Skin movement, wound repair and development of engineered skin

Herskovitz, Ingrid; MacQuhae, Flor; Fox, Joshua; Kirsner, Robert S.

doi:10.1111/exd.12916

Cited by 18 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skin is the biggest organ of the human body, which has a lot of functions, some of them are protection, sensation, thermoregulation, control of evaporation etc. Skin includes two anatomically, functionally, and developmentally distinct tissues: the epidermis, which has a role of barrier to infection and regulator of transdermal water loss, and the dermis, which has mechano and thermoreceptors, hair follicles, different glands and vessels [140]. When developing biomaterials for skin regeneration, it is important to remember that the main components of a successful biomaterial are ECM, cells and bioactive molecules that help cell growth or differentiation [141,142] In the case of the development of skin implants, scientists can start using not only pure polymers, because the restoration of the skin occurs much faster if one uses various combinations of polymers with nano- [143] or micro- [67] particles and bioactive substances [144].…”

Section: Hybrid Biomaterials Applied For Skinmentioning

confidence: 99%

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

View full text Add to dashboard Cite

In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed. Pure polymer based biomaterials are predominantly used to target soft tissues. Stipulated by possibilities of tuning the composition and concentration of their inorganic content, hybrid materials allow to mimic properties of various types of harder tissues. That leads to the concept of "one-matches-all" referring to materials possessing the same polymeric base, but different inorganic content to enable tissue growth and repair, proliferation of cells, and the formation of the ECM (extra cellular matrix). Furthermore, adding drug delivery carriers to coatings and scaffolds designed with such materials brings additional functionality by encapsulating active molecules, antibacterial agents, and growth factors. We discuss here materials and methods of their assembly from a general perspective together with their applications in various tissue engineering sub-areas: interstitial, connective, vascular, nervous, visceral and musculoskeletal tissues. The overall aims of this review are two-fold: (a) to describe the needs and opportunities in the field of bio-medicine, which should be useful for material scientists, and (b) to present capabilities and resources available in the area of materials, which should be of interest for biologists and medical doctors.Polymers 2020, 12, 620 2 of 30 allows to tailor functionalize the coatings, where their responsiveness to external stimuli is one of their biggest advantages.Polymers stand out as a special class of materials due to the flexibility of design of their blocks and various functionalities, which is brought by their versatile assembly or by introducing additional side-groups or blocks, in the case of block-co-polymers. In this regard, both synthetic and biocompatible polymers are available, and polymer engineering represents a growing area tailoring the needs often driven by applications. With all advantages and the flexibility of the design, there is one significant weakness of polymers-the softness. In regard with tissue engineering, that translates to the fact that some materials can match predominantly soft tissue, but it is difficult to tune mechanical properties of polymers to match the hardness of bones, tendons, etc. And since mechanical properties of materials affect and even drive cell and tissue growth, enhancement of mechanical properties of polymers and biomaterials is essential. Chemical crosslinking can be applied to address these challenges, but that solves problems only partially.To solve these challenges the so-called hybrid materials [6] are used, which possess both inorganic and organic contents. Increasingly, hybrid materials are used in designing the extracellular matrix. The hybrid matrix design for various tissue engineering applications should meet bio-medical requirements. On the one hand, it needs to be biocompatible and biodegradable, which is achieved through the po...

show abstract

Section: Hybrid Biomaterials Applied For Skinmentioning

confidence: 99%

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

View full text Add to dashboard Cite

show abstract

“…Antioxidant plays a major role in protecting our body from disease by reducing the oxidative damage to cellular component caused by Reactive Oxygen Species while antibacterial are the agents acts against diseases or infection causing bacterial species. In the present study we tried to made a topical skin care formulation using plant extracts that offers protection against malignancies, ageing, skin infections and other damaging effects on the skin [1,2,3] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant and antibacterial potential poly herbal skin care cream

Sharma¹,

Dwivedi²

2023

J. Med. Plants Stud.

View full text Add to dashboard Cite

Plants has all remedy to alleviate from suffering of human were recognized from ancient times and human were used various plant parts, plant material and plant products to restore the health as well as to get rid of distress and suffering. Skin is the largest protective organ that came in to direct contact with outer harmful agents that might get affects the skin health and functions. UV radiation, pollution, diseases causing organism and certain intrinsic factors are the major causes to defile the skin health and functions, so the protection of skin is utmost important to maintain the proper skin health. Cosmetics are the agents used to beautify, clean, alter, nourish and protect the skin from intrinsic as well as from extraneous factors. Numerous cosmetic agents are available in the market to ensure the protection against these harmful agents. Safety and biocompatibility are the major concern with the synthetic cosmetics inclined people towards herbal or natural cosmetics agents. Herbal or natural cosmetic have got more attention in the recent years due to lesser side effect, biocompatibility to skin, cost effectiveness, traditional experience of uses and availability. Increasing demand of herbal cosmetics incited to explore the new herbal substance from plant origin that could give better alternative in the cluster of existing formulation In the present study we have tried to formulate a skin care preparation that might be give better alternative for the protection of skin as well as favors to maintain the skin health.

show abstract

“…Wound healing is a fundamental physiological process crucial for maintaining tissue integrity and restoring normal function following injury (Gonzalez et al 2016). Skin plays a pivotal role in protecting underlying tissues and organs from external factors (Herskovitz et al 2016). Impaired wound healing can lead to chronic wounds, infections, and severe health complications.…”

Section: Introductionmentioning

confidence: 99%

Wound Healing and Skin Regeneration: Present Status and Future Directions

Banu,

Sharun,

Mamachan

et al. 2023

J Exp Bio & Ag Sci

View full text Add to dashboard Cite

Wound healing and skin regeneration involve intricate interactions between various cellular, molecular, and biochemical factors. This narrative review aims to provide an in-depth analysis of the present status of therapeutic strategies for wound healing and skin regeneration. The literature review was performed using the Google Scholar search engine with the help of relevant keywords. Selected publications were used to synthesize different sections of the narrative review. The quest for innovative therapeutic approaches to accelerate wound healing and enhance skin regeneration has led to remarkable advancements in recent years. The landscape of therapeutic approaches for wound healing and skin regeneration is evolving rapidly, driven by groundbreaking discoveries and interdisciplinary collaborations. From advanced wound dressings and growth factor therapies to stem cell-based interventions and gene editing techniques, the arsenal of tools at our disposal continues to expand. As researchers continue to unravel the intricate mechanisms underlying wound repair and regeneration, the potential for transformative therapies to revolutionize patient care remains immense. Through a combination of innovative technologies, personalized approaches, ethical considerations, and global accessibility, the future of wound healing holds promise for improving the lives of countless individuals worldwide. Despite significant advancements, several knowledge gaps persist in the field of wound healing and skin regeneration. Further elucidation of cellular and molecular mechanisms governing wound repair, inflammation resolution, and scar formation is warranted. Exploring the crosstalk between wound healing and the microbiome and the influence of ageing and systemic diseases will unravel new therapeutic targets and strategies. As researchers delve deeper into understanding the intricate mechanisms underlying wound repair, the development of novel therapies and their clinical translation become increasingly promising. With a multidisciplinary approach and ongoing advancements in technology, biology, and medicine, the future holds great potential for transforming the field of wound healing and skin regeneration.

show abstract

Skin movement, wound repair and development of engineered skin

Cited by 18 publications

References 14 publications

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Evaluation of antioxidant and antibacterial potential poly herbal skin care cream

Wound Healing and Skin Regeneration: Present Status and Future Directions

Contact Info

Product

Resources

About