Skin needling as a treatment for acne scarring: An up-to-date review of the literature

Harris, Andrew G.; Naidoo, Catherine; Murrell, Dédée F.

doi:10.1016/j.ijwd.2015.03.004

Cited by 31 publications

(25 citation statements)

References 48 publications

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“…(23) , this side effect occurred in 1 patient (10%). Similar to previous studies Harrris et al (24) , bacterial infection not occurred in any of our patients.…”

Section: Discussionsupporting

confidence: 93%

Efficacy of microneedling in treatment of acne scars

Nada

Abdo

Mohhmed

et al. 2018

Sohag Medical Journal

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Introduction: Microneedling is a relatively new minimally invasive procedure involving superficial and controlled puncturing of the skin by rolling with miniature fine needles. Traditionally used as a collagen induction therapy for skin rejuvenation and facial scars specially acne scars. Aim of the work: Evaluation of efficacy of microneedling in treatment of acne scars. Patients and Methods: Ten patients with post acne atrophic facial scars attending the outpatient clinic of Dermatology in Sohag University Hospitals between June2014 to September 2017 were offered six sessions of microneedling at an interval of 1 month. They were evaluated monthly and one month after completion of sessions for both efficacy and safety of the procedure. Results: The mean ± SD of the patients' age in the study population were26.900±5.952years old.eight females and two males with mean acne scars duration ± SD 8.500±6.311 years, 60% of patients had psychological distress from their acne scars. At the end of study duration Out of the ten patients 7(70%) achieved one grade reduction in their Goodman and Baron qualitative grading score while 4 patients (40%) achieved reduction in their quantitative ECCA " Echella d'e valuation Clinique des cicatrices d'acne" score with 8.55% improvement in the ECCA score. The mean ECCA score value of V scar started to decrease earlier than U scar , but M scar was fixed up to end of sessions. 50% of patients had good satisfaction, 30% of them had very good satisfaction and only 10% had excellent satisfaction. All treated patients , had adverse events of temporary erythema, edema, bleeding, or a serous ooze resolving with crusting or scabbing following each session of microneedling but in 1 patient (10%) aggravation of acne occurred, bacterial infection not occurred in any of our patients. Conclusion: Multiple minimally invasive sessions of skin microneedling is an effective treatment for post-acne atrophic scars with the advantage of being a relatively risk-free, inoffice procedure with minimal patient recovery time.

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“…(23) , this side effect occurred in 1 patient (10%). Similar to previous studies Harrris et al (24) , bacterial infection not occurred in any of our patients.…”

Section: Discussionsupporting

confidence: 93%

Efficacy of microneedling in treatment of acne scars

Nada

Abdo

Mohhmed

et al. 2018

Sohag Medical Journal

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“…From a safety standpoint, it is desirable for the created pores to close soon after microneedle removal to prevent permeation of undesired substances or pathogenic microorganisms [41]. The pores are expected to close as a physiological response, due to the skin's natural repair mechanisms [42]. Upon disruption of the stratum corneum barrier, lamellar body secretion is immediately initiated, followed by synthesis of lipids to restore and maintain the barrier [43].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

Al-Kasasbeh

Brady

Courtenay

et al. 2020

Drug Deliv. and Transl. Res.

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Hydrogel-forming microneedle array patches (MAPs) have been proposed as viable clinical tools for patient monitoring purposes, providing an alternative to traditional methods of sample acquisition, such as venepuncture and intradermal sampling. They are also undergoing investigation in the management of non-melanoma skin cancers. In contrast to drug or vaccine delivery, when only a small number of MAP applications would be required, hydrogel MAPs utilised for sampling purposes or for tumour eradication would necessitate regular, repeat applications. Therefore, the current study was designed to address one of the key translational aspects of MAP development, namely patient safety. We demonstrate, for the first time in human volunteers, that repeat MAP application and wear does not lead to prolonged skin reactions or prolonged disruption of skin barrier function. Importantly, concentrations of specific systemic biomarkers of inflammation (C-reactive protein (CRP); tumour necrosis factor-α (TNF-α)); infection (interleukin-1β (IL-1β); allergy (immunoglobulin E (IgE)) and immunity (immunoglobulin G (IgG)) were all recorded over the course of this fixed study period. No biomarker concentrations above the normal, documented adult ranges were recorded over the course of the study, indicating that no systemic reactions had been initiated in volunteers. Building upon the results of this study, which serve to highlight the safety of our hydrogel MAP, we are actively working towards CE marking of our MAP technology as a medical device.

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“…Microneedle arrays have a wide range of uses from cosmetic 14 , 15 (e.g. Dermaroller™), diagnostic 16 , 17 , drug delivery 18 – 20 through to the most promising and most studied area, vaccine delivery 21 .…”

Section: Introductionmentioning

confidence: 99%

Innate local response and tissue recovery following application of high density microarray patches to human skin

Muller

Henricson

Baker

et al. 2020

Sci Rep

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The development of microarray patches for vaccine application has the potential to revolutionise vaccine delivery. Microarray patches (MAP) reduce risks of needle stick injury, do not require reconstitution and have the potential to enhance immune responses using a fractional vaccine dose. To date, the majority of research has focused on vaccine delivery with little characterisation of local skin response and recovery. Here we study in detail the immediate local skin response and recovery of the skin post high density MAP application in 12 individuals receiving 3 MAPs randomly assigned to the forearm and upper arm. Responses were characterised by clinical scoring, dermatoscopy, evaporimetry and tissue viability imaging (TiVi). MAP application resulted in punctures in the epidermis, a significant transepidermal water loss (TEWL), the peak TEWL being concomitant with peak erythema responses visualised by TiVi. TEWL and TiVi responses reduced over time, with TEWL returning to baseline by 48 h and erythema fading over the course of a 7 day period. As MAPs for vaccination move into larger clinical studies more variation of individual subject phenotypic or disease propensity will be encountered which will require consideration both in regard to reliability of dose delivery and degree of inherent skin response.

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Skin needling as a treatment for acne scarring: An up-to-date review of the literature

Cited by 31 publications

References 48 publications

Efficacy of microneedling in treatment of acne scars

Efficacy of microneedling in treatment of acne scars

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

Innate local response and tissue recovery following application of high density microarray patches to human skin

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