Skin diseases in Asian individuals that you do not want to miss: A selection of unique or relatively more common conditions in Asian populations

Extranodal Natural Killer/T-cell Lymphoma Isolated to the Leg: A Case Report

“…ENKTL lesions may present as papules, subcutaneous nodules, erythema, and cellulitis-like or ulcerated plaques on the skin with a predilection for the extremities and trunk [1][2][3][4]. The disease predominantly affects middle-aged males with a higher incidence in Asian countries [5,6].…”

“…Histopathology typically demonstrates an angiocentric lymphoreticular infiltrate with deep tissue involvement [4][5][6]9]. Most commonly, NK cells are found in the dermis, while T-cells are rarely found [1]. The tumor causes vascular damage, leading to the characteristic necrotic clinical appearance [10].…”

“…Extranodal natural killer/T-cell lymphoma (ENKTL) is a subtype of non-Hodgkin's lymphoma, and it is further classified into nasal (primary upper nasopharynx involvement) and extranasal (primary peripheral involvement outside of the nasal region) types. There is a scarcity of data on this type of lymphoma, and it is exceedingly rare in North America [ 1 , 2 ]. The non-nasal cases are even more uncommon, with the skin being one of the more frequent sites of involvement [ 2 ].…”