Skin Infections

Prieto-Granada, Carlos; Lobo, Alice Z.C.; Mihm, Martín C.

doi:10.1016/b978-1-4160-3429-2.00019-5

Cited by 17 publications

(18 citation statements)

References 961 publications

(1,341 reference statements)

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“…El tratamiento de elección para tratar la botriomicosis depende del tipo de bacteria que se identifique y puede ir desde un manejo médico hasta uno radical como una lobectomía. Nuestra paciente, a la que se le detectaron bacterias gramnegativas como la Escherichia coli, pudo haber sido medicada con ceftriaxona (1 a 2 g una vez al día), ciprofloxacino (400 mg IV cada 12 horas), imipenem (500 mg IV cada 6 horas), o ertapenem (1 mg IV cada 24 horas) [12] .…”

Section: Discussionunclassified

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Paciente con botriomicosis pulmonar primaria confundida con actinomicosis: una mortal e infrecuente enfermedad infecciosa

Nakandakari

Rosa

Gutiérrez³

et al. 2019

Acta Med Peru

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La botriomicosis es una mortal e infrecuente infección bacteriana granulomatosa supurativa. Presentamos el caso de una paciente de 52 años que reingresó por cuadro respiratorio complicado dos meses anteriores, con síntomas caracterizados por tos, disnea, alza térmica, inapetencia y pérdida de peso. En la tomografía pulmonar se observó fibrosis, infiltrado alveolar bilateral, cavidades y bronquiectasias bilaterales. La citología de aspirado bronquial mostró gránulos azurófilos haciendo sospechar de actinomicosis, por lo que se le dio tratamiento con penicilina, sin mejoría. En el segundo cultivo de aspirado bronquial el patólogo describió a dos grupos de colonias bacterianas gramnegativas de Escherichia coli, las cuales simularon gránulos azurófilos, planteándose como diagnóstico definitivo botriomicosis pulmonar por E. coli BLEE, no obstante, la paciente ya había fallecido. Como conclusión, se reporta una patología infecciosa de muy baja prevalencia, pero frecuentemente confundida con la Actinomicosis, cuyo diagnóstico temprano es extremadamente importante para reducir su alta mortalidad.

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Section: Discussionunclassified

“…No obstante, la Escherichia coli detectada era productora de BLEE, enzimas capaces de hidrolizar a las penicilinas, cefalosporinas (menos las cefamicinas) y los monobactámicos (12) ; por lo cual, quedaban como alternativas la asociación de cefalosporinas con ácido clavulánico, sulbactam, tazobactam, imipenem o ertapenem.…”

Section: Discussionunclassified

Paciente con botriomicosis pulmonar primaria confundida con actinomicosis: una mortal e infrecuente enfermedad infecciosa

Nakandakari

Rosa

Gutiérrez³

et al. 2019

Acta Med Peru

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“…ACL comprises a spectrum of clinical manifestations. The variability in clinical presentation and outcome is related to multiple parameters, including immune status of the host and the infecting species . For example, infection with Old World species (such as L. major and L. tropica ) typically manifests with self‐limiting cutaneous disease alone, while infection by New World species (such as L. braziliensis ) tends to be associated with a broader spectrum of disease ranging from localized but chronic cutaneous disease to severe mucosal involvement, as well as chronically evolving lesions consistent with a diagnosis of ICL …”

Section: Clinical Presentationmentioning

confidence: 99%

“…With progressive disease, particularly at mucosal sites, erosion of subjacent osseocartilaginous structures may be evident . For all subtypes of disease, the histochemical stain most effective in highlighting the amastigote forms is the Giemsa stain . Although most readily identifiable in wet preparations, a key protozoal structure, which may aid in establishing the diagnosis, is presence of a paranuclear rod‐shaped kinetoplast (Fig.…”

Section: Diagnosismentioning

confidence: 99%

Intermediate/borderline disseminated cutaneous leishmaniasis

et al. 2012

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Leishmaniasis is a diverse group of vector-borne diseases caused by a subset of predominantly intracellular protozoal species of the genus Leishmania. Cutaneous disease may be subdivided into localized, intermediate, and diffuse forms. Intermediate cutaneous leishmaniasis is distributed widely in Latin America and is characterized by cutaneous lesions, which may be accompanied by mucosal disease and demonstrate a tendency toward chronicity and relapse as well as resistance to standard treatment regimens. Leishmania parasites of the subgenus Viannia have been identified as the major etiologic agent of this subset of infections. The present review provides a brief perspective on leishmaniasis followed by a review of classification, transmission, clinical presentation, and evolution of disease, immunology, and current treatment approaches for the intermediate/borderline disseminated subset of cutaneous leishmaniasis.

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“…Leishmania species such as Leishmania donovani, Leishmania infantum, and Leishmania chagasi are the main organisms responsible for VL. Leishmania donovani has been found to be mostly affecting children as well as adults, whereas other two species are able to affect only children (Prieto-Granada, Lobo, & Mihm, 2010).…”

mentioning

confidence: 99%

An integrative approach using systems biology, mutational analysis with molecular dynamics simulation to challenge the functionality of a target protein

Bora

Jha

2019

Chem Biol Drug Des

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Visceral leishmaniasis affects millions of people worldwide in areas where Leishmania donovani is endemic. The protozoan species serves a greater threat as it has gradually evolved drug resistance whereby requiring newer approaches to treat the infection. State‐of‐art techniques are mostly directed toward finding better targets extracted from the available proteome data. In light of recent computational advancements, we ascertain and validate one such target, adenylosuccinate lyase (ADSL) by implementation of in‐silico methods which led to the identification of critical amino acid residues that affects its functional attributes. Our target selection was based on comprehensive topological analysis of a knowledge‐based protein–protein interaction network. Subsequently, mutations were incorporated and the dynamic behavior of mutated and native proteins was traced using MD simulations for a total time span of 600 ns. Comparative analysis of the native and mutated structures exhibited perceptible changes in the ligand‐bound catalytic region with respect to time. The unfavorable changes in the orientations of specific catalytic residues, His118 and His196, induced by generated mutations reduce the enzyme specificity. In summary, this integrative approach is able to select a target against pathogen, identify crucial residues, and challenge its functionality through the selected mutations.

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Skin Infections

Cited by 17 publications

References 961 publications

Paciente con botriomicosis pulmonar primaria confundida con actinomicosis: una mortal e infrecuente enfermedad infecciosa

Paciente con botriomicosis pulmonar primaria confundida con actinomicosis: una mortal e infrecuente enfermedad infecciosa

Intermediate/borderline disseminated cutaneous leishmaniasis

An integrative approach using systems biology, mutational analysis with molecular dynamics simulation to challenge the functionality of a target protein

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