Skin-penetrating polymeric nanoparticles incorporated in silk fibroin hydrogel for topical delivery of curcumin to improve its therapeutic effect on psoriasis mouse model

Mao, Kaili; Fan, Zhihai; Yuan, Jiandong; Chen, Pian-Pian; Yang, Jingjing; Xu, Jie; ZhuGe, De‐Li; Jin, Bing-Hui; Zhu, Qunyan; Shen, Bi-Xin; Sohawon, Yasin; Zhao, Ying‐Zheng; Xu, He‐Lin

doi:10.1016/j.colsurfb.2017.10.029

Cited by 111 publications

(61 citation statements)

References 39 publications

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“…Finally the curcumin encapsulated nanoparticle incorporated in silk fibrin hydrogel. It was confirmed by the in vivo studies that polymeric nanoparticle‐loaded silk fibrin hydrogel can diffuse from the stratum corneum and reside in a deeper layer, which ultimately decreases the level of TNF‐α, NF‐κB, and IL‐6 …”

Section: Introduction To Psoriasismentioning

confidence: 84%

“…86 Mao et al, demonstrated novel self-diffusible polymeric nanoparticle loaded in silk fibrin hydrogel as gold standard for targeting drug delivery. 87 RRR-a-tocopheryl succinate-grafted-epolylysine conjugate (VES-g-e-PLL) based self-assembled polymeric nanoparticles were encapsulated with curcumin. Prepared nanoparticles exhibited enhanced skin penetrability because of its characteristics such as positive charge and hydrodynamic diameter (24.4 nm).…”

Section: Recent Updates On Psoriasismentioning

confidence: 99%

“…Mao et al ., demonstrated novel self‐diffusible polymeric nanoparticle loaded in silk fibrin hydrogel as gold standard for targeting drug delivery . RRR‐ α ‐tocopheryl succinate‐grafted‐ε‐polylysine conjugate (VES‐g‐ ε ‐PLL) based self‐assembled polymeric nanoparticles were encapsulated with curcumin.…”

Section: Introduction To Psoriasismentioning

confidence: 99%

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Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches

Todke

Shah

2018

Int J Dermatology

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Skin is the most visible and vulnerable organ of the integumentary system. Psoriasis is a chronic inflammatory skin disorder with an equal prevalence rate in males and females globally. Psoriasis is seen today beyond a cosmetic turmoil as it significantly impacts the socioeconomic life of the patients. Patients with severe psoriasis report feeling denounced and isolated. Despite detailed understanding of the molecular mechanisms and pathogenesis of psoriasis, issues like the autoimmune cause of inflammation and role of external, genetic, cutaneous, and systemic factors on initiation, progression, and treatment of psoriasis are still ambiguous. The present review summarizes immunogenic pathophysiology of psoriasis with a cascade of events from stimuli-based release of self-nucleotides to the hyperproliferation of keratinocytes leading to psoriasis. The review emphasizes challenges and hurdles toward the efficient treatment of psoriasis. The review also provides a detailed understanding of conventional and novel treatment strategies including drug delivery approaches and patented technologies for therapeutic and preventive approaches leading to improved outcome for psoriasis patients. The review summarizes a brief insight on biologics and gene therapy that has resulted in a paradigm shift in the treatment strategies for psoriasis management.

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Section: Introduction To Psoriasismentioning

confidence: 84%

Section: Recent Updates On Psoriasismentioning

confidence: 99%

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Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches

Todke

Shah

2018

Int J Dermatology

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“…In another study, Mao et al reported that fibroin, in its hydrogel form, can enhance the transdermal delivery of the incorporated curcumin loaded polymeric NPs in psoriatic mouse model (Mao et al, 2017). Curcumin is a highly lipophilic compound that is easily trapped in the stratum corneum.…”

Section: Transdermal Administrationmentioning

confidence: 99%

Fibroin nanoparticles: a promising drug delivery system

2020

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Fibroin is a dominant silk protein that possesses ideal properties as a biomaterial for drug delivery. Recently, the development of fibroin nanoparticles (FNPs) for various biomedical applications has been extensively studied. Due to their versatility and chemical modifiability, FNPs can encapsulate different types of therapeutic compounds, including small and big molecules, proteins, enzymes, vaccines, and genetic materials. Moreover, FNPs are able to be administered both parenterally and non-parenterally. This review summaries basic information on the silk and fibroin origin and characteristics, followed by the up-to-date data on the FNPs preparation and characterization methods. In addition, their medical applications as a drug delivery system are in-depth explored based on several administrative routes of parenteral, oral, transdermal, ocular, orthopedic, and respiratory. Finally, the challenges and suggested solutions, as well as the future outlooks of these systems are discussed.

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“…Because of its the hydrophobicity, low bioavailability, and chemical instability, a variety of advanced formulations to improve its therapeutic efficacy have been reported [ 21 , 22 , 23 , 24 , 25 ] and recently reviewed [ 26 , 27 , 28 ]. The most recent ones include nanoemulsions [ 21 , 29 ], nanohydrogels [ 22 ], nanoparticles [ 25 , 30 ] with a focus on CS [ 5 ] and nanoparticles in hydrogels [ 31 , 32 ], nanostructured lipid carriers [ 33 ], lipid-based self-nanoemulsifying systems [ 34 ], and ethosomes [ 24 ]. Cur-loaded CS-NPs have superior permeation through Strat-M membranes and mouse skin [ 6 ] and significantly accelerate wound healing rates [ 5 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

Terzopoulou

Michopoulou²,

Palamidi

et al. 2020

Polymers

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Patients with psoriasis are dissatisfied with the standard pharmacological treatments, whether systemic or topical, with many of them showing interest in complementary and alternative medicine. Curcumin (Cur), a natural polyphenol derived from turmeric, has recently gained attention for skin-related diseases because of its proven anti-inflammatory action. However, topical treatment with Cur would be inadequate because of its hydrophobicity, instability, and low bioavailability. In addition, hyperkeratosis and lack of moisture in psoriatic skin result in low penetration that would prevent actives from permeating the stratum corneum. In this work, a polymer-based formulation of Cur for the topical treatment of psoriasis is reported. To improve the physicochemical stability of Cur, it was first encapsulated in chitosan nanoparticles. The Cur-loaded nanoparticles were incorporated in a hydrophilic, biocompatible collagen-based patch. The nanoparticle-containing porous collagen patches were then chemically cross-linked. Morphology, chemical interactions, swelling ratio, enzymatic hydrolysis, and Cur release from the patches were evaluated. All patches showed excellent swelling ratio, up to ~1500%, and after cross-linking, the pore size decreased, and their hydrolysis rates decelerated. The in vitro release of Cur was sustained with an initial burst release, reaching 55% after 24 h. Cur within the scaffolds imparted a proliferation inhibitory effect on psoriatic human keratinocytes in vitro.

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Skin-penetrating polymeric nanoparticles incorporated in silk fibroin hydrogel for topical delivery of curcumin to improve its therapeutic effect on psoriasis mouse model

Cited by 111 publications

References 39 publications

Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches

Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches

Fibroin nanoparticles: a promising drug delivery system

Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

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