 48 publications

The effect of vehicle on skin absorption of Mg²⁺ and Ca²⁺ from thermal spring water

The effect of vehicle on skin absorption of Mg²⁺ and Ca²⁺ from thermal spring water

Skin contamination of nuclear medicine technologists

Scintigraphic Evaluation of Decontamination Lotion for Removal of Radioactive Contamination From Skin

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Skin contamination by radiopharmaceuticals and decontamination strategies

Cited by 26 publications

References 48 publications

The effect of vehicle on skin absorption of Mg2+ and Ca2+ from thermal spring water

The effect of vehicle on skin absorption of Mg2+ and Ca2+ from thermal spring water

Skin contamination of nuclear medicine technologists

Scintigraphic Evaluation of Decontamination Lotion for Removal of Radioactive Contamination From Skin

Contact Info

Product

Resources

About

The effect of vehicle on skin absorption of Mg²⁺ and Ca²⁺ from thermal spring water

The effect of vehicle on skin absorption of Mg²⁺ and Ca²⁺ from thermal spring water