Skin microbiome of atopic dermatitis

Koh, Li Fang; Ong, Ruo Yan; Common, John E.A.

doi:10.1016/j.alit.2021.11.001

Cited by 88 publications

(67 citation statements)

References 112 publications

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“…The skin of patients with AD is overrepresentation of pathogenic S. aureus . 8 A greater susceptibility to AD disease process may also be attributed to the decreased expression of AMPs in the skin and an increase in the relative abundance of S. aureus . S. aureus communicates through quorum sensing, especially through the accessory gene regulator (agr) system.…”

Section: Introductionmentioning

confidence: 99%

Effects of wearing personal protective equipment during COVID‐19 pandemic on composition and diversity of skin bacteria and fungi of medical workers

Xiao-qin

Chen

et al. 2022

Acad Dermatol Venereol

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Background During the COVID-19 pandemic, wearing PPE can induce skin damage such as erythema, pruritus, erosion, and ulceration among others. Although the skin microbiome is considered important for skin health, the change of the skin microbiome after wearing PPE remains unknown.Objective The present study aimed to characterize the diversity and structure of bacterial and fungal flora on skin surfaces of healthcare workers wearing personal protective equipment (PPE) during the COVID-19 pandemic using metagenomic next-generation sequencing (mNGS).Methods A total of 10 Chinese volunteers were recruited and the microbiome of their face, hand, and back were analysed before and after wearing PPE. Moreover, VISIA was used to analyse skin features. Results Results of alpha bacterial diversity showed that there was statistically significant decrease in alpha diversity indice in the skin samples from face, hand, and three sites after wearing PPE as compared with the indice in the skin samples before wearing PPE. Further, the results of evaluated alpha fungal diversity show that there was a statistically significant decrease in alpha diversity indices in the skin samples from hand after wearing PPE as compared with the indices in the skin samples before wearing PPE (P < 0.05). Results of the current study found that the main bacteria on the face, hand, and back skin samples before wearing the PPE were Propionibacterium spp. (34.04%), Corynebacterium spp. (13.12%), and Staphylococcus spp. (38.07%). The main bacteria found on the skin samples after wearing the PPE were Staphylococcus spp. (31.23%), Xanthomonas spp. (26.21%), and Cutibacterium spp. (42.59%). The fungal community composition was similar in three skin sites before and after wearing PPE. ConclusionIt was evident that wearing PPE may affect the skin microbiota, especially bacteria. Therefore, it was evident that the symbiotic microbiota may reflect the skin health of medical workers during the COVID-19 pandemic.

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Section: Introductionmentioning

confidence: 99%

Effects of wearing personal protective equipment during COVID‐19 pandemic on composition and diversity of skin bacteria and fungi of medical workers

Xiao-qin

Chen

et al. 2022

Acad Dermatol Venereol

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“…These include the fungal family Malassezia spp. [8,9]. These lipophilic fungi require an alkaline pH for growth.…”

Section: Discussionmentioning

confidence: 99%

Study of Hypersensitivity to Malassezia furfur in Patients with Atopic Dermatitis with Head and Neck Pattern: Is It Useful as a Biomarker and Therapeutic Indicator in These Patients?

Navarro‐Triviño

Ayén‐Rodríguez

2022

Life

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Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory diseases. Head and neck (H&N) involvement, also known as the picture-frame pattern, can be a diagnostic and even therapeutic challenge. Sensitization to the fungus Malassezia furfur seems to be implicated in this clinical presentation. To investigate the role of Malassezia furfur in H&N dermatitis, we performed an observational single-centre study. Serum-specific IgE levels for Malassezia furfur were determined in a total of 25 patients with AD (15 receiving dupilumab treatment, 10 not receiving dupilumab), 14 patients with seborrheic dermatitis, and 19 healthy controls. Reactivity to Malassezia Furfur, in terms of serum-specific IgE levels (>0.35 Ku.arb./L), was found in 80% of patients with AD. Risk factors to consider include high total IgE levels, sensitization to multiple pneumoallergens, and elevated LDH and CRP levels. Prescription of topical antifungals, oral antifungals, or a combination of both showed good response in 100% of cases in the H&N AD group treated with dupilumab. The most appropriate treatment seems to be the use of oral itraconazole and/or ketoconazole cream. The median treatment time was 3 weeks. Localized dermatitis in H&N significantly affects the patient’s life. We present a study of sensitization to Malassezia furfur in patients with H&N AD. It is important to know the differential diagnosis and to approach the study correctly. Sensitization to Malassezia furfur may be one of the main reasons, especially in patients being treated with dupilumab. The use of antifungals allows for adequate control, avoiding treatment changes and improving the patient’s quality of life.

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“…It is known that changes in the composition of the microbiome-dysbiosis-are linked to the pathogenesis of certain conditions (cardiovascular, gastrointestinal, metabolic, and neurodegenerative diseases and cancer) and can increase the risk of others, including allergic diseases such as asthma, allergic rhinitis, atopic dermatitis (AD), and food allergy (Figure 1) [9][10][11][12][13][14][15][16][17][18].…”

Section: Human Microbiome/microbiotamentioning

confidence: 99%

Microbiome and Allergy: New Insights and Perspectives

Zubeldia-Varela¹,

Barker-Tejeda²,

Obeso³

et al. 2022

J Investig Allergol Clin Immunol

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The role of the microbiome in the molecular mechanisms underlying allergy has become highly relevant in recent years. Studies are increasingly suggesting that altered composition of the microbiota, or dysbiosis, may result in local and systemic alteration of the immune response to specific allergens. In this regard, a link has been established between lung microbiota and respiratory allergy, between skin microbiota and atopic dermatitis, and between gut microbiota and food allergy. The composition of the human microbiota is dynamic and depends on host-associated factors such as diet, diseases, and lifestyle. Omics are the techniques of choice for the analysis and understanding of the microbiota. Microbiota analysis techniques have advanced considerably in recent decades, and the need for multiple approaches to explore and comprehend multifactorial diseases, including allergy, has increased. Thus, more and more studies are proposing mechanisms for intervention in the microbiota. In this review, we present the latest advances with respect to the human microbiota in the literature, focusing on the intestinal, cutaneous, and respiratory microbiota. We discuss the relationship between the microbiome and the immune system, with emphasis on allergic diseases. Finally, we discuss the main technologies for the study of the microbiome and interventions targeting the microbiota for prevention of allergy.

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Skin microbiome of atopic dermatitis

Cited by 88 publications

References 112 publications

Effects of wearing personal protective equipment during COVID‐19 pandemic on composition and diversity of skin bacteria and fungi of medical workers

Effects of wearing personal protective equipment during COVID‐19 pandemic on composition and diversity of skin bacteria and fungi of medical workers

Study of Hypersensitivity to Malassezia furfur in Patients with Atopic Dermatitis with Head and Neck Pattern: Is It Useful as a Biomarker and Therapeutic Indicator in These Patients?

Microbiome and Allergy: New Insights and Perspectives

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