Skin-Sensitizing Antibodies in Schistosoma mansoni Infected Baboons: Evidence for the Presence of Two Types

Greene, Nathan D.; Damian, Raymond T.

doi:10.3181/00379727-141-36761

Cited by 5 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A logical place for parasite attrition may be schistosomules in the skin (6). Repeated infection of baboons with S. mansoni has been shown to result in development of immediate hypersensitivity reactions after skin injection of SWAP and elevated levels of parasite-specific IgE (11,17,18). The cercarial penetration described in these earlier studies showed immediate hypersensitivity reactions to penetrating cercariae similar to those observed in repeatedly infected baboons in the present study.…”

Section: Fig 3 Recombinant Human Il-12 Stimulates Proliferation Of supporting

confidence: 76%

“…They become infected with human schistosomes both experimentally and in the wild (9,10,15,32,41,42). They develop partial protection with natural infection (10,41), form pathologies that closely resemble human infection (44), and acquire immediate hypersensitivity responses to schistosome antigens (11,17,18,25). However, studies of immune responses in nonhuman primates have been limited.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Role of Adult Worm Antigen-Specific Immunoglobulin E in Acquired Immunity toSchistosoma mansoniInfection in Baboons

et al. 1999

View full text Add to dashboard Cite

Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined the immune correlates of protection in baboons (Papio cynocephalus anubis), which are natural hosts forSchistosoma mansoni and also develop allergic-type immunity with infection. In one experiment, animals were exposed to a single infection (1,000 cercariae) or were exposed multiple times (100 cercariae per week for 10 weeks) and subsequently were cured with praziquantel prior to challenge with 1,000 cercariae. Singly and multiply infected animals mounted 59 and 80% reductions in worm burden, respectively (P < 0.01). In a second experiment, animals were inoculated with S. mansoniova and recombinant human interleukin 12 (IL-12). This produced a 37 to 39% reduction in adult worm burden after challenge (P< 0.05). Parasite-specific IgG, IgE, IgM, and peripheral blood cytokine production were evaluated. The only immune correlate of protection in both experiments was levels of soluble adult worm antigen (SWAP)-specific IgE in serum at the time of challenge infection and/or 6 weeks later. Baboons repeatedly infected with cercariae or immunized with ova and IL-12 developed two- to sixfold-greater levels of SWAP-specific IgE in serum than did controls, and this correlated with reductions in worm burden (r 2, −0.40 to −0.64; P, <0.01). Thus, in baboons and unlike mice, adult worm-specific IgE is uniquely associated with acquired immunity to S. mansoni infection. This similar association of parasite-specific IgE and protection among primates infected with schistosomiasis, along with similar pathology, anatomy, and genetic make-up, indicates that baboons provide an excellent permissive experimental model for better understanding the mechanisms of innate and acquired immunity to schistosomiasis in humans.

show abstract

Section: Fig 3 Recombinant Human Il-12 Stimulates Proliferation Of supporting

confidence: 76%

mentioning

confidence: 99%

Role of Adult Worm Antigen-Specific Immunoglobulin E in Acquired Immunity toSchistosoma mansoniInfection in Baboons

et al. 1999

View full text Add to dashboard Cite

show abstract

Protein quality of raw and autoclaved cowpeas: Comparison between some insect resistant and susceptible varieties

Umoren

Tewe

Bokanga

et al. 1997

Plant Food Hum Nutr

View full text Add to dashboard Cite

A comparative study was conducted with four improved cowpea (2 pod bug resistant and 2 susceptible) varieties to assess the effect of autoclaving at 105 degrees C under 15 psi for 30 min on their protein quality, as measured by the levels of some antinutritional factors and performance of rats fed the different cowpea diets. Also, the relationships between antinutrients in the cowpeas and protein quality indicators were examined. Results showed that autoclaving completely eliminated trypsin inhibitor, hemagglutinin and HCN, whereas it reduced significantly (p < 0.01) the levels of phytic and tannic acids in the cowpeas. In both raw and autoclaved forms, the insect susceptible cowpeas were better (p < 0.05) utilized than their resistant counterparts, a condition which was attributable to lower levels of antinutrients in the susceptible varieties. In the raw cowpeas, trypsin inhibitor, hemagglutinin and HCN were significant variables affecting cowpea protein utilization, while in autoclaved samples, tannic and phytic acids were important though nonsignificant (p > 0.05) factors. It was concluded that autoclaving at the above temperature and time improved the protein quality of the insect susceptible more than the insect resistant cowpea varieties.

show abstract

The nutritional significance of plant protease inhibitors

1979

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Skin-Sensitizing Antibodies in Schistosoma mansoni Infected Baboons: Evidence for the Presence of Two Types

Cited by 5 publications

References 10 publications

Role of Adult Worm Antigen-Specific Immunoglobulin E in Acquired Immunity toSchistosoma mansoniInfection in Baboons

Role of Adult Worm Antigen-Specific Immunoglobulin E in Acquired Immunity toSchistosoma mansoniInfection in Baboons

Protein quality of raw and autoclaved cowpeas: Comparison between some insect resistant and susceptible varieties

The nutritional significance of plant protease inhibitors

Contact Info

Product

Resources

About