Skin rash by gefitinib is a sign of favorable outcomes for patients of advanced lung adenocarcinoma in Japanese patients

Sugiura, Yasoo; Nemoto, Etsuo; Kawai, Osamu; Ohkubo, Yasuyuki; Fusegawa, Hisae; Kaseda, Shizuka

doi:10.1186/2193-1801-2-22

Cited by 10 publications

(10 citation statements)

References 28 publications

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“…The occurrence of skin rash is a predictor of gefitinib efficacy in patients with advanced NSCLC, as confirmed in numerous studies . Although this may be immune mediated, a PK relationship is still likely based on biology similar to that of other TKIs.…”

Section: Pharmacokinetic Properties Of Specific Oral Agents That Are mentioning

confidence: 84%

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Pharmacokinetic‐Guided Dosing of New Oral Cancer Agents

Lucas

Martin

2017

The Journal of Clinical Pharma

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Generally, licensed drug-dosing recommendations for chemotherapy are based on results from clinical trials in which subjects are usually of relatively normal body size, middle-aged, and are relatively racially homogeneous, with minimal comorbidity and specific tumor characteristics. Very few nontrial patients meet these characteristics, resulting in clinical practice having to extrapolate dosing recommendations to the specific patient. There is insufficient research on the impact of obesity-associated physiological changes prevalent in patients with common cancers on standard pharmacokinetic and pharmacodynamic parameters. Yet quantifying the influence of obesity on the pharmacology of chemotherapy is vital, as dosing inappropriate for body composition (ie, flat dosing or mg/kg based on total body weight) may increase the risk of adverse events and reduce clinical effectiveness. Unfortunately, there are few cancer guidelines to aid clinicians in selecting the optimal dose in the obese-even recent guidelines are based predominantly on clinical opinion/current practice in treating obese patients, rather than evidence. Data in many other vulnerable groups, for example, those with significant comorbidity and older patients, are also scarce. Because of the known limitations of body surface area-guided dosing, therapeutic drug monitoring or pharmacokinetic-guided dosing, which predicts an individual's exposure, has increasingly been shown to be a powerful tool in cancer therapy. Used appropriately, it can adjust for differences in pharmacokinetic parameters not considered when body size-based dosing or "one dose fits all" is used. This review will focus predominantly on the rationale for pharmacokinetic-guided dosing of the newer oral molecularly targeted antineoplastics in people whose drug exposure is not predicted by their physiology or body composition.

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Section: Pharmacokinetic Properties Of Specific Oral Agents That Are mentioning

confidence: 84%

“…89,[100][101][102][103] Although this may be immune mediated, a PK relationship is still likely based on biology similar to that of other TKIs.…”

Section: Additional Tkis Potentially Feasible For Tdmmentioning

confidence: 99%

Pharmacokinetic‐Guided Dosing of New Oral Cancer Agents

Lucas

Martin

2017

The Journal of Clinical Pharma

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“…Therefore, we replaced these missing values by single imputation using the Expectation Maximization algorithm. This is an efficient way of handling missing data when it is missing at random or completely at random (Dong and Peng 2013).…”

Section: Discussionmentioning

confidence: 99%

Loosening the Reins or Tightening Them? Complex Relationships Between Parenting, Effortful Control, and Adolescent Psychopathology

Houtepen

Sijtsema

Klimstra

et al. 2018

Child Youth Care Forum

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Background Adolescents face major developmental tasks such as increasing individuation and establishing autonomy. These developmental tasks increase demands on adolescent self-control, hereby putting youth with poor effortful control at risk for psychopathology. Specific parenting behaviors might be warranted to buffer against this risk. Objective This study was designed to examine parenting-related risk and protective factors in the associations between effortful control and adolescent psychopathology. We hypothesized that youth with poor effortful control require more parental involvement (i.e., lower autonomy granting) to help complete these developmental tasks and subsequently avoid psychopathology. Methods Via adolescent self-reports (N = 809), associations between effortful control, perceived parenting (i.e., psychological control and autonomy support), and externalizing (i.e., interpersonal aggression and rule-breaking) and internalizing problems (i.e., depressive and anxiety problems) were examined. Results Regression analyses supported our hypothesis in boys: higher levels of autonomy support exacerbated the negative association between effortful control and rule-breaking. In contrast, in girls this was the case for lower levels of autonomy support. For both genders, low autonomy support and psychological control exacerbated negative associations between effortful control and internalizing problems. No buffering effects of parenting were found. Conclusions Low effortful control is associated with psychopathology in adolescents, but parenting can affect this association in several ways, depending on the type of psychopathology and the adolescent's gender. Future research should focus on finding 'optimal' levels of parental control that can help avoid psychopathological problems in youth with poor effortful control.

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“…Because the maximum amount of missing data for any given variable in our sample less than 7%, shown in Table 2, we judged 10 imputation sets more than sufficient for convergence. Further evidence of convergence can be determined by examining the worst linear function (WLF), a constructed statistic that converges more slowly than all other parameters in the model (Dong & Peng, 2013). Figure 1 shows no trend in the WLF, indicating that all the parameters have converged in the model.…”

Section: Covariatesmentioning

confidence: 99%

Institutional and Ethnic Variations in Postgraduate Enrollment and Completion

Tienda

Zhao

2017

The Journal of Higher Education

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Using the B&B:93/03 longitudinal cohort survey, we investigate (1) whether and how much variations in the timing of enrollment, the type of undergraduate institution attended, and type of graduate program pursued contribute to observed racial and ethnic differentials in post-baccalaureate enrollment, and (2) whether the observed enrollment differentials carry over to degree attainment. Dynamic event history methods that account both for the timing of matriculation and the hazard of enrolling reveal that compared to whites underrepresented minorities enroll earlier and also are more likely to enroll in doctoral and advanced professional degree programs relative to nonenrollment. Our results reveal sizable differences in the cumulative probability of advanced degree attainment according to undergraduate institutional mission, with graduates from research institutions enjoying a decided advantage over liberal arts college graduates. The conclusion discusses limitations of the analysis, directions for further research, and implications for strengthening the minority pipeline to graduate school.

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Skin rash by gefitinib is a sign of favorable outcomes for patients of advanced lung adenocarcinoma in Japanese patients

Cited by 10 publications

References 28 publications

Pharmacokinetic‐Guided Dosing of New Oral Cancer Agents

Pharmacokinetic‐Guided Dosing of New Oral Cancer Agents

Loosening the Reins or Tightening Them? Complex Relationships Between Parenting, Effortful Control, and Adolescent Psychopathology

Institutional and Ethnic Variations in Postgraduate Enrollment and Completion

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