Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis

Reijsen, Frank C. van; Bruijnzeel-Koomen, Carla A.F.M.; Kalthoff, Frank; Maggi, Enrico; Romagnani, Sergio; Westland, J.K.T.; Mudde, Geert C.

doi:10.1016/0091-6749(92)90070-i

Cited by 371 publications

(199 citation statements)

References 28 publications

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“…MDC levels were found to be elevated up to tenfold in the serum of patients with MF/SS or AD, whereas MDC serum levels in subjects with MS or CD were not significantly different to those found in healthy controls. Of note, MF/SS is a neoplastic condition characterized by the abnormal proliferation of T cells showing a Th2-like profile [11,12], and AD is considered as a Th2-dominated disorder [13,14]. By contrast, MS and CD are characterized by a Th1 predominance at level of target organs [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…MDC levels were measured in the sera of 8 subjects with MF/SS and of 14 subjects with AD, which are diseases characterized by prevalent expansion or activation of Th2 cells, respectively [11][12][13][14], as well as in the sera of 29 subjects with MS and of 15 subjects with CD, which are characterized by the prevalent activation of Th1 cells [15][16][17]. As a control, MDC was also measured in the sera of 31 sex-and age-matched normal individuals.…”

Section: Measurement In the Serum Of Normal Subjects And Subjectsmentioning

confidence: 99%

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Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: preferential association with the production of type 2 cytokines

et al. 2000

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Macrophage-derived chemokine (MDC), a potent chemoattractant for chronically activated Th2 lymphocytes, is constitutively expressed by dendritic cells, B cells, macrophages, and thymic medullary epithelial cells, whereas monocytes, NK cells, and T lymphocytes produce MDC only upon appropriate stimulation. In this study, we show in vitro MDC production also by activated T cells, which preferentially associate with the production of Th2 cytokines, IL-4, IL-5, and IL-6, and inversely correlate with the production of the Th1 cytokine, IFN-+ . Moreover, high levels of MDC were detected in the sera of the great majority of subjects suffering from mycosis fungoides/Sézary syndrome or atopic dermatitis, which are considered as disorders characterized by the predominant expansion and activation of Th2 cells, respectively. By contrast, serum MDC levels in subjects with multiple sclerosis or Crohn's disease, which are characterized by a Th1 predominance, did not differ significantly from those of healthy controls. Finally, MDC expression was detected in the skin biopsy specimens of subjects with atopic dermatitis, where it was expressed by both dendritic cells and T lymphocytes. Taken together, these findings suggest that MDC production by activated T cells may occur both in vitro and in vivo, particularly in association with Th2 cytokines, thus providing an important amplification circuit for Th2-mediated responses.

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Section: Discussionmentioning

confidence: 99%

Section: Measurement In the Serum Of Normal Subjects And Subjectsmentioning

confidence: 99%

Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: preferential association with the production of type 2 cytokines

et al. 2000

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“…Electron microscopy showed that some epidermal eosinophils were in close contact with Langherans cells, thus suggesting a cell-cell interaction. Recent data have confirmed the prevalent role of Der pl in PT lesions, and the close association of the allergen with Th2 lymphocytes [42]. It has been speculated that immediately after PT some allergens penetrate the epidermis, bind the IgE molecules on mast cells in the dermis and induce an immediate type reaction.…”

Section: The Role Of Inhalant Allergensmentioning

confidence: 73%

“…Mast cell release eosinophil chemotactic factors and some of the infiltrating eosinophils become activated [41]. As already discussed, recent studies demonstrated that in the skin lesions of AD patients' Der pl-specific T clones are Th2 lymphocytes expressing IL-4 and IL-5 and no IFN-α (42). On the contrary, in non atopic subjects Der pl-specific T-cell clones produced IFN-α and only in some case a minimal amount of IL-4 [43].…”

