Skin manifestations of chronic kidney disease

Robles-Méndez, Juan Carlos; Vázquez‐Martínez, Osvaldo; Ocampo‐Candiani, Jorge

doi:10.1016/j.ad.2015.05.007

Cited by 20 publications

(29 citation statements)

References 49 publications

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“…If the disease is still uncontrolled, patients may undergo parathyroidectoy. Studies show that patients who undergo early total or subtotal parathyroidectomy have a longer survival compared to those who do not undergo the procedure . Increased frequency and duration of dialysis with low calcium dialysate controls electrolyte levels and improves this condition .…”

Section: Specificmentioning

confidence: 99%

“…Studies show that patients who undergo early total or subtotal parathyroidectomy have a longer survival compared to those who do not undergo the procedure . Increased frequency and duration of dialysis with low calcium dialysate controls electrolyte levels and improves this condition . Bisphosphonates such as etidronate and pamidronate have been effective, resulting in pain relief within days and resolution of lesions within weeks .…”

Section: Specificmentioning

confidence: 99%

“…Increased frequency and duration of dialysis with low calcium dialysate controls electrolyte levels and improves this condition . Bisphosphonates such as etidronate and pamidronate have been effective, resulting in pain relief within days and resolution of lesions within weeks . Sodium thiosulfate may act by displacing calcium from calcium phosphorus, forming calcium thiosulfate, which is more soluble and can be excreted through haemodialysis or by the kidneys .…”

Section: Specificmentioning

confidence: 99%

“…Bisphosphonates such as etidronate and pamidronate have been effective, resulting in pain relief within days and resolution of lesions within weeks . Sodium thiosulfate may act by displacing calcium from calcium phosphorus, forming calcium thiosulfate, which is more soluble and can be excreted through haemodialysis or by the kidneys . It has achieved pain relief within days and wound healing within 8 weeks .…”

Section: Specificmentioning

confidence: 99%

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Dermatologic manifestations in end stage renal disease

Blaha

Nigwekar

Combs

et al. 2018

Hemodialysis International

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Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. In this article we focus on the cutaneous changes most commonly seen in ESRD patients. PubMed/Medline database search was done for published literature on skin manifestations in ESRD patients. All the available literature was reviewed and relevant articles were used to discuss about clinical features, pathogenesis, histology and treatment of each skin disorder in ESRD patients. Most commonly encountered skin manifestations in patients with ESRD are pruritus, xerosis, pigmentation changes, nail changes, perforating disorders, calcifying disorders, bullous dermatoses and nephrogenic systemic fibrosis. Skin manifestations in ESRD can be difficult to treat and multiple comorbidities in this patient population can exacerbate these disorders. Many of the treatment options are experimental with evidence largely derived from the case reports and small clinical trials. More large‐scale trials are needed to firmly establish evidence based treatment guidelines. Prompt evaluation and management of these disorders improve morbidity and quality of life in ESRD patients.

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Section: Specificmentioning

confidence: 99%

Section: Specificmentioning

confidence: 99%

Section: Specificmentioning

confidence: 99%

Section: Specificmentioning

confidence: 99%

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Dermatologic manifestations in end stage renal disease

Blaha

Nigwekar

Combs

et al. 2018

Hemodialysis International

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“…We conducted half-side test by topical corticosteroid and moisturizing agent, in which the former was more effective. He achieved mild remission of symptoms in a period of one month.Patients with chronic renal failure commonly exhibit cutaneous manifestations, such as pruritus, dry skin, hyperpigmentation, acquired perforating dermatosis, nephrogenic systemic fibrosis, calciphylaxis, porphyria cutanea tarda, and pseudoporphyria [1]. Furthermore, if dialysis is introduced, dialysis-related amyloidosis sometimes occurs during long-term course.…”

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confidence: 99%

Lichen amyloidosis associated with chronic renal failure

Matsumura¹,

Yamamoto²

2017

Our Dermatol Online

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A 58-year-old Japanese male visited the Department of Dermatology of Fukushima Medical University Hospital, complaining of itchy eruptions on his trunk and lower legs. The skin rash had previously been treated with topical antihistamine cream, but without improvement. He had a past history of diabetic nephropathy and has been received peritoneal dialysis for 9 months. The patient's family history was noncontributory. Physical examination revealed a number of papulonodular eruptions on the trunk and hyperpigmented, keratotic, and firm papules and nodules on the lower parts of thighs and upper parts of shins ( Fig. 1a and 1b). Skin biopsy taken from the left leg showed epidermal hyperkeratosis and deposition of amorphous eosinophilic substance in the papillary dermis, which was evident on Congo-red and antcytokeratin antibody 34βE12 staining (Fig. 2a-c). Immunohistochemical staining of the β2-microglobulin was negative. The clinical and histological findings confirmed lichen amyloidosis. We conducted half-side test by topical corticosteroid and moisturizing agent, in which the former was more effective. He achieved mild remission of symptoms in a period of one month.Patients with chronic renal failure commonly exhibit cutaneous manifestations, such as pruritus, dry skin, hyperpigmentation, acquired perforating dermatosis, nephrogenic systemic fibrosis, calciphylaxis, porphyria cutanea tarda, and pseudoporphyria [1]. Furthermore, if dialysis is introduced, dialysis-related amyloidosis sometimes occurs during long-term course. In dialysisrelated amyloidosis, skin manifestations often present with cutaneous or subcutaneous nodules [2]. Bilateral subcutaneous masses are seen on the buttocks,

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Primary Biliary Cholangitis Associated with Skin Disorders: A Case Report and Review of the Literature

Beretta‐Piccoli

Guillod

Marsteller

et al. 2017

Arch. Immunol. Ther. Exp.

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Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease. It is often associated with extrahepatic autoimmune diseases. Skin disorders are sporadically reported in association with PBC. We report an unusual case of PBC associated with acquired reactive perforating dermatosis (ARPD) and present a review of the literature on skin disorders associated with PBC. Our patient presented to the dermatology department with generalized pruritus associated with nodular perforating skin lesions on the trunk, and cholestatic liver disease of unknown origin. After having established both diagnosis of ARPD and PBC, she was managed in an interdisciplinary manner, and both her skin and liver conditions improved gradually. Only one similar case is reported in the literature, in that case, the liver disease was not treated. By reviewing the literature, we found that lichen planus, vitiligo, and psoriasis are the most frequent skin disorders associated with PBC. However, there is only limited data about specific skin disorders associated with PBC. This case report of a patient with PBC associated with ARPD underlines the importance of interdisciplinary management of patients with rare liver diseases combined with rare skin disorders. The present review of the literature shows that probably, immune-mediated skin conditions are not more frequent in PBC patients than in the general population. However, the available data are scant; there is a need for high-quality data on skin conditions associated with PBC.

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Skin manifestations of chronic kidney disease

Cited by 20 publications

References 49 publications

Dermatologic manifestations in end stage renal disease

Dermatologic manifestations in end stage renal disease

Lichen amyloidosis associated with chronic renal failure

Primary Biliary Cholangitis Associated with Skin Disorders: A Case Report and Review of the Literature

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