Skin lesions in plasmacytoid dendritic cell leukaemia

Blastic Plasmacytoid Dendritic Cell Neoplasm

“…4 BPDCN affects primarily the elderly and has an aggressive clinical course with a poor prognosis. [5][6][7] Ninety percent of cases presented with asymptomatic solitary/multifocal cutaneous reddish-brown nodules or bruise-like lesions. 5,6 Bone marrow was involved in most cases, however, any organ, can be affected.…”

“…[5][6][7] Ninety percent of cases presented with asymptomatic solitary/multifocal cutaneous reddish-brown nodules or bruise-like lesions. 5,6 Bone marrow was involved in most cases, however, any organ, can be affected. Extramedullary leukemic infiltration may precede acute myeloid leukemia.…”

A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm

“…The clinical presentation is quite constant, with 90% of patients presenting with asymptomatic solitary/multifocal cutaneous reddish-brown nodules or bruise-like lesions4,5. Bone marrow is involved in most cases, and practically any organ can be affected.…”

“…Bone marrow is involved in most cases, and practically any organ can be affected. The disease follows a short course and fulminant leukemia is the common terminal stage4-6. The diagnosis relies on the immunophenotypic features of the malignant cells.…”

“…FCM is preferred over immunohistochemical analysis since it allows for the examination of more markers and their intensity determination7,8. The expression of CD4, CD56, and CD123 in the absence of T-cell, B-cell, or myeloid markers defines BPDCN4-8. The correct diagnosis implies an appropriate panel of antibodies; in contrast, insufficient knowledge on this entity and inadequate immunophenotypic investigation can lead to the misdiagnosis of a different leukemia8.…”