Skin Grafting, Cryopreservation, and Diseases: A Review Article

Abstract

Food supplements may be consumed through diet and have been shown to modify skin functions, making them helpful in the management of skin aging. However, there are not many clinical trials that back up these assertions. The stratum corneum, which acts as the organism's contact with its environment, is the principal function of the epidermis of land vertebrates. Antioxidants are chemicals that slow down or prevent other molecules from oxidizing. In people's diets, their use has considerably expanded in recent years. Due to their benefits for health, nutrition, and therapy, natural antioxidants are increasingly being used in place of synthetic antioxidant components. A popular component thought to be an antioxidant is hydrolyzed collagen. With aging comes a steady loss of physiological integrity, capacity to handle stress from the inside out, and function. This is a byproduct of several intricate biological processes that are affected by diseases both local and systemic as well as constitutive and environmental variables. Systemic and constitutive (genetic) variables influence skin aging and its phenotypic manifestation. The biological process of skin aging is complicated and impacted by both external and endogenous causes. The primary contributor to skin cancer is sun exposure. Ultraviolet radiation from the sun can kill skin cells by directly absorbing DNA damage. The skin's hydration is a crucial factor that affects its mechanical and physical characteristics. This study looks at how the stratum corneum's molecular and macroscopic characteristics interact and change with skin wetness. Although there is little information written about them and even less is understood about them, moisturizers are a crucial component of a dermatologist's toolkit. There is a plethora of anticipated skin products on the market, but their true scientific function is yet unknown. These items play a well-known part in many skin problems, while occasionally being dismissed as simple cosmetics.

Electrospun Nanofiber Scaffold for Skin Tissue Engineering: A Review

“…130,131 Nevertheless, autologous grafts face a scarcity of skin sources, while allogeneic grafts are susceptible to immune rejections, thereby limiting their clinical application. 131,132 Silk scaffolds produced through electrostatic spinning exhibit high porosity and excellent pore connectivity, which are favorable for sustaining blood flow and facilitating oxygen exchange in traumatic injuries. Additionally, they effectively hinder the loss of moisture and proteins from wounds.…”

“…Skin grafting remains a prevalent clinical intervention for addressing extensive skin defects, involving the use of autologous or allogeneic skin grafts to facilitate healing and regeneration of the affected skin area. , Nevertheless, autologous grafts face a scarcity of skin sources, while allogeneic grafts are susceptible to immune rejections, thereby limiting their clinical application. , Silk scaffolds produced through electrostatic spinning exhibit high porosity and excellent pore connectivity, which are favorable for sustaining blood flow and facilitating oxygen exchange in traumatic injuries. Additionally, they effectively hinder the loss of moisture and proteins from wounds. , Certain cell regulatory factors and living cells have been incorporated into scaffolds to facilitate cell growth, proliferation, and migration within them, thereby enhancing the rate of formation (Figure ).…”

Cryopreservation: A Review Article

“…However, little is known about the functional and histological effects of cryopreservation on allogeneic skin transplants, especially those that overcome hurdles caused by mismatched histocompatibility. Therefore, cryopreservation of the skin is important in skin grafting [ 36 ].…”