Skin manifestations of rheumatoid arthritis: a study of 215 Turkish patients

Ergun, Tülin; İnanç, Nevsun; Tüney, Davut; Kotiloǧlu, Esin; Seçkin, Dilek; Tetik, Cihangir; Direşkeneli, Haner

doi:10.1111/j.1365-4632.2008.03708.x

Cited by 37 publications

(42 citation statements)

References 37 publications

(42 reference statements)

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“…However, in consonance with the previous studies,[46] there was a female preponderance in the present series. The mean age of presentation was much less in females (39.5 years) in comparison to that of the males (52 years).…”

Section: Discussionsupporting

confidence: 93%

“…[4] It is noteworthy that all of these areas are prone to friction. They may also occur internally in the spine, lung, heart valve, and gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

“…[5] However, a lower prevalence (9.3%) has been observed in Turkish patients. [4] Yamamoto et al . also described an extraordinarily lower frequency (<2%) in Japanese patients.…”

Section: Discussionmentioning

confidence: 99%

“…[2] A large number of specific and nonspecific mucocutaneous manifestations are associated with RA. [34] As with other extraarticular manifestations, dermatologic involvement tends to occur in patients with more severe RA. [5]…”

Section: Introductionmentioning

confidence: 99%

“…[3] The disease severity as well as the prevalence of extraarticular manifestations shows geographic variations. [4] PubMed and MEDLINE database search revealed that apart from a few studies on Western population,[46] there is a dearth of data on this subject, particularly on Indian population which prompted us to undertake the present study. The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India.…”

Section: Introductionmentioning

confidence: 99%

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Mucocutaneous manifestations in patients with rheumatoid arthritis: A cross-sectional study from Eastern India

et al. 2017

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Background:Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease.Aims:The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India.Methodology:Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India. Thorough clinical examination and appropriate laboratory investigations were performed as needed. Data were recorded in a predesigned schedule, and appropriate statistical analysis was done.Results:We studied 111 evaluable patients with an age range of 19–71 years and a female to male ratio of 7:1. The mean disease duration of RA was 6.5 years. Cutaneous infections as a group was the most common mucocutaneous manifestation (34.2%) followed by xerosis including ichthyotic skin changes (27%), pigmented purpuric dermatoses (14.4%), leg ulcer (9.9%), periungual telangiectasia (9.9%), rheumatoid nodules (RNs) (8.1%), purpura and ecchymoses (7.2%), small vessel vasculitis in (7.2%), corn and callosities (6.3%), palmar erythema (4.5%), and neutrophilic dermatosis (4.5%). Raynaud's phenomenon was found in 3.6% patients and panniculitis in (3.6%) patients. Rheumatoid factor (RF) and anti-cyclic citrullinated peptides antibody were positive in 74.8% and 88.3% patients, respectively. No statistically significant difference of incidence of leg ulcer, small vessel vasculitis, RN, or Raynaud's phenomenon could be noted between RF positive and negative groups.Limitations:Being an institution-based study, the study findings may not reflect the true situation in the community which remained a limitation of this study.Conclusion:While some of the features of this study were analogous to Western data, other features showed discordance which may be due to ethnic variations among the patients with RA.

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Section: Discussionsupporting

confidence: 93%

“…[4] It is noteworthy that all of these areas are prone to friction. They may also occur internally in the spine, lung, heart valve, and gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

“…[5] However, a lower prevalence (9.3%) has been observed in Turkish patients. [4] Yamamoto et al . also described an extraordinarily lower frequency (<2%) in Japanese patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mucocutaneous manifestations in patients with rheumatoid arthritis: A cross-sectional study from Eastern India

et al. 2017

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Undifferentiated and Mixed Connective Tissue Disease and Dermatological Manifestations of Rheumatoid Disease

Laws

2024

Rook's Textbook of Dermatology

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Undifferentiated connective tissue disease (UCTD) and mixed connective tissue diseases (MCTD) include a spectrum of rheumatological signs and symptoms which overlap with traditional connective tissue diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc) and dermatomyositis (DM) (the reader is directed to relevant chapters for discussion of SLE, DM and SSc). Describing the clinical features associated with UCTD and MCTD is inherently challenging due to the difficulties classifying overlap disorders precisely and the variable nomenclature in the literature. Despite this challenge the dermatologist has a key role in early recognition and diagnosis of affected patients. While the majority of rheumatological disease management focuses on controlling or reducing joint symptoms, several conditions have cutaneous features which may indicate active disease, impact on morbidity and negatively affect quality of life. In addition to UCTD and MCTD other rheumatic diseases which have significant cutaneous features include: rheumatoid arthritis, Sjogren syndrome, Still syndrome and rheumatic fever. This chapter provides an overview to these conditions with specific reference to cutaneous features. Appreciating the spectrum of dermatological manifestations associated with rheumatological disease and how these impact on the individual patient is important to promoting holistic, patient‐centred care. Close collaboration between dermatologists and rheumatologists is an essential prerequisite in supporting effective diagnosis and treatment of this complex cohort of patients.

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Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report

Rodwan

Mohammed

Essa

et al. 2022

Clinical Case Reports

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Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad‐spectrum clinical manifestation of various organs. RND is an unusual distinctive manifestation of RA and typically develops in severe RA. This report aims to present an unusual and a rare neutrophilic skin condition, in a seronegative RA Sudanese patient. A 51‐year‐old woman was diagnosed with RA three years ago and a history of bilateral polyarthritis, presented with a skin rash involving her extremities and abdomen. Clinical examination of her skin revealed the presence of maculopapular lesions affecting the extensor surfaces of the lower extremities and the lower part of the abdomen with hyperpigmentation. Hand X‐ray demonstrated periarticular osteopenia, and laboratory and immunological studies that include C‐reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anticitrullinated peptide antibodies (ACPAs), and antinuclear factor in addition to skin biopsy were all suggested a diagnosis of neutrophilic dermatosis. The patient received steroids for the skin lesion still no significant improvement was seen, and then, cyclosporin 100 mg was administrated twice/ day with close monitoring, and two weeks later marked improvement was shown.

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Skin manifestations of rheumatoid arthritis: a study of 215 Turkish patients

Cited by 37 publications

References 37 publications

Mucocutaneous manifestations in patients with rheumatoid arthritis: A cross-sectional study from Eastern India

Mucocutaneous manifestations in patients with rheumatoid arthritis: A cross-sectional study from Eastern India

Undifferentiated and Mixed Connective Tissue Disease and Dermatological Manifestations of Rheumatoid Disease

Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report

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