Skin-protective properties of peptide extracts produced from white sorghum grain kafirins

Castro-Jácome, Tania P.; Alcántara-Quintana, Luz Eugenia; Montalvo‐González, Efigenia; Chacón-López, Alejandra; Kalixto-Sánchez, Marco A.; Rivera, María del Pilar Silva; López-García, Ulises Miguel; Tovar-Pérez, Erik G.

doi:10.1016/j.indcrop.2021.113551

Cited by 26 publications

(16 citation statements)

References 58 publications

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Section: Resultsmentioning

confidence: 99%

“…Despite this, further investigation is required to confirm these properties in vivo and apply this information to a tissue and organ level like as has been done in an innovative study which determined the protective antiinflammatory effects of Alcalase-derived peptide extracts of white sorghum against the damage induced on human skin by the exposure to ultraviolet-B irradiation (UVB). 164 In addition to the use of Alcalase, the use of trypsin has also resulted in hydrolysates of plant protein from gramineae family (known as grasses) displaying anti-inflammatory abilities by NF-κB signaling pathway regulation. Trypsin hydrolysates from rice and corn silk protein inhibited inflammatory response in vitro and in vivo, respectively.…”

Section: Food and Function Reviewmentioning

confidence: 99%

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Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Food and Function Reviewmentioning

confidence: 99%

Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms

et al. 2022

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“…Papain hydrolyzate from kafirin fraction of white sorghum yielded LRQQ, QLQGV, WQPN, GLQDL, LRQQ, QLQGV, WQPN, AMCGVV, YLRQ, TPCATS, QGVAAA, AQVAQ, and QQLQ with protective effects in HepG2 cells, in addition of radical scavenging and metal chelating abilities [ 107 ]. Interestingly, by using a model of human organotypic skin cultures, fractions lower than 3 and 1 kDa were demonstrated to possess antioxidant, anti-inflammatory, and anti-aging effects against the damage induced by ultraviolet B irradiation [ 105 ].…”

Section: Production Of Bioactive Peptides Derived From Underutilized ...mentioning

confidence: 99%

Exploration of the Nutritional and Functional Properties of Underutilized Grains as an Alternative Source for the Research of Food-Derived Bioactive Peptides

2023

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The estimated increase in world population will lead to a deterioration in global food security, aggravated in developing countries by hidden hunger resulting from protein deficiency. To reduce or avoid this crisis, a dietary shift towards the consumption of sustainable, nutrient-rich, and calorically efficient food products has been recommended by the FAO and WHO. Plant proteins derived from grains and seeds provide nutritionally balanced diets, improve health status, reduce poverty, enhance food security, and contain several functional compounds. In this review, the current evidence on the nutritional and functional properties of underutilized grains is summarized, focusing on their incorporation into functional foods and the role of their proteins as novel source of bioactive peptides with health benefits.

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“…With the emergence of an aging population and the gradual deepening of health consciousness in the minds of the current society, skin aging has attracted much attention ( 1 ). Skin aging manifests as wrinkles, loose skin, and decreased elasticity.…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment of Cucurbita moschata seed polypeptides toward the protection of human skin cells against oxidative stress-induced aging

Liu

Wang²,

Yang³

et al. 2023

Front. Nutr.

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Skin aging has attracted much attention among the current aging population of society. The seeds of Cucurbita moschata possess a variety of potential biological activities as a healthy diet. However, limited information is available on the skin-antiaging properties of C. moschata seed protein and its hydrolysate. Herein, we developed a novel strategy for protecting human skin cells against oxidative stress-induced aging by C. moschata seed polypeptides. C. moschata seed polypeptides (CSPs) with different molecular weight distributions were successfully prepared by controlling the protease hydrolysis time. The proportions of < 1,000 Da polypeptides of P-1, P-2, and P-3 were 0.11, 20.26, and 92.72%, respectively. P-3 contained the highest proportion of polypeptides of size < 1,000 Da, which was observed to promote human skin fibroblast (HSF) growth by MTT assay, cell cycle, and morphology. P-3 has an efficient repair effect on the H2O2-induced aging of HSF cells. To explain this phenomenon, cell lifespan, intracellular ROS level, superoxide dismutase (SOD) activity, and glutathione (GSH) content were investigated to reveal the interactions between P-3 and antiaging. With the increase in P-3 concentration, the ROS level significantly decreased, and the SOD activity and GSH content significantly increased in H2O2-induced HSF cells. These findings indicated that CSPs have the potential to inhibit skin aging, which could be advantageous in the health industry for providing personal care.

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Skin-protective properties of peptide extracts produced from white sorghum grain kafirins

Cited by 26 publications

References 58 publications

Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms

Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms

Exploration of the Nutritional and Functional Properties of Underutilized Grains as an Alternative Source for the Research of Food-Derived Bioactive Peptides

Comparative assessment of Cucurbita moschata seed polypeptides toward the protection of human skin cells against oxidative stress-induced aging

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