Skin disease: clinical indicator of immune status in human immunodeficiency virus (HIV) infection

Raju, P. V. Krishnam; Rao, G Raghurama; Ramani, T V

doi:10.1111/j.1365-4632.2004.02067.x

Cited by 57 publications

(58 citation statements)

References 18 publications

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“…(6)(7)(8)(9) It may be the presenting feature and a valuable clinical tool in staging and predicting progression of the disease. (10)(11)(12)(13)(14)(15) …”

Section: Introductionmentioning

confidence: 99%

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Swamiappan¹,

Vijayabhaskar²,

Subbaiya³

et al. 2016

jemds

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“…(6)(7)(8)(9) It may be the presenting feature and a valuable clinical tool in staging and predicting progression of the disease. (10)(11)(12)(13)(14)(15) …”

Section: Introductionmentioning

confidence: 99%

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Swamiappan¹,

Vijayabhaskar²,

Subbaiya³

et al. 2016

jemds

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“…In our study Molluscum contagiosum was reported as 5.19% which coincides with the findings of Kore et al 20 Among non-infectious manifestations, Xerosis was the most common and reported with prevalence of 31.37%, these findings were on contrary with findings of Raju who reported the prevalence as 22.17% in his study, but similar to Kumaraswamy et al who reported as 37% in his study. 21,22 Followed in next order, generalized pigmentation was observed with 19.61% prevalence and Seborrhoeic dermatitis in 23.53%. The prevalence of pigmentation and seborrhoeic dermatitis was considerably less than in other studies.…”

Section: Discussionmentioning

confidence: 99%

Mucocutaneous manifestations in newly diagnosed cases of HIV, correlation with CD4 counts and WHO staging at a tertiary care center

2017

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Background:Mucocutaneous infections have played an important role in initial diagnosis of HIV infection and in clinical staging of the disease. Mucocutaneous manifestations in HIV infected individuals are myriad and can serve as a main indicator of other problems. Health care personnel involved in HIV health care must therefore have a clear idea of type, pattern, and prevalence of skin diseases in their locality. The objective of the study was to determine the various mucocutaneous manifestations in newly diagnosed cases of HIV and to correlate them with CD4 cell counts. The manifestations and CD4 cell counts are correlated with WHO staging of the disease.Methods:Data was collected from all the newly diagnosed cases of HIV presenting to the Department of Dermatology. Thorough clinical examination was done and findings were noted. CD4 cell counts were performed by FACS counter and supportive laboratory tests were done for diagnosis of other skin manifestations.Results:250 cases were enrolled with males 148 and 102 females. Most common age group was middle age group and hetero sexual route was the most common route of transmission. Bacterial skin infections were more common and candidiasis was most common among fungal infections. Herpes zoster was most common in viral infections. Significant correlation was observed between CD4 cell counts and WHO clinical staging of disease. Majority of infections were more common at advanced stage of HIV.Conclusions:To conclude, HIV-related mucocutaneous manifestations are a good clinical clue in diagnosis of advanced stages of HIV. Most of these manifestations can serve as diagnostic and prognostic markers in HIV infection. Management of HIV related mucocutaneous manifestations should always be precluded with a screening of CD4 cell counts. A lowered CD4 cell counts will prolong the duration of treatment and may significantly alter the outcome of the disease.

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“…Previous studies show that dermatological manifestations are seen at every stage of HIV/ AIDS and are often the presenting feature 1 . These manifestations not only act as disease markers, but also reflect the underlying immune status 5 .…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism by which HIV-infected patients are prone to skin disease appears to be correlated with the degree of immunodeficiency 4 . Many skin diseases may in fact be considered valuable and sensitive indicators for the diagnosis of HIV and for monitoring disease progression and treatment efficacy 5,6 . The hallmark of HIV infection is a progressive, qualitative and quantitative deficiency of helper CD4 T lymphocyte which is needed for foreign antigen presentation and phagocytosis.…”

Section: Introductionmentioning

confidence: 99%

Study of Mucocutaneous Involvement in HIV in a Tertiary Care Centre

Leishangthem¹,

J.N.I.M.S.²

2018

jmscr

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Skin disease: clinical indicator of immune status in human immunodeficiency virus (HIV) infection

Abstract: There was an inverse relation between the CD(4) counts and the incidence and severity of skin diseases in the HIV/AIDS patients. Cutaneous manifestations of HIV can be considered as good clinical indicators to predict and access the underlying immune status in resource-poor countries.

Cited by 57 publications

References 18 publications

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Mucocutaneous manifestations in newly diagnosed cases of HIV, correlation with CD4 counts and WHO staging at a tertiary care center

Study of Mucocutaneous Involvement in HIV in a Tertiary Care Centre

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