Skin lesions and neutrophilic leukemoid reaction in a patient with angioimmunoblastic T‐cell lymphoma: a case report and review of the literature

He, Jia; Liang, Houjie

doi:10.1002/ccr3.273

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Glucocorticoids remain one of the most effective and most commonly used drugs to kill lymphoma cells. The role and mechanism of glucocorticoids-GR in lymphoma has been well studied [ 1 – 2 , 6 , 8 ]. It seemed that colon cancer cell line LoVo and lymphoma cell line Jurkat shared the mechanism, glucocorticoids regulating GR to suppress NF-κB activity [ 2 , 6 ].…”

Section: Resultsmentioning

confidence: 99%

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Dexamethasone affects cell growth/apoptosis/chemosensitivity of colon cancer via glucocorticoid receptor α/NF-κB

Zhou

Yang

et al. 2017

Oncotarget

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Glucocorticoids are effective to treat lymphoma and leukemia. Their effect in colon cancer remains far from clear. Here, we found that glucocorticoid receptor (GR) α protein level was dramatically lower in colon cancer than in lymphoma. Colon cell lines LoVo and HCT116 were GRα-rich and GRα was not detectable in HT29 or SW480. Dexamethasone significantly inhibited cell growth of GRα-rich cell lines and did not significantly affect GRα-negative cell lines. Dexamethasone induced apoptosis and increased chemosensitivity of GRα-rich cell lines. Knockdown of GRα significantly attenuated dexamethasone effects on cell growth, apoptosis and chemosensitivity. NF-κB p65 significantly correlated with GRα in colon cancer samples. Dexamethasone decreased NF-κB p65 activity. Knockdown of NF-κB p65 increased apoptosis. Our data demonstrate GRα protein level is dramatically lower in colon cancer than in lymphoma. Dexamethasone inhibits cell growth, induces apoptosis and enhances chemosensitivity in colon cancer, at least partly, via GRα and NF-κB.

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Section: Resultsmentioning

confidence: 99%

“…Glucocorticoids have unique property to cause massive cell death and cell cycle arrest in malignant cells from the lymphoid lineage [ 1 – 2 ]. But they are generally not as effective in the treatment of non-hematological cancers [ 2 – 4 ].…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone affects cell growth/apoptosis/chemosensitivity of colon cancer via glucocorticoid receptor α/NF-κB

Zhou

Yang

et al. 2017

Oncotarget

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“…Hyperleukocytosis with neutrophilia has been reported once in AITL in a single case report whereby, the patient presented with vesicular rash and hypergranulopoiesis of the bone marrow (2). The presence of rash, hyperleukocytosis and neutrophilia with the absence of circulating abnormal lymphoid cells in the peripheral blood film may divert the diagnosis to leukemoid reaction or Myeloproliferative neoplasm, as the bone marrow aspirate, and trephine was done prior to a lymph node biopsy due to the misleading haematological changes.…”

Section: Discussionmentioning

confidence: 97%

Angioimmunoblastic T-cell Lymphoma Presenting With a Neutrophilic Leukemoid Reaction: A Diagnostic Challenge

Muthu Krishnan,

Caroline,

Seman

2023

MJMHS

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Angioimmunoblastic T-cell lymphoma (AITL) accounts for 1-2% of all non-Hodgkins lymphoma. Patients present with lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinemia and skin lesions. The presence of rash and neutrophilia in the absence of circulating abnormal lymphocytes in the peripheral blood film leads to a misdiagnosis. A 33-year-old presented with cervical lymphadenopathy with WCC of 104.9 g/dl, maculopapular rash, loss of weight and appetite associated with B symptoms. His peripheral blood film revealed hyperleukocytosis with a neutrophilic leukemoid reaction. Neutrophil alkaline phosphatase (NAP) score was high. Bone marrow aspirate and trephine were suggestive of neutrophilic leukemoid reaction with features of granulocytic hyperplasia with no lymphoid aggregates suggestive of neutrophilic leukemoid reaction secondary to underlying malignancy with a differential of myeloproliferative neoplasm if no reactive causes of granulocytic hyperplasia could be found. A lymph node biopsy was done later and was consistent with AITL. This case illustrates the rare presentation of AITL with a neutrophilic leukemoid reaction in the absence of anaemia, eosinophilia and abnormal lymphoid cells.

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Quantitative changes in blood cells

2021

Blood Cells

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Skin lesions and neutrophilic leukemoid reaction in a patient with angioimmunoblastic T‐cell lymphoma: a case report and review of the literature

Cited by 5 publications

References 37 publications

Dexamethasone affects cell growth/apoptosis/chemosensitivity of colon cancer via glucocorticoid receptor α/NF-κB

Dexamethasone affects cell growth/apoptosis/chemosensitivity of colon cancer via glucocorticoid receptor α/NF-κB

Angioimmunoblastic T-cell Lymphoma Presenting With a Neutrophilic Leukemoid Reaction: A Diagnostic Challenge

Quantitative changes in blood cells

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