Skin manifestations of pentazocine abuse

Palestine, Roberta F.; Millns, John L.; Spigel, G. Thomas; Schroeter, Arnold L.

doi:10.1016/s0190-9622(80)80292-1

Cited by 94 publications

(42 citation statements)

References 23 publications

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“…Its use was prevalent in the USA in the 1970s, and interestingly, it was associated with pseudomonas infection in drug abusers secondary to its water-soluble preparation [5]. Pentazocine's destructive cutaneous manifestations including dermal fibrosis, granulomatous inflammation, and vascular thrombosis [7] are well described in the literature and were noted in this case. Tissue and wound cultures grew mixed flora including Gram-positive rods and cocci as well as M. morganii, a Gram-negative bacillus found in the human gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 79%

Case Report: Injectable Pentazocine Abuse Leading to Necrotizing Soft Tissue Infection and Florid Osteomyelitis

Mudrick

Isaacs

Frankenhoff

2011

Hand (New York, N,Y.)

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Section: Discussionmentioning

confidence: 79%

Case Report: Injectable Pentazocine Abuse Leading to Necrotizing Soft Tissue Infection and Florid Osteomyelitis

Mudrick

Isaacs

Frankenhoff

2011

Hand (New York, N,Y.)

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“…Abbreviations used in this paper: ACA, anticentromere autoantibodies; antitopo I, antitopoisomerase I; OR, odds ratio; PC, corrected P value; PCR, polymerase chain reaction; PSS, progressive systemic sclerosis; RFLP, restriction fragment length polymorphism. mental factors have been implicated (1)(2)(3)(4)(5)(6)(7). A number of studies have reported associations of HLA antigens with PSS, including MHC class I specificities: HLA-A9 (8,9), B8 (10,11 ), and B35 (12,13); MHC class II specificities: HLA-DR 1 (13)(14)(15)(16), DR3 (ll,17), and DR5 (16,(18)(19)(20); and MHC class III specificities: C4 null alleles (12,19).…”

Section: Introductionmentioning

confidence: 99%

Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis).

Reveille¹,

Durban²,

Clair³

et al. 1992

J. Clin. Invest.

132

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Previous studies in Caucasians with progressive systemic sclerosis (PSS) have suggested associations of antitopoisomerase I (antitopo I) autoantibodies with either serologically defined HLA-DR2 or DR5. To better define class II HLA associations with the antitopo I response, 161 PSS patients (132 Caucasians and 29 American blacks) were studied for antitopo I autoantibodies by immunodiffusion and immunoblotting, and their HLA-DRB1, DRB3, DQA1, and DQB1 alleles were determined by restriction fragment length polymorphic analysis and DNA oligotyping. Among Caucasians with antitopo I, HLA-DR5(DRB1*1101-*1104), DRB3*0202 and DQw3 (DQw7,8,9) were significantly increased in frequency. In American blacks, however, only HLA-DQB1 *0301 (DQw7) was significantly increased. The presence of HLA-DQB1 *0301 (DQw7) and other HLA-DQB1 alleles bearing the uncharged polar amino acid residue tyrosine at position 30 of the outermost domain was found in all antitopo I-positive Caucasian PSS patients compared with 66% of antitopo I-negative PSS patients (pc = 0.007) and 70% of normal controls (pc = 0.008), as well as all antitopo I-positive black patients. The association with HLA-DQB1 was independent of HLA-DR5(DRB1*1101-*1 104) or any other HLA-DRB1, DRB3, or DQA1 alleles. Alternative or additional candidate epitopes for this autoimmune response include alanine at position 38 and threonine at position 77 of these same DQB1 alleles. These data suggest that genetic predisposition to the antitopo I response in PSS is associated most closely with the HLA-DQB1 locus. (J. Clin. Invest. 1992. 90:973-980.)

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“…89 Pentazocine injections cause sclerodermoid plaques at the sites of injection secondary to thrombosis of small vessels and endoarteritis, with subsequent granulomatous inflammation, necrosis of adipocytes, lipophagic granuloma, and pronounced fibrosis of the dermis and connective septa of the subcutaneous tissue. 90 Vitamin K1 injections also cause sclerosis of the connective tissue septa of subcutaneous fat and an inflammatory infiltrate composed of lymphocytes and plasma cells, closely resembling the histopathologic findings of deep morphea. 91 Other drug-induced granulomas include sarcoidal granulomas at the sites of injection of interferon beta-1b for multiple sclerosis 92 and interferon alfa-2a for hepatitis C, 93 tuberculoid granulomas at the site of injection of zinc containing insulin, 94 necrobiotic palisading granulomas at the injection sites of hepatitis B vaccine 95 and disodium clodronate, 96 mixed granulomatous reaction combining sarcoidal and foreign body granulomas after depot injections of leuprorelin acetate for treatment of prostatic cancer, 97 and granulomas at the base of the penis after injection of acyclovir tablets dissolved in hydrogen peroxidase as self-treatment for recurrent genital herpes.…”

Section: Injected Drugsmentioning

confidence: 73%