Skin drug delivery using lipid vesicles: A starting guideline for their development

Guillot, Antonio José; Martínez-Navarrete, Miquel; Garrigues, Teresa María; Melero, Ana

doi:10.1016/j.jconrel.2023.02.006

Cited by 51 publications

(25 citation statements)

References 422 publications

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“…The skin is the interface which separates the body and the environment. In consequence, its main function is to offer a robust barrier against the penetration of external xenobiotics, substances, allergens, and microorganisms (Guillot et al, 2023). In addition, the skin plays other important roles, such as homeostasis maintenance-preventing the dehydration of the body, protection from the harmful effects of ultraviolet radiation, and interaction with the environment-since it presents different types of receptors sensitive to pressure changes, pain and temperature- (Brenner & Hearing, 2008;Kobayashi, 2015;Owens & Lumpkin, 2014;Sparr et al, 2013).…”

Section: Box 2 a Brief Review Of Human Skin Structurementioning

confidence: 99%

“…Nevertheless, these are rare exceptions, as the combination of all physicochemical properties must be optimal, and the axiom "the higher molecular weight of a drug, the more probability to fail in the passive skin absorption" is completely truthful. This fact could discourage the use of topical-local-and transdermal-systemic-strategies, but its potential benefits and advantages (Guillot et al, 2023), such as the good acceptance and compliance by patients (Alkilani et al, 2015), the large skin surface-around 20,000 cm 2 in adults- (Richardson, 2003), and the possibility to avoid the first pass effect, justify the efforts done to develop Transdermal Drug Delivery Systems (TDDS) (Prausnitz & Langer, 2008;Roberts et al, 2021) (Table 1). As a consequence, skin administration of many drugs has been possible thanks to this plethora of strategies, that modify the skin barrier function or change the physicochemical properties of molecules (Ramadon et al, 2022).…”

Section: Introduction: Nanoparticles Combined With Microneedle Arrays...mentioning

confidence: 99%

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Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects

Guillot

Martínez-Navarrete

Zinchuk-Mironova

et al. 2023

WIREs Nanomed Nanobiotechnol

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Transdermal delivery of drugs offers an interesting alternative for the administration of molecules that present certain troubles when delivered by the oral route. It can produce systemic effects or perform a local action when the formulation exerts an optimal controlled drug release or a targeted delivery to the specific cell type or site. It also avoids several inconveniences of the oral administration such as the hepatic first pass effect, gastric pH-induced hydrolysis, drug malabsorption because of certain diseases or surgeries, and unpleasant organoleptic properties. Nanomedicine and microneedle array patches (MAPs) are two of the trendiest delivery systems applied to transdermal research nowadays. However, the skin is a protective barrier and nanoparticles (NPs) cannot pass through the intact stratum corneum. The association of NPs and MAPs (NPs@MAPs) work synergistically, since MAPs assist NPs to bypass the outer skin layers, and NPs contribute to the system providing controlled drug release and targeted delivery. Vaccination and tailored therapies have been proposed as fields where both NPs and MAPs have great potential due to inherent characteristics. MAPs conception and easy use could allow selfadministration and therefore facilitate mass vaccination campaigns in undeveloped areas with weak healthcare services. Additionally, nanomedicine is being explored as a platform to personalize therapies in such an important field as oncology. In this work we show recent insights that prove the benefits of NPs@MAPs association and analyze the prospects and the discrete interest of the industry in NPs@MAPs, evaluating different limiting steps that restricts NPs@MAPs translation to the clinical practice.

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Section: Box 2 a Brief Review Of Human Skin Structurementioning

confidence: 99%

Section: Introduction: Nanoparticles Combined With Microneedle Arrays...mentioning

confidence: 99%

Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects

Guillot

Martínez-Navarrete

Zinchuk-Mironova

et al. 2023

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

show abstract

“…The penetration of TEs into the systemic circulation is mainly due to the electrostatic forces of the vesicle, such as increased zeta potential and increased net charge 103 . These electrostatic forces increase the adhesion of the TEs to the skin 98,104 . Thus, TEs can cross the epidermis and dermis and enter the systemic circulation.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

“…Once they reach the dermis, they can be absorbed into the lymphatic system and distributed throughout the body, thus being able to reach the systemic circulation. 104 Thus, TEs can cross the epidermis and dermis and enter systemic circulation. Figure 4 depicts the penetration capacity, primary penetration mechanism, and permeation capacity of TEs.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

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Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review

Chowdary,

Padmakumar,

Rengan

2023

MedComm – Biomaterials and Applications

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The growing need for innovative drug delivery systems has led to extensive research to address the limitations associated with conventional dosage forms. Lipid nanoparticles have become prominent as frontline nanocarriers for the delivery of drugs and vaccine formulations. However, the pursuit of new materials and modifications to improve lipid nanocarrier properties remains ongoing. In this context, transethosomes have gained attention as a promising solution, offering distinct advantages over traditional formulations. Transethosomes minimize plasma fluctuations, first‐pass metabolism, organ toxicity, and poor bioavailability. This comprehensive review provides an in‐depth exploration of transethosomes, starting with an overview of the impact of formulation components on their properties and effective targeting. This article delves into the production techniques and evaluation properties employed to ensure efficient drug delivery. A significant contribution of this review lies in the analysis of various routes of administration for transethosomes, including transdermal, transvaginal, pulmonary, and ocular delivery, showcasing the versatility of transethosome‐loaded with drugs and their potential to target specific tissues to achieve controlled release. Furthermore, the potential of functionalization and photodynamic therapy approaches to enhance drug delivery efficacy are explored. Overall, this review emphasizes the significant potentiality of transethosomes as a promising drug delivery system addressing the challenges associated with conventional drug delivery approaches.

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Transethosome‐Based Topical Administration Systems with Enhanced Penetration and Dual Actions for Treating EGFR‐Overexpressed Cutaneous Squamous Cell Carcinoma

Wang,

Tham,

Ding

et al. 2024

Adv Funct Materials

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Epidermal growth factor receptor (EGFR)‐overexpressing cutaneous squamous cell carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk compared to the conventional CSCC. While photodynamic therapy (PDT) is a promising way to treat CSCC, effectively administering photosensitizers to reach deeper skin malignancies remains a challenge. Herein, BE‐TEL is reported, a transethosome formulation designed to enhance skin and cutaneous tumor permeability, for targeted treatment of EGFR‐overexpressed CSCC. The formulation is co‐loaded with Erlotinib (Erb), a hydrophobic EGFR inhibitor, and BODIPY (BPY), a photosensitizer. Upon skin penetration and subsequent exposure to 660 nm light, BE‐TEL induces tumor cell apoptosis by reactive oxygen species (ROS) generation and EGFR pathway inhibition. ROS and Erb‐induced metabolic oxidative stress by upregulating the expression of NADPH oxidase 4 (NOX4) can enhance immunogenic cell death (ICD) and promote dendritic cell maturation for tumor‐specific immune response. Furthermore, the EGFR downregulation further mitigated the risk of metastasis and recurrence. In conclusion, BE‐TEL's superior penetration ability together with its combined PDT and EGFR targeted approach paves the way for an efficient strategy against EGFR‐overexpressed CSCC.

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Skin drug delivery using lipid vesicles: A starting guideline for their development

Cited by 51 publications

References 422 publications

Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects

Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects

Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review

Transethosome‐Based Topical Administration Systems with Enhanced Penetration and Dual Actions for Treating EGFR‐Overexpressed Cutaneous Squamous Cell Carcinoma

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