Skin of the dorsal aspect of human hands and fingers possesses an active vasodilator system

Johnson, John M.; Pèrgola, Pablo E.; Liao, Fuyuan; Kellogg, Dean L.; Crandall, Craig G.

doi:10.1152/jappl.1995.78.3.948

Cited by 88 publications

(69 citation statements)

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“…Previous studies reported that sympathetically-mediated vasoconstriction is evoked in the glabrous skin during cold stress (8,14) and dynamic or isometric exercise (11,18,22). This sympathetically-mediated vasoconstriction in the hand might also be evoked by concentrated finger perception tasks, which in turn contributes to reducing the flow velocity and volume flow of the radial artery.…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, the glabrous skin is innervated by sympathetic adrenergic vasoconstrictor nerves, but lacks influence from active vasodilator nerves (8,9). Previous studies reported that sympathetically-mediated vasoconstriction is evoked in the glabrous skin during cold stress (8,14) and dynamic or isometric exercise (11,18,22).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, it is well known that the glabrous skin of the hand contains rich arteriovenous anastomoses (AVA), which are densely innervated by sympathetic vasoconstrictor fibers (8,9,19). The vasoconstrictor system plays a role in reflex adjustments to thermal and exercise challenges (1,7,8,11,17,18,21,22).…”

Section: Introductionmentioning

confidence: 99%

“…The vasoconstrictor system plays a role in reflex adjustments to thermal and exercise challenges (1,7,8,11,17,18,21,22). Since Macefield and Elam (3,12) reported that firing of tactile afferents in the human finger pads had a relationship with arterial pulsation occurring within the finger, it is likely that regulation of blood flow to the fingers plays an important role in not only thermoregulatory modulation but also the aforementioned sensory mechanism.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Modulation of radial blood flow during Braille character discrimination task

Murata¹,

Matsukawa²,

Komine³

et al. 2012

Acta Physiologica Hungarica

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Purpose: Human hands are excellent in performing sensory and motor function. We hypothesized that blood flow of the hand are dynamically regulated by sympathetic outflow during concentrated finger perception. To identify this hypothesis, we measured radial blood flow (RBF), radial vascular conductance (RVC), heart rate (HR), and arterial blood pressure (AP) during Braille reading performed under the blind condition in nine healthy subjects. The subjects were instructed to read a flat plate with raised letters (Braille reading) for 30 s by the forefinger, and to touch a blank plate as control for the Braille discrimination procedure.Results: HR and AP slightly increased during Braille reading but remained unchanged during the touching of the blank plate. RBF and RVC were reduced during the Braille character discrimination task (decreased by -46% and -49%, respectively).Furthermore, the changes in RBF and RVC were much greater during the Braille character discrimination task than during the touching of the blank plate (decreased by -20% and -20%, respectively). Conclusions:These results suggested that the distribution of blood flow to the hand is modulated via sympathetic nerve activity during concentrated finger perception.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of radial blood flow during Braille character discrimination task

Murata¹,

Matsukawa²,

Komine³

et al. 2012

Acta Physiologica Hungarica

View full text Add to dashboard Cite

show abstract

“…The subjects of this study included healthy Japanese women between 25 and 35 y of age. This study was approved by the Ethics Committee of the Kao Corporation in accordance with the principles of the Declaration of Helsinki (Approval number: [13][14][15][16][17][18][19][20][21][22][23][24]. In addition, subjects only participated after receiving a sufficient explanation of the purpose and content of the study and providing informed consent.…”

Section: Methodsmentioning

confidence: 99%

Ingestion of Coffee Polyphenols Improves a Scaly Skin Surface and the Recovery Rate of Skin Temperature after Cold Stress: A Randomized, Controlled Trial

Ueda

Tanahashi

Higaki

et al. 2017

J Nutr Sci Vitaminol

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Summary Coffee polyphenols (CPPs) derived from coffee beans have beneficial effects on blood pressure and vascular endothelial function. In addition, CPPs suppress ultraviolet light induced erythema. However, the effects of CPPs on dry skin and cutaneous vascular function have not been clarified. We investigated the effects of CPPs on dry skin and the recovery rate (RR) of skin temperature after a cold-stress test as a measure of vascular function in subjects with visible scaliness in a double-blind, placebo-controlled, randomized study. The subjects were divided into two groups, the CPP group and the Placebo group. In the CPP group, the subjects ingested a beverage containing 297.8 mg CPPs every day for 4 wk. The degree of skin dryness was assessed quantitatively using a Visioscan to evaluate skin scaliness and smoothness. A subjective evaluation using a visual analog scale (VAS) of skin smoothness was also used. As a result, the scaliness and smoothness of cheek skin was significantly improved after 4 wk in the CPP group compared to the Placebo group. The improvements of the VAS score on 'skin smoothness' and the RR were also observed in the CPP group but the difference was not statistically significant. However, when the CPP group was divided into subgroups of high RR and low RR, the improvement of the RR was significant in the low RR subgroup. In conclusion, our results suggest that CPPs improve skin scaliness and play a role in cutaneous blood flow regulation after cold stress.

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Cutaneous Vasodilator and Vasoconstrictor Mechanisms in Temperature Regulation

Johnson

Minson

Kellogg

2014

Comprehensive Physiology

338

290

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In this review, we focus on significant developments in our understanding of the mechanisms that control the cutaneous vasculature in humans, with emphasis on the literature of the last half-century. To provide a background for subsequent sections, we review methods of measurement and techniques of importance in elucidating control mechanisms for studying skin blood flow. In addition, the anatomy of the skin relevant to its thermoregulatory function is outlined. The mechanisms by which sympathetic nerves mediate cutaneous active vasodilation during whole body heating and cutaneous vasoconstriction during whole body cooling are reviewed, including discussions of mechanisms involving cotransmission, NO, and other effectors. Current concepts for the mechanisms that effect local cutaneous vascular responses to local skin warming and cooling are examined, including the roles of temperature sensitive afferent neurons as well as NO and other mediators. Factors that can modulate control mechanisms of the cutaneous vasculature, such as gender, aging, and clinical conditions, are discussed, as are nonthermoregulatory reflex modifiers of thermoregulatory cutaneous vascular responses.

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Skin of the dorsal aspect of human hands and fingers possesses an active vasodilator system

Cited by 88 publications

References 0 publications

Modulation of radial blood flow during Braille character discrimination task

Modulation of radial blood flow during Braille character discrimination task

Ingestion of Coffee Polyphenols Improves a Scaly Skin Surface and the Recovery Rate of Skin Temperature after Cold Stress: A Randomized, Controlled Trial

Cutaneous Vasodilator and Vasoconstrictor Mechanisms in Temperature Regulation

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