Skin Manifestations in Solid Organ Transplant Recipients

Tsambaos, D.; Badavanis, George

doi:10.1159/000056364

Cited by 7 publications

(14 citation statements)

References 51 publications

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“…The prevalence of skin infections in OTR is very high . The spectrum of skin infections seems to vary according to the time posttransplant …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The occurrence of malignancies increases after organ transplantation, and skin cancers are the most prevalent . The odds of developing skin cancer rise with increasing time after transplantation . These cancers include squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Kaposi sarcoma (SK), Merkel cell carcinoma (MCC), and malignant melanoma (MM) …”

Section: Introductionmentioning

confidence: 99%

“…The inflammatory cutaneous conditions such as gingival hyperplasia, acne, and seborrheic dermatitis are common at any time after the transplant and might be strongly associated with the type of the immunosuppressive drugs employed …”

Section: Introductionmentioning

confidence: 99%

“…Several factors are considered to predict cutaneous complications in OTR, mainly long‐term immunosuppressive regimen, gender, skin phototype, age at transplantation, the role of potential oncogenic viruses, duration and intensity of exposure to ultraviolet (UV) light prior to transplantation, and presence of (pre)‐malignant skin lesions …”

Section: Introductionmentioning

confidence: 99%

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Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients

et al. 2018

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Background Skin lesions are very common among organ transplant recipients (OTR), particularly infections and tumors, because of the immunosuppressive state these patients are put in.Methods 177 OTR were examined. Skin lesions were categorized into neoplastic, infectious, and inflammatory diseases. ResultsThe mean age of OTR was 52 years, the mean age at transplantation was 42.7 years, and kidney was the most common organ transplanted (72%). Skin lesions were found in 147 patients (83%). Cutaneous infections were seen in 106 patients (60%). Warts (30%) had the larger incidence and were associated with azathioprine (P = 0.026), cyclosporine (P = 0.006), and tacrolimus (P = 0.009). Superficial mycoses occurred in 16% of OTR, mostly onychomycosis, which was associated with tacrolimus (P = 0.040). Actinic keratosis (AK) occurred in 31% of patients and cutaneous tumors in 56%. Squamous cell carcinoma (SCC) was the most common tumor type affecting 36% of OTR (n = 64), with invasive SCC predominating over in situ SCC, whereas basal cell carcinoma (BCC) accounted for 17%. Both SCC and BCC were more numerous in patients' skin type I (P < 0.05). SCC was more frequent (36%) in combined kidney and liver recipients (P = 0.004), and BCC was associated with cyclosporine (P = 0.047). Inflammatory complications (acne, alopecia, hypertrichosis, and gingival overgrowth) were observed in 17.5% of patients.Conclusions Organ transplant recipients must be regularly evaluated by dermatologists, who should be alert to the onset of infections and skin (pre)malignant diseases in these patients.

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“…The prevalence of skin infections in OTR is very high . The spectrum of skin infections seems to vary according to the time posttransplant …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients

et al. 2018

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Mucosal Candida infection and colonisation as well as associated risk factors in solid organ transplant recipients

Antoniewicz

Relijc

Poitschek

et al. 2009

Eur J Clin Microbiol Infect Dis

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More detailed information on Candida colonisation and infection of the mucous membranes in organ transplant recipients (OTR) is of particular interest. Therefore, this issue was prospectively evaluated in 400 different OTR in different posttransplantation periods as well as in 405 healthy age- and sex-matched controls. In addition, possible risk factors and the clinical condition in the OTR were evaluated. Independent of the transplanted organ there is a statistically significant decrease in the number of positive culture results, of symptomatic candidiasis and an increase of isolated non-albicans Candida species corresponding to length of the posttransplantation period. No significant differences could be observed in the OTR in association with different immunosuppressive regimen; however, higher dosages of corticosteroids and tacrolimus correlated with symptomatic candidiasis. As Candida spp. may also cause systemic infection and dissemination, additional knowledge about cofactors and associated strains may have an impact on therapeutic decisions.

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Skin Disease in Immunosuppressed Hosts

Garzon¹

2007

Comprehensive Pediatric Hospital Medicine

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Skin Manifestations in Solid Organ Transplant Recipients

Cited by 7 publications

References 51 publications

Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients

Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients

Mucosal Candida infection and colonisation as well as associated risk factors in solid organ transplant recipients

Skin Disease in Immunosuppressed Hosts

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