Skin-identical Lipids Versus Petrolatum in the Treatment of Tape-stripped and Detergent-perturbed Human Skin

Lodén, Marie; Bárány, Ebba

doi:10.1080/000155500300012774

Cited by 58 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although more comparative clinical trials are needed, several studies suggest that pure petrolatum and lipid-containing creams are equally effective in repairing the skin barrier after experimental perturbation and in the setting of chronic dermatitis. 8, 9 Emollients rich in ceramides have also been shown to be effective in blocking TEWL and improving clinical disease scores. 10 …”

Section: Moisturizers Emollients and Barrier Protection (Table 1)mentioning

confidence: 99%

Topical Therapies for Pruritus

Elmariah¹,

Lerner²

2011

Seminars in Cutaneous Medicine and Surgery

View full text Add to dashboard Cite

Itch, or pruritus, is the predominant symptom associated with acute and chronic cutaneous disease and in some cases, may be debilitating. To date, there is no single universally effective anti-itch treatment. As the pathophysiology of itch in most cutaneous or systemic disorders remains unclear, anti-pruritic therapy is often directed against a variety of targets, including the epidermal barrier, immune system, or the nervous system. Topical therapy is the mainstay of dermatologic management of acute or localized itch or in patients with contraindications to systemic therapies. This review will summarize current topical therapies to treat pruritus and discuss potential future therapies.

show abstract

Section: Moisturizers Emollients and Barrier Protection (Table 1)mentioning

confidence: 99%

Topical Therapies for Pruritus

Elmariah¹,

Lerner²

2011

Seminars in Cutaneous Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…These studies were mostly conducted on detergent- or tape-stripped-perturbed human skin and/or hairless mouse skin [14,113] or on skin with diet-induced AD-like symptoms in animal models [114,115]. The skin barrier function is commonly measured by the TEWL value which is a marker for the inside-outside barrier.…”

Section: Effect Of Oral Phytocer-based Dietary Supplements On Skin Bamentioning

confidence: 99%

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Tessema

Gebre‐Mariam

Neubert

et al. 2017

Skin Pharmacol Physiol

View full text Add to dashboard Cite

The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated. Recently, however, the barrier function improving effect of plant-derived CERs has attracted much attention. Phyto-derived CERs (phytoCERs) are preferable due to their assumed higher safety as they are mostly isolated from dietary sources. The beneficial effects of phytoCER-based oral dietary supplements for skin hydration and skin barrier reinforcement have been indicated in several studies involving animal models as well as human subjects. Ingestible dietary supplements containing phytoCERs are also widely available on the market. Nonetheless, little effort has been made to investigate the potential cosmetic applications of topically administered phytoCERs. Therefore, summarizing the foregoing investigations and identifying the gap in the scientific data on plant-derived CERs intended for skin-health benefits are of paramount importance. In this review, an attempt is made to synthesize the information available in the literature regarding the effects of phytoCER-based oral dietary supplements on skin hydration and barrier function with the underlying mechanisms.

show abstract

“…Petrolatum was incorporated in the pharmaceutical and skincare industry firstly as a vehicle and nowadays as an effective moisturizer ingredient. This mixture of hydrocarbons creates an oily barrier over the skin surface, reducing TEWL both in healthy [98] and irritated human skin [99,100]. Due to its occlusive properties, petrolatum derivatives can retain water, consequently restoring the skin barrier.…”

Section: Petrolatum Derivativesmentioning

confidence: 99%

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

et al. 2023

View full text Add to dashboard Cite

Skin repair encompasses epidermal barrier repair and wound healing which involves multiple cellular and molecular stages. Therefore, many skin repair strategies have been proposed. In order to characterize the usage frequency of skin repair ingredients in cosmetics, medicines, and medical devices, commercialized in Portuguese pharmacies and parapharmacies, a comprehensive analysis of the products’ composition was performed. A total of 120 cosmetic products, collected from national pharmacies online platforms, 21 topical medicines, and 46 medical devices, collected from INFARMED database, were included in the study, revealing the top 10 most used skin repair ingredients in these categories. A critical review regarding the effectiveness of the top ingredients was performed and an in-depth analysis focused on the top three skin repair ingredients pursued. Results demonstrated that top three most used cosmetic ingredients were metal salts and oxides (78.3%), vitamin E and its derivatives (54.2%), and Centella asiatica (L.) Urb. extract and actives (35.8%). Regarding medicines, metal salts and oxides were also the most used (47.4%) followed by vitamin B5 and derivatives (23.8%), and vitamin A and derivatives (26.3%). Silicones and derivatives were the most common skin repair ingredients in medical devices (33%), followed by petrolatum and derivatives (22%) and alginate (15%). This work provides an overview of the most used skin repair ingredients, highlighting their different mechanisms of action, aiming to provide an up-to-date tool to support health professionals’ decisions.

show abstract

Skin-identical Lipids Versus Petrolatum in the Treatment of Tape-stripped and Detergent-perturbed Human Skin

Cited by 58 publications

References 13 publications

Topical Therapies for Pruritus

Topical Therapies for Pruritus

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

Contact Info

Product

Resources

About