2009
DOI: 10.1016/j.ijpharm.2008.09.013
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Skin permeation and ex vivo skin metabolism of O-acyl haloperidol ester prodrugs

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Cited by 26 publications
(13 citation statements)
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“…This might be due to the enzymes present in the skin. The extensive hydrolysis of ester pro-drugs during their passage through skin has also been reported by other workers, even when the skin was previously frozen (Morris et al, 2009). The metabolic activity of fresh skin decreases with time.…”
Section: Discussionsupporting
confidence: 72%
“…This might be due to the enzymes present in the skin. The extensive hydrolysis of ester pro-drugs during their passage through skin has also been reported by other workers, even when the skin was previously frozen (Morris et al, 2009). The metabolic activity of fresh skin decreases with time.…”
Section: Discussionsupporting
confidence: 72%
“…Furthermore, the in vivo efficacy study will be conducted in female BALB/c mice, and thus, full-thickness mouse skin was used to ensure consistency between the in vitro-in vivo data set. During the preparation of our homogenate, intracellular enzymes contributing to the breakdown of drugs might have been released, in which case these results represent an overestimation of drug metabolism (58). How these results compare to those with human skin is unclear, but a study comparing paraben breakdown in rat and human skin observed a higher metabolism, on the order of magnitudes, for rat skin, indicating that the level of breakdown in human skin is expected to be lower than the results obtained here (62).…”
Section: Discussionmentioning
confidence: 99%
“…His next major field of research, after contributing to a number of small, unconnected studies on various aspects of percutaneous absorption [107,108,109,110] - which also included an important multicentred study on the validation of laboratory techniques for percutaneous absorption [111] - has been in the area of microneedle-facilitated drug delivery.…”
Section: Keith Brain Reader In Pharmaceutics Welsh School Of Pharmamentioning
confidence: 99%