Skin Hydrating Effects of &amp;lt;i&amp;gt;Corchorus olitorius&amp;lt;/i&amp;gt; Extract in a Mouse Model of Atopic Dermatitis

Yokoyama, S.; Hiramoto, Keiichi; Fujikawa, Takahiko; Kondo, Hiroya; Konishi, Nobuyuki; Sudo, Shu; Iwashima, Makoto; Ooi, Kazuya

doi:10.4236/jcdsa.2014.41001

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…Our previous study showed that the COEE cream increased the skin hydration and reduced the TEWL on the AD-like skin lesions in NC/Nga mice, and protected the skin barrier function in these mice. Further, the COEE cream improved the AD symptoms, and suppressed the increases in the AD score in NC/Nga mice [10]. We hypothesized that COEE might be effective against AD.…”

Section: Introductionmentioning

confidence: 94%

Topical application of Corchorus olitorius leaf extract ameliorates atopic dermatitis in NC/Nga mice

Yokoyama¹,

Hiramoto²,

Fujikawa³

et al. 2014

Dermatol Aspects

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Background: Corchorus olitorius leaves are rich in antioxidants, fatty acids, minerals, vitamins and mucilaginous polysaccharides, and have been used as traditional folk medicine. In a previous study, we found that Corchorus olitorius extract reduced transepidermal water loss, and increased skin hydration in atopic dermatitis (AD)-like lesions in NC/Nga mice. The aim of this study was to investigate the effects of topical application of Corchorus olitorius leaf Extract Excluding the high molecular weight compounds (COEE), on atopic dermatitis (AD), and to elucidate the mechanism underlying the ameliorating effect of COEE on AD-like skin lesions. Methods: NC/Nga mice housed under specific pathogen-free (SPF) and conventional conditions were each divided into three groups (control, COEE, base cream). At the start of the experiment, the AD scores on the rostral skin of SPF mice and conventional mice were 0 and 8, respectively. We prepared the COEE cream, and applied it on the rostral skin in NC/Nga mice, and then performed a macroscopic evaluation, an enzyme-linked immunosorbent assay to analyze the plasma levels of immunoglobulin E (IgE) and histamine and immunohistochemical staining for tryptase, matrix metalloproteinase-9 (MMP-9) and collagen type IV. Results: After 14 days of treatment with the COEE cream under conventional conditions, the AD scores and plasma IgE concentrations in the COEE group were significantly lower than those in the other groups. Compared to the control and BC groups, the expression levels of tryptase and MMP-9 were lower, and the degradation of collagen type IV at the basement membrane area was not observed in the COEE group by immunohistochemistry. The mice housed under the SPF conditions were not affected by the test creams. Conclusions: Our results indicate that COEE may therefore be a useful therapeutic candidate for AD due to its suppression of the plasma IgE level and degranulation of mast cells.

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Section: Introductionmentioning

confidence: 94%

Topical application of Corchorus olitorius leaf extract ameliorates atopic dermatitis in NC/Nga mice

Yokoyama¹,

Hiramoto²,

Fujikawa³

et al. 2014

Dermatol Aspects

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“…Wound healing is the process by which the skin and other soft tissues are repaired following injury. Authors Yokoyama et al (2014) investigated the skin hydration on atopic dermatitis in mice using C. olitorius leaf extract excluding high MW (COEW), and the results show a possible therapeutic benefit for atopic dermatitis due to decreased plasma immunoglobulin E (IgE) level as well as mast cell degranulation [ 145 ]. In this study, mice treated with the COEW cream experienced significantly increased skin hydration and reduced transepidermal water loss (TEWL) compared with control mice, but IgE concentrations were not affected, whereas NC/Nga mice showed a decreased AD score.…”

Section: Biological Activitymentioning

confidence: 99%

A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

et al. 2022

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Plant bioactive compounds have gained global significance in terms of both medicinal and economic ramifications due to being easily accessible and are believed to be effective with fewer side effects. Growing relevant clinical and scientific evidence has become an important criterion for accepting traditional health claims of medicinal plants and also supports the traditional uses of Corchorus as folk medicine. C. capsularis and C. olitorius have broad applications ranging from textile to biocomposite, and young leaves and shoots are used as healthy vegetables and have long been used as traditional remedies for fever, ascites, algesia, liver disorders, piles, and tumors in many cultures. This review systematically summarized and emphasized the nutritional attributes, mostly available bioactive compounds, and biological and potential pharmaceutical properties of C. capsularis and C. olitorius, disclosed to users and non-users. Results suggest that various phytochemicals such as cardiac glycosides, phenols, flavonoids, sterols, lipids, and fatty acids were found or analytically identified in different plant parts (leaf, stem, seed, and root), and many of them are responsible for pharmacological properties and their antitumor, anticancer, antioxidant, antinociceptive, anti-inflammatory, analgesic, antipyretic, antiviral, antibacterial, anticonvulsant, antidiabetic and antiobesity, and cardiovascular properties help to prevent and cure many chronic diseases. In addition to their use in traditional food and medicine, their leaves have also been developed for skin care products, and some other possible uses are described. From this review, it is clear that the isolated compounds of both species have great potential to prevent and treat various diseases and be used as functional foods. In conclusion, this comprehensive review establishes a significant reference base for future research into various medical and functional food applications.

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“…This concluded that the plant may maintain the hydration of the skin and inhibit the disturbance of skin barrier function, therefore, it could be used as a complementary therapy in atopic dermatitis. 44 An atopic dermatitis mouse model was used to assess the skin hydration capacity of C. olitorius extract. The extract was combined with a stable base cream and applied to the mice's dorsal skin.…”

Section: Wound Healing Propertymentioning

confidence: 99%

Section: Pharmacological Biodiversitymentioning

confidence: 99%

Pharmacological and phytochemical biodiversity of Corchorus olitorius

et al. 2022

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Skin Hydrating Effects of <i>Corchorus olitorius</i> Extract in a Mouse Model of Atopic Dermatitis

Cited by 6 publications

References 27 publications

Topical application of Corchorus olitorius leaf extract ameliorates atopic dermatitis in NC/Nga mice

Topical application of Corchorus olitorius leaf extract ameliorates atopic dermatitis in NC/Nga mice

A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

Pharmacological and phytochemical biodiversity of Corchorus olitorius

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