Skin Infections Caused by Emerging Candida Species

Espinosa-Hernández, Víctor Manuel; Morales-Pineda, Verónica; Martínez‐Herrera, Erick

doi:10.1007/s12281-020-00380-9

Cited by 13 publications

(8 citation statements)

References 30 publications

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“…For fungi, the herbs were most active against C. parapsilosis (49%), which increasingly causes infections since the turn of the century: fungemia, endocarditis, meningitis, skin infections, etc. [ 57 – 59 ]. HTMs also showed some inhibition of Saccharomyces cerevisiae (31%), C. albicans (26%), C. auris (24%), and C. glabrata (13%).…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical study of Hakka traditional medicine in Ganzhou, China and their antibacterial, antifungal, and cytotoxic assessments

Yang

Aissa

et al. 2022

BMC Complement Med Ther

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Background Traditional herbs played a crucial role in the health care of the Hakka people. However, studies to identify these traditional herbs are few. Here we document and assess the potential of these plants for treating microbial infections. Many herbs used by the Hakka people could potentially be a novel medicinal resource. Methods Local herb markets were surveyed via semi-structured interviews, complemented by direct observations to obtain information on herbal usage. For each herb selected for this study, extracts in four different solvents were prepared, and tested for activity against 20 microorganisms, as well as cancerous and noncancerous cells. All data were subjected to cluster analysis to discover relationships among herbs, plant types, administration forms, solvents, microorganisms, cells, etc., with the aim to discern promising herbs for medicine. Results Ninety-seven Hakka herbs in Ganzhou were documented from 93 plants in 62 families; most are used for bathing (97%), or as food, such as tea (32%), soup (12%), etc. Compared with the Chinese Pharmacopoeia and Chinese Materia Medica, 24 Hakka medicines use different plant parts, and 5 plants are recorded here for the first time as traditional medicines. The plant parts used were closely related with the life cycle: annual and perennial herbs were normally used as a whole plant, and woody plants as (tender) stem and leaf, indicating a trend to use the parts that are easily collected. Encouragingly, 311 extracts (94%) were active against one or more microorganisms. Most herbs were active against Gram-positive bacteria, such as Staphylococcus aureus (67%), Listeria innocua (64%), etc. Cytotoxicity was often observed against a tumor cell, but rarely against normal cells. Considering both antimicrobial activity and cytotoxicity, many herbs reported in this study show promise as medicine. Conclusion Hakka people commonly use easily-collected plant parts (aerial parts or entire herb) as medicine. External use of decoctions dominated, and may help combating microbial infections. The results offer promising perspectives for further research since little phytopharmacology and phytochemistry has been published to date. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Ethnobotanical study of Hakka traditional medicine in Ganzhou, China and their antibacterial, antifungal, and cytotoxic assessments

Yang

Aissa

et al. 2022

BMC Complement Med Ther

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“…Although several studies have investigated the positive rate of non-albicans Candida spp., none have exclusively examined C. albicans [ 23 ]. Therefore, more detailed research on the latter is warranted.…”

Section: Discussionmentioning

confidence: 99%

Distribution Analysis ofCandida albicansaccording to Sex and Age in Clinical Specimen Testing for Sexually Transmitted Diseases

Choi

Jeon

Kim

2022

J. Microbiol. Biotechnol.

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The prevalence of candidiasis, a contagious disease with high morbidity and mortality, has sharply increased globally over the last two decades. Candida albicans can cause serious infections in patients with weak immunity and in recipients of prolonged antibiotic treatment. Consequently, rapid and accurate identification of species can play an important role in the treatment of candidiasis. Here, we investigated the positive rate and infection trend of C. albicans according to age, specimen type, and sex using multiplex real-time polymerase chain reaction-based testing of samples collected for the diagnosis of sexually transmitted diseases in Korea between 2018 and 2020. When the type of specimen collected was a swab, the positive rate of C. albicans was higher among younger women, and tended to decrease with age. Analysis of swab samples revealed higher positive rates than urinalysis. The reduction trend in positive rates by age was comparable between the overall samples and urine specimens. Among male patients, the positive rate did not differ substantially across the various types of specimens collected. Previous studies have shown a higher prevalence of non-albicans Candida species than C. albicans in clinical specimens, and exclusion of the former from our analysis may be a limitation of this study. However, our findings contribute significantly to the literature because globally, there is a paucity of epidemiological studies using molecular techniques to detect C. albicans in sexually transmitted disease test samples.

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“…These organisms can invade the bloodstream and result in invasive candidiasis (Spampinato and Leonardi 2013 ; Tóth et al 2018 ). Recently, C. africana , C. duobushaemulonii , and especially C. auris were classified as emerging pathogens that are difficult to treat because of their drug resistance (Černáková et al 2021 ; Espinosa-Hernández et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Fungal coexistence in the skin mycobiome: a study involving Malassezia, Candida, and Rhodotorula

Naik,

Sasikumar,

et al. 2024

AMB Expr

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Evidence of fungal coexistence in humans points towards fungal adaptation to the host environment, like the skin. The human commensal Malassezia has evolved, especially residing in sebum-rich areas of the mammalian body where it can get the necessary nutrition for its survival. This fungus is primarily responsible for skin diseases like Pityriasis versicolor (PV), characterized by hypo or hyperpigmented skin discoloration and erythematous macules. In this manuscript, we report a 19-year-old healthy female who presented with a one-year history of reddish, hypopigmented, asymptomatic lesions over the chest and a raised erythematous lesion over the face. Upon clinical observation, the patient displayed multiple erythematous macules and erythematous papules over the bilateral malar area of the face, along with multiple hypopigmented scaly macules present on the chest and back. Based on the above clinical findings, a diagnosis of PV and Acne vulgaris (AV) was made. Interestingly, the patient was immunocompetent and didn’t have any comorbidities. Upon isolation of skin scrapings and post-culturing, we found the existence of three fungal genera in the same region of the patient’s body. We further went on to confirm the identity of the particular species and found it to represent Malassezia, Rhodotorula, and Candida. We report how Malassezia, the predominant microbial resident skin fungus, coexists with other fungal members of the skin mycobiome. This study on an applied aspect of microbiology also shows how important it is to identify the fungal organism associated with skin infections so that appropriate therapeutics can be advised to avoid cases of relapse.

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Skin Infections Caused by Emerging Candida Species

Cited by 13 publications

References 30 publications

Ethnobotanical study of Hakka traditional medicine in Ganzhou, China and their antibacterial, antifungal, and cytotoxic assessments

Ethnobotanical study of Hakka traditional medicine in Ganzhou, China and their antibacterial, antifungal, and cytotoxic assessments

Distribution Analysis ofCandida albicansaccording to Sex and Age in Clinical Specimen Testing for Sexually Transmitted Diseases

Fungal coexistence in the skin mycobiome: a study involving Malassezia, Candida, and Rhodotorula

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