Skin penetration and fracture strength testing of silicon dioxide microneedles

Khanna, Puneet; Flam, Brenda R.; Osborn, Barbara; Strom, Joel A.; Bhansali, Shekhar

doi:10.1016/j.sna.2010.09.024

Cited by 16 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the hardware was not limited in any way, a safety limit guideline was added to the software; the default value for this limit was set at 150 N, which converts to 1000 kPa when used with the 1.2 cm 2 contact tip. This value is comparable with the limits of other algometers and well below estimates for skin failure limits [10,21,22,33,36].…”

Section: Software: Configuration Of Ascending Load Modesupporting

confidence: 84%

Controlled manual loading of body tissues: towards the next generation of pressure algometer

Evans

Nunzio²

2020

Chiropr Man Therap

View full text Add to dashboard Cite

Assessing the responses of body tissue subjected to mechanical load is a fundamental component of the clinical examination, psychophysical assessments and bioengineering research. The forces applied during such assessments are usually generated manually, via the hands of the tester, and aimed at discreet tissue sites. It is therefore desirable to objectively quantify and optimise the control of manually applied force. However, current laboratory-grade manual devices and commercial software packages, in particular pressure algometer systems, are generally inflexible and expensive. This paper introduces and discusses several principles that should be implemented as design goals within a flexible, generic software application, given currently available force measurement hardware. We also discuss pitfalls that clinicians and researchers might face when using current pressure algometer systems and provide examples of these. Finally, we present our implementation of a pressure algometer system that achieves these goals in an efficient and affordable way for researchers and clinicians. As part of this effort, we will be sharing our configurable software application via a software repository.

show abstract

Section: Software: Configuration Of Ascending Load Modesupporting

confidence: 84%

Controlled manual loading of body tissues: towards the next generation of pressure algometer

Evans

Nunzio²

2020

Chiropr Man Therap

View full text Add to dashboard Cite

show abstract

“…This has allowed a wealth of MN sizes and shapes to be manufactured, which has already been discussed as having an influence on MN insertion. Silicon MNs have significant strength mechanically, and this allows silicon MNs to sufficiently insert into skin [ 151 , 152 ]. Deformation and stress testing of silicon MNs of concave conic shape were undertaken to predict the incidence of MN deformation [ 153 ].…”

Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

View full text Add to dashboard Cite

Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.

show abstract

“…Microneedles are needles similar to the ones useful for hypodermic injections but they present different sizes: from 1-100 microns in length and 1 micron in diameter ( Figure 5). They are manufactured with silicon [44,45], metals such as stainless steel, palladium, nickel and titanium [46][47][48], carbohydrates including galactose, maltose, and polysaccharide [49][50][51], glass [52], ceramics [53], and various other polymers [54,55]. MNs are fabricated in backing that can be applied to the substrate like a patch carrying different drugs by penetrating through the skin, mucosal tissue and sclera [56][57][58][59].…”

Section: Poloxamers For Transdermal Administrationmentioning

confidence: 99%

Poloxamer Hydrogels for Biomedical Applications

2019

View full text Add to dashboard Cite

This review article focuses on thermoresponsive hydrogels consisting of poloxamers which are of high interest for biomedical application especially in drug delivery for ophthalmic, injectable, transdermal, and vaginal administration. These hydrogels remain fluid at room temperature but become more viscous gel once they are exposed to body temperature. In this way, the gelling system remains at the topical level for a long time and the drug release is controlled and prolonged. Poloxamers are synthetic triblock copolymers of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO), also commercially known as Pluronics®, Synperonics® or Lutrol®. The different poloxamers cover a range of liquids, pastes, and solids, with molecular weights and ethylene oxide–propylene oxide weight ratios varying from 1100 to 14,000 and 1:9 to 8:2, respectively. Concentrated aqueous solutions of poloxamers form thermoreversible gels. In recent years this type of gel has arouse interest for tissue engineering. Finally, the use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC). This property is exploited for drug delivery and different therapeutic applications.

show abstract

Skin penetration and fracture strength testing of silicon dioxide microneedles

Cited by 16 publications

References 20 publications

Controlled manual loading of body tissues: towards the next generation of pressure algometer

Controlled manual loading of body tissues: towards the next generation of pressure algometer

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Poloxamer Hydrogels for Biomedical Applications

Contact Info

Product

Resources

About