Skin Signs of Other Systemic Diseases

Paller, Amy S.; Mancini, Anthony J.

doi:10.1016/b978-0-323-24475-6.00025-x

Hurwitz Clinical Pediatric Dermatology 2016

DOI: 10.1016/b978-0-323-24475-6.00025-x

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Skin Signs of Other Systemic Diseases

Amy S. Paller

Anthony J. Mancini

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Cited by 2 publications

References 362 publications

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Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. SPD is similar to two other disease entities. Both SPD-type immunoglobulin (Ig)-A pemphigus and annular pustular psoriasis clinically and histologically present similarly to SPD. Immunologic studies separate SPD-type IgA pemphigus from SPD and pustular psoriasis. However, there is still an unclear designation as to whether SPD is its own entity distinct from pustular psoriasis, as the once thought characteristic histologic picture of psoriasis does not hold true for pustular psoriasis. SPD has been reported to occur in association with several neoplastic, immunologic, and inflammatory conditions. Dapsone remains the first-line treatment for SPD, although dapsone-resistant cases have been increasingly reported. Other therapies have been used singly or as adjunctive therapy with success, such as corticosteroids, immunosuppressive agents, tumor necrosis factor inhibitors, and ultraviolet light therapy. This article provides a review of the last 30 years of available literature, with a focus on successful treatment options and a suggestion for reappraisal of the classification of SPD.

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Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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Knuckle lesions in inherited and acquired disorders

Adya

Inamadar

Palit

et al. 2021

Indian Dermatology Online Journal

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Skin lesions occurring over the knuckles can be a primary or characteristic manifestation of a disorder. Characteristic knuckle lesions may also be important cutaneous features of various internal disorders when they serve as useful clinical pointers, as well as may speak of the disease severity in certain instances. Furthermore, knuckle lesions also speak of various external factors as the underlying cause of the disease/lesions, such as trauma – occupational or otherwise, and contact dermatitis. Although knuckles essentially imply dorsal aspect of the metacarpophalangeal joints, many of the lesions described as those 'involving the knuckles' are seen over the proximal and/or less frequently, the distal interphalangel joints as well. This review presents a compilation of various inherited and acquired dermatoses and dermatological manifestations of various internal disorders associated with different forms of knuckle lesions.

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Skin Signs of Other Systemic Diseases

Cited by 2 publications

References 362 publications

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

Knuckle lesions in inherited and acquired disorders

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