Skin Prick Test Reactivity to Common Allergens in Finnish Adolescents

Haahtela, Tari; Bjorkstéan, Fred; Heiskala, Marja; Suoniemi, Ilpo

doi:10.1111/j.1398-9995.1980.tb01789.x

Cited by 67 publications

(54 citation statements)

References 13 publications

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“…The prevalences of positive reactions to timothy grass (42%) and common alder pollens (39%) were more common than the reactions to birch pollen (25%). This finding did not change, when the definition of a positive skin test reaction was changed to a mean weal diameter of 3 mm, the cut-off point used in many studies [32][33][34][35]. Such frequent allergy to common alder has not previously been reported in Finland [33,36].…”

Section: Discussionmentioning

confidence: 60%

“…This finding did not change, when the definition of a positive skin test reaction was changed to a mean weal diameter of 3 mm, the cut-off point used in many studies [32][33][34][35]. Such frequent allergy to common alder has not previously been reported in Finland [33,36]. With the cutoff point of 3 mm, the prevalence of positive reactions to all allergens decreased by a mean of 6.6% (range from 2.0% for house dust mite to 14% for birch pollen).…”

Section: Discussionmentioning

confidence: 81%

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Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Timonen¹,

Pekkanen²,

Korppi³

et al. 1995

Eur Respir J

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P Pr re ev va al le en nc ce e a an nd d c ch ha ar ra ac ct te er ri is st ti ic cs s o of f c ch hi il ld dr re en n w wi it th h c ch hr ro on ni ic c r re es sp pi ir ra at to or ry y s sy ym mp pt to om ms s i in n e ea as st te er rn n F Fi in nl la an nd d ABSTRACT: The objective of the present study was to assess the prevalence of asthma and asthma-related symptoms in Finland. We also wondered whether chronic cough may be an indicator of occult asthma. Prevalence and characteristics of children with doctor-diagnosed asthma and chronic respiratory symptoms were investigated in 7-12 year old school children from eastern Finland by using a questionnaire on respiratory symptoms. In addition, skin-prick tests, flow-volume spirometry, and serum total immunoglobulin E (IgE) measurements were performed in children reporting chronic respiratory symptoms.The parent-reported prevalence of doctor-diagnosed asthma was 4.4%, of wheezing 5.4%, of attacks of shortness of breath with wheezing 4.6%, and of dry cough at night 12%. Children with dry cough only (n=195) had less frequent parental asthma, self-reported allergies, daily respiratory medication, and moisture stains or molds at home than asthmatic children (n=180), but these findings were more frequent than among asymptomatic children (n=2,169). The prevalence of at least one positive skin-prick test result was 79% among the asthmatic children and 55% among children with dry cough only. There were no differences between the two symptom groups in serum total IgE levels and spirometric lung functions, except in maximal mid-expiratory flow (MMEF) values, which were significantly lower among children with asthmatic symptoms.The present results support the hypothesis that chronic cough may be an indicator of occult asthma. Therefore, to improve the sensitivity of respiratory questionnaires designed to detect asthma, they should also include questions on chronic cough. In contrast to what has been suggested previously, the prevalence of childhood asthma in eastern Finland was similar to the prevalences reported from other parts of Finland and from other Western European countries.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 81%

Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Timonen¹,

Pekkanen²,

Korppi³

et al. 1995

Eur Respir J

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show abstract

“…[3,[23][24][25][26][27][28][29][30][31] As for cockroach only two European studies described cockroach sensitization in a nonselected pediatric population. A study of German school children aged 5-11 years living in Dresden showed a prevalence of 4.2%; [32] a study of Italian preschool children showed 0.45% sensitization.…”

Section: Discussionmentioning

confidence: 98%

Messages from the Aalst Allergy Study

et al. 2009

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“…The occurrence of dog hypersensitivity, as studied by skin reactivity to dog dander, has been reported at levels varying from 6.6% [1] to 14.6% [2,3] in unse lected populations. The treatment of choice of hyper sensitivity to furred pets is avoidance of contact with them.…”

Section: Introductionmentioning

confidence: 99%

A Sandwich Enzyme Immunoassay for the Detection of Human IgG Antibodies to Dog Allergens

Viander

Nieminen²,

Valovirta

et al. 1987

Int Arch Allergy Immunol

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A double-sandwich enzyme immunoassay (DSEIA) was developed for the detection of human IgG antibodies to dog dander and hair (DH) allergens. Since DH allergens are immunogenic in rabbits, the gamma-globulin fraction of rabbit antiserum to DH (RGG-a-DH; 10 μg/ml) was used for coating of polystyrene microtiter plates. Dog allergens (1 μg/ml of DH extract) were bound to RGG-a-DH. Binding of human IgG Ab to nonimmune RGG (10 μg/ml) – used as a background control – was substracted from the DH specific one and nonspecific binding was further eliminated by using 0.5% of normal rabbit serum in the dilution buffer. Sera were diluted 1:10 in this buffer. Specificity of the assay was shown by absorption experiments: protein A, anti-IgE discs (Phadebas® PRIST) and dog or birch (e5, t3; Phadebas® RAST) allergen discs were used to remove total and allergen specific IgG and IgE, respectively. The results were expressed as net absorbances or as a percentage of a reference serum. A significant correlation (r = 0.65, p <0.01) between IgG (DSEIA) and IgE (RAST) antibodies to dog allergens was observed in 40 untreated dog allergic subjects. The DSEIA was found to be more sensitive than conventional ELISA in detecting IgG Ab in 15 asthmatic children during hyposensitization: a sinificant rise was observed in 14 compared to 12 with ELISA, while no significant increases were observed in the placebo-treated group.

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Skin Prick Test Reactivity to Common Allergens in Finnish Adolescents

Cited by 67 publications

References 13 publications

Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland

Messages from the Aalst Allergy Study

A Sandwich Enzyme Immunoassay for the Detection of Human IgG Antibodies to Dog Allergens

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