Skin epigenetics

Abstract

The study of skin epigenetics is essential in understanding the mechanisms involved in cutaneous development, homeostasis and disease, and holds great promise for the identification of new therapeutic approaches to both common and rare diseases of the skin.In the current issue of Experimental Dermatology, we highlight this critically important area of research and the most exciting findings by providing a collection of state-of-the-art research articles and critical reviews of the recent literature.

Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners

“…Epigenetic modifications, which include changes in DNA methylation, histone alterations, and the expression of non-coding RNAs, are recognized as crucial mechanisms in regulating gene expression during skin aging [ 33 ]. While these epigenetic shifts do not alter the DNA sequence itself, they can lead to the activation or repression of specific genes by influencing the transcription process, which is the first step in gene expression [ 34 ]. This regulation can alter the levels of messenger RNA produced, which are then translated into polypeptide chains during protein synthesis [ 33 ].…”

“…This regulation can alter the levels of messenger RNA produced, which are then translated into polypeptide chains during protein synthesis [ 33 ]. Epigenetic skincare is an emerging field that focuses on developing topical ingredients that can alter gene expression for skin enhancement [ 34 ]. One such ingredient is equol, an isoflavone derived from the soy isoflavone daidzein by gut bacteria [ 35 ].…”

“…These compounds exert their effects by decreasing the activity of DNA methyltransferase 1 (DNMT1), the most abundant enzyme involved in DNA methylation. By inhibiting DNMT1, these actives can increase the expression of procollagen, a key protein involved in maintaining skin elasticity and strength [ 34 , 39 ].…”

Molecular chaos under the skin: Epigenetic reprogramming in hidradenitis suppurativa

“…Epigenetic mechanisms regulate gene transcription without changing the DNA sequence. So far, studies linking epigenetic mechanisms with skin inflammatory diseases ( 17 ) are mostly limited to atopic dermatitis and psoriasis ( 18 , 19 ). A recent report linked epigenetic age acceleration with extrinsic immune-related changes in patients with HS ( 20 ).…”