2020
DOI: 10.3390/molecules25184324
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Skin Damages—Structure Activity Relationship of Benzimidazole Derivatives Bearing a 5-Membered Ring System

Abstract: In the search for scaffolds for multifunctional compounds we investigated the structure activity relationship of a class of benzimidazole derivatives bearing 5-membered ring. The newly synthesized and the already known compounds were divided into three classes that present different substituent at 5 position of the benzimidazole ring (-H, -COOH or –SO3H) and different heterocycle at position 2 (thiophene, furan or pyrrole). All the derivatives were synthesized and tested to determine their photoprotective prof… Show more

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Cited by 14 publications
(16 citation statements)
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“…As for the previously reported benzimidazole derivatives [ 31 ], position 6 unsubstituted benzothiazole compounds (compounds 8a , 9a and 10a ), in general, showed the best values of inhibition. In particular, compounds 9a and 10a showed a good inhibition of the growth of all five dermatophytes (with percentages of inhibition between 50% and 75%).…”
Section: Resultssupporting
confidence: 73%
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“…As for the previously reported benzimidazole derivatives [ 31 ], position 6 unsubstituted benzothiazole compounds (compounds 8a , 9a and 10a ), in general, showed the best values of inhibition. In particular, compounds 9a and 10a showed a good inhibition of the growth of all five dermatophytes (with percentages of inhibition between 50% and 75%).…”
Section: Resultssupporting
confidence: 73%
“…From the results obtained, it was possible to deduce that the order of protection against UVB of the newly synthesized benzothiazole derivatives is the following: furan-> pyrrole-> thiophene-derivatives, as previously seen for the benzimidazole analogue derivatives [ 31 ].…”
Section: Resultsmentioning
confidence: 54%
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“…These included pyrrole, thiazole, pyrazole, benzimidazole, pyridine, pyrimidine, triazine and acridine derivatives, for most of them with some biological activity being unraveled. Thus, several compounds were synthetized with a benzimidazole scaffold connected to five-membered heterocycles, among which the 2-pyrrole derivative was found the most efficient as concerns its antioxidant, antifungal and antiproliferative activity, especially against human melanoma cells [ 2 ]. New paracyclophane derivatives bearing thiazole moieties were prepared and their anticancer activities were evaluated using nine human cancer cell lines [ 3 ].…”
mentioning
confidence: 99%