Skin Replacement in Dupuytren’s Disease

Hall, Per; Fitzgerald, Annelies; Sterne, G.D.; Logan, A. M.

doi:10.1016/s0266-7681(97)80061-7

Cited by 71 publications

(54 citation statements)

References 10 publications

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“…Clinically, full-thickness skin grafts (in which the dermis is included) have been shown to attenuate recurrence of DD in some studies [7,[74][75][76], implying that local environment of the DD cord left behind after resection may contain factors that promote disease recurrence. Our in vitro data suggest that PF fibroblasts, derived from the palmar fascia immediately adjacent to DD cord, are sensitive to periostin-induced proliferation.…”

Section: Discussionmentioning

confidence: 99%

Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells

Vi¹,

Feng²,

Zhu³

et al. 2009

Experimental Cell Research

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Dupuytren's disease, (DD), is a fibroproliferative condition of the palmar fascia in the hand, typically resulting in permanent contracture of one or more fingers. This fibromatosis is similar to scarring and other fibroses in displaying excess collagen secretion and contractile myofibroblast differentiation. In this report we expand on previous data demonstrating that POSTN mRNA, which encodes the extra-cellular matrix protein periostin, is up-regulated in Dupuytren's disease cord tissue relative to phenotypically normal palmar fascia. We demonstrate that the protein product of POSTN, periostin, is abundant in Dupuytren's disease cord tissue while little or no periostin immunoreactivity is evident in patient-matched control tissues. The relevance of periostin up-regulation in DD was assessed in primary cultures of cells derived from diseased and phenotypically unaffected palmar fascia from the same patients. These cells were grown in type-1 collagen-enriched culture conditions with or without periostin addition to more closely replicate the in vivo environment. Periostinwas found to differentially regulate the apoptosis, proliferation, α smooth muscle actin expression and stressed Fibroblast Populated Collagen Lattice contraction of these cell types. We hypothesize that periostin, secreted by disease cord myofibroblasts into the extra-cellular matrix, promotes the transition of resident fibroblasts in the palmar fascia toward a myofibroblast phenotype, thereby promoting disease progression.

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Section: Discussionmentioning

confidence: 99%

Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells

Vi¹,

Feng²,

Zhu³

et al. 2009

Experimental Cell Research

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“…This is consistent with the literature, which suggests that recurrence of Dupuytren disease occurs less frequently in patients who have had a dermofasciectomy. 12, 13 Tonkin et al 14 compared outcomes in 100 patients treated by dermofasciectomy and fasciectomy and found that the rate of disease recurrence in the former group was dramatically reduced. Tonkin et al 9 also reported that amputation specimens following dermofasciectomy showed no histologic recurrence of the disease under the skin graft.…”

Section: N Dermofasciectomymentioning

confidence: 99%

A Review of Common Practice in Dupuytren Surgery

Au-Yong

Wildin

Dias

et al. 2005

Techniques in Hand &Amp; Upper Extremity Surgery

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Aspects of decision making, postoperative management, and complications routinely discussed with patients were investigated using a questionnaire completed by 141 hand surgeons of various grades who regularly manage Dupuytren disease. This account presents the results of this questionnaire study, and the literature is discussed in context. A brief description of operative technique in fasciectomy and dermofasciectomy is included. Thresholds for surgery did not differ greatly among the surgeons who completed the questionnaire. The training background and the number of operations performed by surgeons also did not generally influence surgical decision making. Postoperative care regimens were very similar. However, there was great variation in the complications routinely included in discussions with patients undergoing surgery for Dupuytren contracture. Recurrence and nerve damage were the only 2 mentioned by almost all surgeons. There was also diversity in what rates were quoted for complications, particularly recurrence (median 33%, range 0%-100%) and stiffness (median 10%, range 0%-100%).

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“…L'excision de la peau avec la lésion et son remplacement par une greffe cutanée ou partiellement par un lambeau local (latérodigital, intermétacarpien palmaire) semble être seule capable d' éviter ou de diminuer les récidives [10], valant parfois le qualificatif de « pare-feu » à la greffe. Plusieurs études ont montré la réduction [11][12][13], voire l'absence [1,[14][15][16][17][18] de récidive avec dermofasciectomie et greffe de peau. Ces auteurs recommandent d'ailleurs d'utiliser cette technique d'emblée dans les formes agressives [11][12][13] ou secondairement dans les formes récidivantes [12,15,[17][18][19].…”

Section: Discussionunclassified