Skin manifestations of adult T‐cell leukemia/lymphoma: Clinical, cytological and immunological features

Tokura, Y.; Sawada, Yu; Shimauchi, Takatoshi

doi:10.1111/1346-8138.12328

Cited by 53 publications

(39 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The evolution to ATLL occurs in 1 to 5% of infected patients, after years (or even decades) of infection 1 . Considered a systemic neoplasm, ATLL manifests in cutaneous ways in about 50% of patients 85 .…”

Section: Cumhuriyet Medical Journalmentioning

confidence: 99%

“…This system divides cases into four subtypes: acute, lymphomatous, chronic, and smoldering 86 . The acute and lymphomatous types have worse prognoses, median survivals of 6.2 and 10.2 months, respectively; the chronic and smoldering types, on the other hand, have better prognoses, with median survivals of 24.3 and 154 months, respectively 85,87 . However, patients with the lymphomatous, chronic, and smoldering types may experience acute crises, which involve high mortality 85 .…”

Section: Figure 5: Sézary Syndrome Erythroderma (Diffuse Erythema Anmentioning

confidence: 99%

“…The acute and lymphomatous types have worse prognoses, median survivals of 6.2 and 10.2 months, respectively; the chronic and smoldering types, on the other hand, have better prognoses, with median survivals of 24.3 and 154 months, respectively 85,87 . However, patients with the lymphomatous, chronic, and smoldering types may experience acute crises, which involve high mortality 85 . The clinical manifestations of ATLL are varied, including papules, plaques, nodules, tumors, ichthyosiform aspects, purpura, and even erythroderma, and the type of skin lesion has an impact on the prognosis.…”

Section: Figure 5: Sézary Syndrome Erythroderma (Diffuse Erythema Anmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous lymphomas: A review

Miyashiro¹,

Sanches²

2015

Cumhuriyet Med J

View full text Add to dashboard Cite

SUMMARYSkin may be affected by non-Hodgkin lymphomas, and it is the second most frequently involved extranodal organ, after the gastrointestinal tract. Cutaneous lymphomas may originate from T, B, or NK lymphocytes. Diagnosis is difficult, and knowledge of these diseases is important to ensure their detection and adequate treatment and follow-up. Clinical picture is heterogeneous, and histology is essential to confirm the diagnosis. The classification is given by the correlation between clinical findings, histology and immunophenotyping. Therapeutic options include skin-directed therapies, immunomodulatory or low-dose immunosuppressive drugs. Rare cases of aggressive disease require systemic multidrug chemotherapy. The purpose of this review is to describe the ontogeny of T, B and NK lymphocytes, and to detail the most accepted classification of cutaneous lymphomas, proposed by the World Health Organisation and European Organisation for Research and Treatment of Cancer. Treatment of cutaneous lymphomas will be briefly discussed.

show abstract

Section: Cumhuriyet Medical Journalmentioning

confidence: 99%

Section: Figure 5: Sézary Syndrome Erythroderma (Diffuse Erythema Anmentioning

confidence: 99%

Section: Figure 5: Sézary Syndrome Erythroderma (Diffuse Erythema Anmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous lymphomas: A review

Miyashiro¹,

Sanches²

2015

Cumhuriyet Med J

View full text Add to dashboard Cite

show abstract

“…Although most patients present with disseminated disease by highly pleomorphic T-cells, ATLL may present similarly to PC-SMTCL as a primary cutaneous, dermal or subcutaneous infiltrate of small-to medium-sized CD4 þ T-cells that form a clinical papule, plaque, or tumor. 7,[56][57][58] Epidermotropism may be limited or absent, 56,58 and histiocytes and admixed granulomas may be prominent. 57 In addition, the T cells in ATLL often lack CD7, 56,58 and they commonly express PD1.…”

Section: -55mentioning

confidence: 99%

Controversies and Considerations in the Diagnosis of Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoma

Lan

Brown

Hristov

2014

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.—Primary cutaneous CD4+ small/medium T-cell lymphoma is a provisional and controversial entity with a broad differential diagnosis. Despite being an uncommon lymphoma, it is a frequent diagnostic consideration in cutaneous biopsies with a dense lymphoid infiltrate because it shows overlapping features with reactive lymphoid hyperplasia (pseudolymphoma) and a variety of other primary cutaneous and systemic lymphomas. However, proper classification of this process is important for determining patient prognosis and treatment options. Objective.—To review the clinical, morphologic, immunophenotypic, and genetic features of primary cutaneous CD4+ small/medium T-cell lymphoma and contrast those features with entities in the differential diagnosis. Data Sources.—Applicable literature will be reviewed with emphasis on current controversies and distinguishing characteristics. Conclusions.—Although many consider primary cutaneous CD4+ small/medium T-cell lymphoma to be indistinguishable from reactive lymphoid hyperplasia/pseudolymphoma, it can be differentiated from other primary cutaneous and systemic lymphomas. Patients with solitary lesions of primary cutaneous CD4+ small/medium T-cell lymphoma generally have an excellent prognosis. Nevertheless, a subset of patients who have been reported to meet criteria for this lymphoma have followed a more-aggressive course; however, those patients show some differing clinical, morphologic, and immunophenotypic features.

show abstract

“…Most cases of ATL belong to HTLV-1-endemic areas in southwestern Japan, Central Africa and the Caribbean Basin [1] [2].…”

Section: Introductionmentioning

confidence: 99%

Two Cases of Tuberculosis Manifesting as Cutaneous Solitary Mass in Patients with Adult T-Cell Leukemia/Lymphoma

Koga¹,

Fujita²,

Imafuku³

2016

JTR

View full text Add to dashboard Cite

Tuberculosis (TB) is a major public health problem worldwide and a large number of fatal cases are still reported. Immunocompetent individuals are naturally susceptible to TB, and immunocompromised patients have a greater risk of infection. Although patients with adult T-cell leukemia/lymphoma (ATL) are in an immunosuppressed condition, there is only one reported case of TB accompanied with ATL in the Englishlanguage literature in the field of dermatology. Here, we report two patients with chronic-type ATL infected with TB manifesting as cutaneous solitary masses. Case 1 was a 58-year-old woman diagnosed with lumbar abscess with pulmonary TB. Case 2 was an 84-year-old woman diagnosed with tuberculous lymphadenitis in the left cervical region. It is important to raise the differential diagnosis of TB and perform tissue culture for acid-fast bacilli as well as Interferon-Gamma release assay test when dermatologists encounter mass lesions in patients with ATL.

show abstract

Skin manifestations of adult T‐cell leukemia/lymphoma: Clinical, cytological and immunological features

Cited by 53 publications

References 44 publications

Cutaneous lymphomas: A review

Cutaneous lymphomas: A review

Controversies and Considerations in the Diagnosis of Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoma

Two Cases of Tuberculosis Manifesting as Cutaneous Solitary Mass in Patients with Adult T-Cell Leukemia/Lymphoma

Contact Info

Product

Resources

About