Skin Rash and Fever of Unknown Origin - A Diagnostic Challenge

Moreira, Albina; Silva, Miguel Borges; Afonso, Ana; Rodrigues, Cecília M. P.

doi:10.12890/2019_001023

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…[ 15 ] The occurrence of generalized rashes is the most frequent condition seen by primary care physicians, which sometimes becomes a diagnostic challenge. [ 16 ] In our study leading number of cases were enrolled for febrile illness with any type of rash, which contributed to 32.24% of total cases. The differential diagnosis for febrile patients with a rash is extensive.…”

Section: Discussionmentioning

confidence: 99%

A spectrum of viral diseases in Odisha state, eastern India: An evidence-based analysis from 2010–2017

Sabat¹,

Subhadra²,

Ho³

et al. 2022

Journal of Postgraduate Medicine

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Introduction: Emerging and re-emerging viral diseases are a major threat to public health. Odisha, being one of the coastal states in the country, reports many viral illnesses due to its typical geographical location. This study focuses on the prevalence of different viral diseases in the state of Odisha, India, from 2010–2017. Material and Methods: A total of 43,397 patients with clinical suspicion of viral diseases were screened for different viral etiologies during 2010–2017. The laboratory diagnosis was conducted by serology (ELISA) and RT-PCR for 24 different viruses, i.e., dengue, chikungunya, Japanese encephalitis, hepatitis A virus, hepatitis E virus, hepatitis B virus, hepatitis C virus, rotavirus, herpes simplex virus-1 and herpes simplex virus-2, Epstein-Barr virus, cytomegalovirus, and respiratory viruses. Patients were enrolled from sporadic hospital admissions and outbreaks under different categories as per clinical diagnoses like fever with rash, diarrhoea, encephalitis, jaundice, respiratory illness, and fever of unknown etiology. Results: The majority of patients belonged to exanthematous group, i.e., fever with rash (32.24%). The number of males was more in all categories except fever with rash, where females (53.34%) were more. Children <16 years of age were found to be the predominant age group for suspected viral diarrhoea (85.26%), encephalitis (76.96%), fever of unknown origin (40.16%), and respiratory infections (27.23%). Conclusion: Not only vector-borne diseases pose a threat to the Odisha state, but other viral illnesses have also emerged. This detailed report of different viral diseases in the state of Odisha will support public health management.

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Section: Discussionmentioning

confidence: 99%

A spectrum of viral diseases in Odisha state, eastern India: An evidence-based analysis from 2010–2017

Sabat¹,

Subhadra²,

Ho³

et al. 2022

Journal of Postgraduate Medicine

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“…Adult-onset Still's disease is one condition that can also present with skin rash and PUO, however the rash is usually macular or maculopapaular and not folliculitis type. In addition, this condition is usually associated with musculoskeletal symptoms in the form of arthralgia and/or arthritis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Pyrexia of Unknown Origin

Soliman¹,

Shirazi-Nejad²,

Bullas³

et al. 2021

Cureus

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A previously fit and well 29-year-old man with no significant recent travel or contact history presented to the hospital with 11 days of feeling unwell, intermittent diarrhea, abdominal pain and a skin rash that was consistent with folliculitis. Despite resolution of these index symptoms he continued with recurring fever of 38.5 degrees centigrade and weight loss of six Kilograms over the next three weeks. Extensive investigations to find a cause for the unexplained persistent fever failed to reveal an etiology, hence fulfilling pyrexia of unknown origin definition (PUO). None of the three main causes of PUO, namely infections, autoimmune diseases or underlying malignancy, were confidently found. Colonoscopy was suggested following a review of the abdominal CT scan to investigate possible thickening of the bowel wall. A diagnosis of atypically presenting Crohn's disease was eventually made and confirmed by colonoscopy and histology. The fever responded promptly to treatment of the Crohn's disease and he remained well at follow-up at six and 12 months after the initial presentation. In conclusion, it is important to keep in mind that PUO can be a rare initial presentation of inflammatory bowel disease in young adults with little or no gastrointestinal symptoms.

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Skin Rash and Fever of Unknown Origin - A Diagnostic Challenge

Cited by 2 publications

References 2 publications

A spectrum of viral diseases in Odisha state, eastern India: An evidence-based analysis from 2010–2017

A spectrum of viral diseases in Odisha state, eastern India: An evidence-based analysis from 2010–2017

An Unusual Case of Pyrexia of Unknown Origin

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