Section: The Role Of Inhalant Allergensmentioning

confidence: 87%

Atopic Dermatitis and Allergen Hypersensitivity: State of the Art

Cantani¹

2016

J Ped Moth Care

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The current growing enthusiasm for atopic dermatitis is clearly reflected in the range of current attitudes on the subject. What are considered to be its protean manifestations are frequent challenges to the pediatrician and other specialists working with children. AD may occur not only in man, but also in other vertebrates. However, it must be assumed that AD has always been an affection of our species. Hippocrates (460-370 BC) reported urticaria and gastrointestinal upset following cow's milk ingestion. Lucretius (98-55 BC) wrote that one man's meat is another man's poison. Galen (131-219) described allergy to goat's milk. At the turn of this century the first description of acute shock due to CM allergy (CMA) and fatal CMA were published. In his pioneer studies of food allergy (FA), Schloss was the first to evaluate skin tests for the diagnosis of FA. Since then, a vast array of symptoms and disorders has been attributed to FA, many of which occur with other conditions. In addition to this, the lack of a single, practical diagnostic test has contributed to the polarization of the scientific controversy between those who believe in and those who deny FA existence. Terminology has also been confusing. A correct use of definitions is necessary for a proper epidemiologic evaluation of the conditions and an accurate diagnostic and therapeutic approach. While this concept was fundamentally correct, it was also too easily weakened by ignoring this prerequisite to be fully acceptable, and this led to an equally disordered use of the term hypersensitivity, since allergy had become a word used to embrace all possible forms of adverse reactions. AD is associated with patchy, characteristically distributed areas of cutaneous eczema, with intense itching and subsequent lichenification of the skin. Cutaneous automic dysfunction (increased vasoconstriction) and xerosis (dryness of the skin) commonly occur in the affected children. In addition, profound immunological dysregulation with various immune alterations has been described in affected children. Most children produce IgE antibodies to a number of food and inhalants allergens, at the point that a minuscule offending quantity can trigger a reaction by skin contact or by inhalation.

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“…아토 피 피부염은 주로 가려움과 염증을 수반하는 만성 염증성 피 부질환으로써 [2], 아토피 피부염이 유발되는 원인은 명확하 게 밝혀지지 않았으나 유전적 소인, 면역학적 요인 및 환경 요인이 복합적으로 작용하여 발생하는 것으로 알려져 있다 [3][4][5]. 아토피 피부염의 발생에 있어 지금까지 보고된 면역학 적 특성으로는 혈중 IgE 항체 및 IL-4 cytokine의 분비량이 증 가하고 IFN-γ cytokine의 분비량은 감소하는 것으로, 질환 초 기에는 항원을 인식한 T 세포가 IL-4, IL-5 및 IL-13 cytokine 을 분비하여 [6,7] naive CD4+ T 세포가 Th 2 세포로 분화하 도록 조절하고, B 세포의 활성화가 촉진되어 IgE의 생성을 증가시킨다 [8,9]. 또한 IFN-γ 및 IL-12와 같은 Th 1 type의 cytokine을 감소시킨다 [10].…”

Section: 서론unclassified

Effect of Pine needle Ethanol Extracts on the Inhibitory Activity of Atopic Dermatitis

Jeong¹,

Kim²,

Jung³

et al. 2013

KSBB Journal

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The aim of this study was to examine inhibitory effects of pine needle ethanol extracts (PNEE) on atopic dermatitis (AD). To determine inflammatory activity PNEE was added to LPS-induced murine peritoneal macrophages for an in-vitro test. In addition, anti-AD test was carried out by spreading PNEE on the dorsal skin of 2,4-dinitrochlorobenzene (DNCB)-induced BALB/c mice. It was confirmed that the nitric oxide (NO) secretion was suppressed when 15 0 µg/mL of PNEE were added to LPS-induced murine peritoneal macrophages. Moreover, levels of TNF-α, IL-6, and IL-1β‚ were decreased. For the anti-AD test, PNEE alleviated symptoms of the erythema in DNCB-induced mice. Furthermore, the IFN-γ secretion of the group treated with PNEE was increased in splenocytes from DNCB-induced mice compared to the positive control, while IL-4 secretion diminished. Through these results, we can conclude that PNEE can inhibit AD by modulating the IFN-γ, IL-4 cytokines production and inhibiting inflammation.

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Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis

Cited by 371 publications

References 28 publications

Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: preferential association with the production of type 2 cytokines

Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: preferential association with the production of type 2 cytokines

Atopic Dermatitis and Allergen Hypersensitivity: State of the Art

Effect of Pine needle Ethanol Extracts on the Inhibitory Activity of Atopic Dermatitis

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